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Purine Metabolism: Exploring the Pathways for Synthesizing and Degrading Purines

Description: Purine Metabolism Quiz: Test Your Understanding of Purine Synthesis and Degradation Pathways
Number of Questions: 15
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Tags: biochemistry purine metabolism nucleotides nitrogen metabolism
Attempted 0/15 Correct 0 Score 0

Which enzyme catalyzes the rate-limiting step in de novo purine biosynthesis?

  1. Phosphoribosyl pyrophosphate amidotransferase (PPAT)

  2. Glutamine phosphoribosyl pyrophosphate amidotransferase (GPAT)

  3. Inosine monophosphate dehydrogenase (IMPDH)

  4. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)


Correct Option: A
Explanation:

PPAT catalyzes the first step in de novo purine biosynthesis, which is the conversion of phosphoribosyl pyrophosphate (PRPP) to 5-phosphoribosyl-1-amine (PRA).

What is the immediate precursor of inosine monophosphate (IMP) in de novo purine biosynthesis?

  1. 5-Phosphoribosyl-1-amine (PRA)

  2. Glycinamide ribonucleotide (GAR)

  3. Succinyl-aminoimidazole carboxamide ribonucleotide (SAICAR)

  4. 5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR)


Correct Option: D
Explanation:

AICAR is the immediate precursor of IMP in de novo purine biosynthesis. It is formed by the cyclization of SAICAR.

Which enzyme catalyzes the conversion of IMP to adenosine monophosphate (AMP) and guanosine monophosphate (GMP)?

  1. Adenylosuccinate synthetase

  2. Adenylosuccinate lyase

  3. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

  4. Inosine monophosphate dehydrogenase (IMPDH)


Correct Option: A
Explanation:

Adenylosuccinate synthetase catalyzes the conversion of IMP to adenylosuccinate, which is then converted to AMP by adenylosuccinate lyase.

What is the final step in the de novo synthesis of purines?

  1. Conversion of IMP to AMP and GMP

  2. Conversion of PRA to GAR

  3. Conversion of SAICAR to AICAR

  4. Conversion of AICAR to IMP


Correct Option: A
Explanation:

The final step in de novo purine synthesis is the conversion of IMP to AMP and GMP by adenylosuccinate synthetase and adenylosuccinate lyase.

Which enzyme catalyzes the conversion of hypoxanthine to xanthine?

  1. Xanthine oxidase

  2. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

  3. Inosine monophosphate dehydrogenase (IMPDH)

  4. Adenylosuccinate synthetase


Correct Option: A
Explanation:

Xanthine oxidase catalyzes the conversion of hypoxanthine to xanthine, which is then converted to uric acid by uricase.

What is the final product of purine degradation?

  1. Hypoxanthine

  2. Xanthine

  3. Uric acid

  4. Allantoin


Correct Option: C
Explanation:

Uric acid is the final product of purine degradation in humans and other primates.

Which enzyme catalyzes the conversion of xanthine to uric acid?

  1. Xanthine oxidase

  2. Uricase

  3. Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)

  4. Inosine monophosphate dehydrogenase (IMPDH)


Correct Option: B
Explanation:

Uricase catalyzes the conversion of xanthine to uric acid.

What is the name of the enzyme that catalyzes the hydrolysis of adenosine to adenine and ribose-1-phosphate?

  1. Adenosine deaminase

  2. Adenosine kinase

  3. Adenosine phosphorylase

  4. Adenosine synthase


Correct Option: A
Explanation:

Adenosine deaminase catalyzes the hydrolysis of adenosine to adenine and ribose-1-phosphate.

Which enzyme catalyzes the conversion of guanine to xanthine?

  1. Guanine deaminase

  2. Guanine kinase

  3. Guanine phosphorylase

  4. Guanine synthase


Correct Option: A
Explanation:

Guanine deaminase catalyzes the conversion of guanine to xanthine.

What is the name of the enzyme that catalyzes the conversion of inosine to hypoxanthine?

  1. Inosine deaminase

  2. Inosine kinase

  3. Inosine phosphorylase

  4. Inosine synthase


Correct Option: A
Explanation:

Inosine deaminase catalyzes the conversion of inosine to hypoxanthine.

Which enzyme catalyzes the conversion of adenosine to inosine?

  1. Adenosine deaminase

  2. Adenosine kinase

  3. Adenosine phosphorylase

  4. Adenosine synthase


Correct Option: A
Explanation:

Adenosine deaminase catalyzes the conversion of adenosine to inosine.

What is the name of the enzyme that catalyzes the conversion of guanosine to guanine?

  1. Guanosine deaminase

  2. Guanosine kinase

  3. Guanosine phosphorylase

  4. Guanosine synthase


Correct Option: A
Explanation:

Guanosine deaminase catalyzes the conversion of guanosine to guanine.

Which enzyme catalyzes the conversion of xanthine to hypoxanthine?

  1. Xanthine oxidase

  2. Xanthine deaminase

  3. Xanthine kinase

  4. Xanthine phosphorylase


Correct Option: B
Explanation:

Xanthine deaminase catalyzes the conversion of xanthine to hypoxanthine.

What is the name of the enzyme that catalyzes the conversion of uric acid to allantoin?

  1. Uricase

  2. Allantoinase

  3. Allantoin kinase

  4. Allantoin phosphorylase


Correct Option: A
Explanation:

Uricase catalyzes the conversion of uric acid to allantoin.

Which enzyme catalyzes the conversion of allantoin to glyoxylate and urea?

  1. Allantoinase

  2. Allantoin kinase

  3. Allantoin phosphorylase

  4. Allantoin synthase


Correct Option: A
Explanation:

Allantoinase catalyzes the conversion of allantoin to glyoxylate and urea.

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