Closed head injury is the most common mechanism of TBI, accounting for approximately 80% of all cases.

The two main types of closed head injury are concussion and coup-contrecoup injury.

Excitotoxicity, or the excessive activation of glutamate receptors, is the primary mechanism of neuronal damage in TBI.

Inflammation is both protective and harmful in TBI. It helps to clear damaged tissue and promote healing, but it can also contribute to neuronal damage.

TBI can lead to a wide range of clinical consequences, including cognitive impairment, motor impairment, sensory impairment, and emotional and behavioral changes.

Memory loss is the most common type of cognitive impairment after TBI.

Hemiparesis, or weakness on one side of the body, is the most common type of motor impairment after TBI.

Somatosensory impairment, or loss of sensation in the skin, is the most common type of sensory impairment after TBI.

Depression, anxiety, irritability, and aggression are all common emotional and behavioral changes after TBI.

Secondary brain injury, which includes complications such as hypoxia, hypotension, and seizures, is the leading cause of death in TBI.

All of the factors listed are important in determining the outcome of TBI.

The goal of treatment for TBI is to prevent secondary brain injury, promote recovery of neuronal function, and improve the patient's quality of life.

The mainstays of treatment for TBI include surgery, medical management, and rehabilitation.

Surgery is used in TBI to remove blood clots from the brain, repair skull fractures, and relieve pressure on the brain.

Medical management in TBI is used to control intracranial pressure, prevent seizures, treat infections, and provide supportive care.

Rehabilitation in TBI is used to help patients regain lost function, improve their quality of life, and help them return to work or school.