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Non infectious diseases - class-VIII

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What are symptoms of carbon monoxide exposure?

  1. Loss?of consciousness

  2. Memory problems

  3. Vomiting

  4. Both a and b


Correct Option: D

Mark the correct statement (w.rt. sickle cell-anaemia) - 

  1. Homozygous individuals for $Hb^s$ are apparently unaffected

  2. Heterozygous individuals exhibit sickle-cell trait

  3. Heterozygous individuals are affected as well as carrier

  4. Homozygous individuals for $Hb^A$ show the diseased phenotype


Correct Option: A

The most basic amino acid is

  1. Arginine

  2. Hisstidine

  3. Glycine

  4. Glutamine


Correct Option: A
Explanation:

Glutamine and Glycine are not basic amino acids. Only Arginine and Histidine are basic amino acids. Histidine is weakly charged under physiological ph. Hence, Arginine is the most basic amino acid. 

So the correct option is 'Arginine'.

The carcinogenic ingredient of tobacco smoke is

  1. Nicotine

  2. Polycyclic aromatic hydrocarbon

  3. Carbon monoxide

  4. Tar


Correct Option: B
Explanation:

Polycyclic aromatic hydrocarbons are a group of chemicals that are formed during the incomplete burning of coal, oil, gas, wood, garbage or other organic substances, such as tobacco and charbroiled meat.
They are the carcinogenic or cancer-causing substance in the tobacco smoke.
Therefore, the correct answer is option B.

Which one of the following is the correct statement regarding the particular psychotropic drug specified?

  1. Cocaine causes after thought perceptions and hallucinations.

  2. Opium stimulates nervous system and causes hallucinations.

  3. Morphine leads to delusions and disturbed emotions.

  4. Barbiturates cause relaxation and temporary euphoria.


Correct Option: D
Explanation:

Cocaine are stimulants that is they elevate mood, increase feelings of well-being and increase energy and alertness.
Opium  and morphine are powerful pain-killers. They produce a quick, intense feeling of pleasure followed by a sense of well-being and calm.
Barbiturates are depressants that slow down the normal brain function.
Thus, the correct answer is 'Barbiturates cause relaxation and temporary euphoria'.

Smoking can result in 

  1. Fever

  2. Death

  3. Head ache

  4. All of the above


Correct Option: B
Explanation:

Smoking is associated with significant morbidity and mortality. Smoking still remains one of the leading causes of preventable death. Smoking has the dubious distinction of affecting all the systems from head to foot. Cigarette smoking causes many types of cancer. It also increases the risk of cardiovascular diseases. Exposure to tobacco smoke during pregnancy can lead to delivery complications and increase the risk of health problems in the newborn. Quitting smoking significantly reduces the health risks caused by exposure to tobacco smoke. 

So, the correct answer is 'Death'.

Which one of the following has a long term effect on the health of an individual?

  1. Common cold

  2. Chicken pox

  3. Chewing tobacco

  4. Stress


Correct Option: C
Explanation:

Tobacco (Nicotiana tabacum) belongs to family Solanaceae, is a silent long term killer can be consumed in a variety of ways like smoking, chewing, sniffing etc. Nicotine is a highly poisonous substance found in tobacco that increases pulse rate and blood pressure. It also increases stomach acidity, which is accompanied by a lack of appetite. Over time, tobacco users can look forward to such serious risks as narrowing or hardening of the arteries, respiratory infections, emphysema, stomach ulcers, chronic cough, and cancer of the mouth, throat, and lungs.

Emphysema is a condition resulting from

  1. cigarette smoking

  2. liquor consumption

  3. drug addiction

  4. reduced oxygen carrying capacity of blood.


Correct Option: A
Explanation:

Emphysema is a respiratory disorder which occurs due to the inflation or abnormal distension of the bronchioles or alveolar sacs resulting in the loss of their elasticity. Cigarette smoking and chronic bronchitis are the causes of this disease.

What part of hemoglobin is affected in sickle cell anaemia?

  1. $\alpha$-polypeptide chains

  2. $\beta$-polypeptide chains

  3. Both $\alpha$- and $\beta$- polypeptide chains

  4. None of these


Correct Option: B
Explanation:

Hemoglobin has four chains: two alpha chains and two beta chains with heme and iron part along with oxygen. There are some hydrophobic substances (water-hating) present on the surface of proteins. These hydrophobic residues forms cluster and pocket-like structure on the surface of beta chains. These pockets are responsible for diseases like sickle cell anemia also in the beta chain the position of glutamic acid at sixth place in the chain is replaced by valine leading to the shape of red blood cells to be sickle-like due to loss of oxygen.

So, the correct option is 'Beta-polypeptide chains'.

Incidence of Emphysema - a respiratory disorder is high in cigarette smokers. In such cases

  1. the bronchioles are found damaged

  2. the alveolar walls are found damaged

  3. the plasma membrane Is found damaged

  4. the respiratory muscles are found damaged.


Correct Option: B
Explanation:

Emphysema is. a condition of short breath due to breakdown of alveolar wall and'reduction of respiratory area due to smoking.

Cells obtained from cancerous tumours are known as

  1. Hybridoma

  2. Lymphocyte

  3. Monoclonal cells

  4. Myeloma


Correct Option: D
Explanation:
  • Myeloma, also known as multiple myeloma, is a blood cancer arising from plasma cells. 
  • Plasma cells are a type of white blood cell made in the bone marrow. Bone marrow is the ‘spongy’ material found in the centre of the larger bones in the body and is where all blood cells are made. 
  • Myeloma develops when DNA is damaged during the development of a plasma cell. 
  • This abnormal cell then starts to multiply and spread within the bone marrow.
  • Hence, Cells obtained from cancerous tumours are known as Myeloma.
  •  So, the correct answer is 'myeloma'.

Which one of the following in not a feature of cancerous cells?

  1. They divide in an uncontrolled manner.

  2. They do not remain confined to one localized area.

  3. They compete with normal cells for vital nutrients.

  4. They show contact inhibition.


Correct Option: D
Explanation:

Cancer is a group of disease, that involves abnormal cell growth (abnormal cell division), with the potential to invade or spread to other parts of the body. They compete with normal cells for nutrients. Contact inhibition is a growth mechanism, which functions to keep cells growing into a layer one cell thick or monolayer. The cancer cells do not show contact inhibition and they grow uncontrollably.
Thus, the correct answer is option (D), 'They show contact inhibition'.

What causes PCBs and dioxins?

  1. Heart disease

  2. Cancer

  3. Lung disease

  4. Skin infection


Correct Option: B

HeLa cells used in cell biology are

  1. Cancerous cells grown in cancer research laboratory

  2. Cervial cancer cell derivatives

  3. Both A and B 

  4. None of the above


Correct Option: C
Explanation:

  • HeLa cells are the cell type in immortal cell lines used in scientific research. It is the oldest and most commonly used human cell line.
  • The line was derived from cervical cancer cells taken on February 8, 1951, from Henrietta Lacks, a patient who died of her cancer on October 4, 1951.  These cells are grown in a laboratory and are used for conducting many experiments.
Thus, the correct answer is option C.

Cancer cells are characterized by

  1. Uncontrolled growth

  2. Invasion of local tissue

  3. Spreading to other body parts

  4. All of the above


Correct Option: D
Explanation:

Cancer is a group of diseases involving the abnormal cell growth where there is invasion of the local tissue and there is a potential to invade or spread to other body parts .
Therefore, the correct answer is option D.

Which one of the following is not a property of cancerous cells?

  1. They compete with normal cells for vital nutrients.

  2. They do not remain confined in the area of formation.

  3. They divide in an uncontrolled manner.

  4. They show contact inhibition.


Correct Option: D
Explanation:

During tumorigenesis, cancerous cells undergo rapid cell division and compete with normal cells for nutrients.
Cancer cells spread to other parts of the body, a process called metastastize i.e., are not confined in area  of formation.
Cancer is the result of cells that uncontrollably grow and do not die.
So, statements A, B and C are correct.
Normal cells when grown in culture, will become growth inhibited, when they encounter another cell. This is contact inhibition and Cancer cells show no contact inhibition as they do not stop dividing and keep growing.
Thus, the correct answer is option (D), 'They show contact inhibition'.

................. is the process by which cancer cells spread from one region of the body to other 

  1. Hypostasis

  2. Metastasis

  3. Parastasis

  4. Parasitosis


Correct Option: B
Explanation:

Metastasis is the movement of spreading of cancer cells from one organ or tissue to another. Cancer cells usually spread through the blood or the lymph system. It is mainly caused due to the mutagens which cause a sudden heritable change in the DNA content which leads to fatal abnormalities.
So, the correct answer is option B.

Alteration in which genes leads to cancer

  1. Proto-oncogenes

  2. Tumor suppressor gene

  3. Tumor virus gene

  4. All of the above


Correct Option: D
Explanation:

Genes are found in the DNA of every cell of the human body. The functions of the cell, its growth pattern, divisions and life are all determined and control by the genes. Cancers in the human body are the result of mutations or changes in one or more genes in a cell leading to an abnormal protein or no protein at all. An abnormal protein in the cells causes them  to multiply uncontrollably and become cancerous. Any alteration in the tumour suppressor gene may result in cancer. 

The region of the viral genome (DNA in DNA tumour viruses or RNA in RNA-tumour viruses) that can cause a tumour is called an oncogene. These mutations are generally acquired mutations. However, alterations or mutations of cell proliferation genes or oncogenes lead to cancer.
So, the correct answer is option D. 

Cancer cells are characterised by 

  1. Uncontrolled growth

  2. Spreading to the other body part

  3. Invasion of local tissue

  4. All of the above


Correct Option: D
Explanation:

Cancer cells are cells that divide rapidly, forming solid tumours or flooding the blood with abnormal cells. Malignant cancerous cells spread from their initial site to other organs or tissues resulting in metastasis. Cancer cells undergo invasion of local tissue i.e., direct extension and penetration by cancer cells into neighbouring tissues. Hence, cancer cells are characterised by uncontrolled growth, spreading to other body part and invasion of local tissue.

So, the correct answer is 'All of the above'.

Transformation of a normal cell to cancer cell may start with changes in 

  1. Cytoplasm

  2. Nucleus

  3. Mitochondria

  4. Fibronetin


Correct Option: B
Explanation:
  • A gene is the basic physical and functional unit of heredity. Genes are made up of DNA and DNA is present inside the nucleus.
  • Mutations in genes can cause cancer by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death. As a mass of cancerous cells grows, it can develop into a tumour.
  • Hence Transformation of a normal cell to cancer cell may start with changes in  Nucleus.
  • So, the correct answer is 'Nucleus'.

Which of the following statements is not true for cancer cells in relation to mutations?

  1. Mjutations in proto-oncogenes accelerate the cell cycle

  2. Metations destroy telomerase inhibitor

  3. Mutations inactive the cell control

  4. Mutations inhibit prdduction of telomerase


Correct Option: A

Which one is not property of cancer cells 

  1. They show contact inhibition

  2. Divide in uncontrolled manner

  3. Compete with normal cells for vital nutrients

  4. Do not remain confined to area of formation


Correct Option: A
Explanation:
  • Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. 
  • All cancer cells show the five properties. They are: 
  1. Continuous growth and division. 
  2. Avoidance of programmed cell death. 
  3. Competes with normal cells for vital nutrients.
  4.  Promoting blood vessel construction. 
  5. Invasion of tissue and formation of metastases. Hence, the property which cancer cells does not have is they show contact inhibition.
 So, the correct answer is 'They show contact inhibition'.

Which one of the following techniques is safest for the detection of cancers?

  1. Radiography (X-ray)

  2. Computed tomography (CT)

  3. Histopathological studies

  4. Magnetic resonance imaging (MRI)


Correct Option: A

Proliferation of cancer cells is not limited because of:

  1. Differing surface proteins

  2. Differing cholesterol level

  3. Aberrant chromosomal complement

  4. Both A and C


Correct Option: D
Explanation:

The difference between normal tissues and cancer tissues is the rate of metabolism.  In normal cells, hundreds of genes intricately control the process of cell division. Normal growth requires a balance between the activity of those genes that promote cell proliferation and those that suppress it. However, in the case of cancer cells, they involve abnormal growth. Cells become cancerous after mutations accumulate in the various genes that control cell proliferation. Hence proliferation of cancer cell is not limited because of differing surface proteins and aberrant chromosomal complements. Thus, the correct answer is option D.

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