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Fatty Acid Oxidation: Unraveling the Process of Fat Breakdown for Energy Production

Description: Fatty Acid Oxidation: Unraveling the Process of Fat Breakdown for Energy Production
Number of Questions: 15
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Tags: biochemistry fatty acid metabolism energy production
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What is the primary role of fatty acid oxidation in cellular metabolism?

  1. Synthesis of new fatty acids

  2. Breakdown of fatty acids for energy production

  3. Regulation of cholesterol levels

  4. Transport of lipids across cell membranes


Correct Option: B
Explanation:

Fatty acid oxidation is a crucial metabolic pathway responsible for breaking down fatty acids into acetyl-CoA, which can then be further oxidized in the citric acid cycle to generate energy in the form of ATP.

Which enzyme initiates the process of fatty acid oxidation?

  1. Acetyl-CoA synthetase

  2. Carnitine palmitoyltransferase I (CPT I)

  3. 3-Hydroxyacyl-CoA dehydrogenase

  4. Enoyl-CoA hydratase


Correct Option: B
Explanation:

Carnitine palmitoyltransferase I (CPT I) is the enzyme that catalyzes the initial step of fatty acid oxidation, which is the transfer of long-chain fatty acids from the cytosol into the mitochondria.

What is the role of carnitine in fatty acid oxidation?

  1. Transport of fatty acids across the mitochondrial membrane

  2. Activation of fatty acids for oxidation

  3. Generation of acetyl-CoA from fatty acids

  4. Regulation of fatty acid oxidation


Correct Option: A
Explanation:

Carnitine acts as a carrier molecule that transports long-chain fatty acids across the mitochondrial membrane, allowing them to enter the mitochondria for oxidation.

Which of the following is a key intermediate in the beta-oxidation pathway?

  1. Acetyl-CoA

  2. Malonyl-CoA

  3. Citrate

  4. Oxaloacetate


Correct Option: A
Explanation:

Acetyl-CoA is a central intermediate in the beta-oxidation pathway, generated from the breakdown of fatty acids. It can then enter the citric acid cycle for further oxidation or be used in other metabolic processes.

What is the final product of complete fatty acid oxidation?

  1. Glucose

  2. Acetyl-CoA

  3. Carbon dioxide

  4. Water


Correct Option: C
Explanation:

Complete oxidation of fatty acids results in the production of carbon dioxide as the final product, along with water and energy in the form of ATP.

Which enzyme complex is responsible for the majority of the reactions in the beta-oxidation pathway?

  1. Pyruvate dehydrogenase complex

  2. Citrate synthase

  3. Fatty acid synthase

  4. Electron transport chain


Correct Option: C
Explanation:

Fatty acid synthase is the enzyme complex that catalyzes the majority of the reactions in the beta-oxidation pathway, including the dehydrogenation, hydration, and cleavage steps.

What is the name of the enzyme that catalyzes the dehydrogenation step in the beta-oxidation pathway?

  1. Acyl-CoA dehydrogenase

  2. Enoyl-CoA hydratase

  3. 3-Hydroxyacyl-CoA dehydrogenase

  4. Thiolase


Correct Option: A
Explanation:

Acyl-CoA dehydrogenase is the enzyme responsible for catalyzing the dehydrogenation step in the beta-oxidation pathway, converting acyl-CoA to enoyl-CoA.

Which coenzyme is required for the dehydrogenation step in the beta-oxidation pathway?

  1. NADH

  2. FAD

  3. CoQ10

  4. ATP


Correct Option: B
Explanation:

FAD (flavin adenine dinucleotide) is the coenzyme required for the dehydrogenation step in the beta-oxidation pathway, accepting electrons from acyl-CoA and transferring them to the electron transport chain.

What is the name of the enzyme that catalyzes the hydration step in the beta-oxidation pathway?

  1. Enoyl-CoA hydratase

  2. 3-Hydroxyacyl-CoA dehydrogenase

  3. Thiolase

  4. Citrate synthase


Correct Option: A
Explanation:

Enoyl-CoA hydratase is the enzyme responsible for catalyzing the hydration step in the beta-oxidation pathway, adding a water molecule to enoyl-CoA to form 3-hydroxyacyl-CoA.

Which coenzyme is required for the hydration step in the beta-oxidation pathway?

  1. NADH

  2. FAD

  3. CoQ10

  4. H2O


Correct Option: D
Explanation:

Water is the coenzyme required for the hydration step in the beta-oxidation pathway, adding a hydroxyl group to the double bond of enoyl-CoA.

What is the name of the enzyme that catalyzes the cleavage step in the beta-oxidation pathway?

  1. Thiolase

  2. Acyl-CoA dehydrogenase

  3. Enoyl-CoA hydratase

  4. 3-Hydroxyacyl-CoA dehydrogenase


Correct Option: A
Explanation:

Thiolase is the enzyme responsible for catalyzing the cleavage step in the beta-oxidation pathway, breaking down 3-hydroxyacyl-CoA into acetyl-CoA and a new acyl-CoA molecule.

How many rounds of beta-oxidation are required to completely oxidize a palmitic acid molecule?

  1. 7

  2. 8

  3. 9

  4. 10


Correct Option: A
Explanation:

Palmitic acid is a 16-carbon fatty acid, and each round of beta-oxidation removes two carbons. Therefore, 7 rounds of beta-oxidation are required to completely oxidize a palmitic acid molecule.

What is the name of the metabolic pathway that converts acetyl-CoA derived from fatty acid oxidation into glucose?

  1. Glycolysis

  2. Gluconeogenesis

  3. Glycogenesis

  4. Krebs cycle


Correct Option: B
Explanation:

Gluconeogenesis is the metabolic pathway that converts acetyl-CoA derived from fatty acid oxidation into glucose, allowing the body to produce glucose from non-carbohydrate sources.

Which hormone is primarily responsible for stimulating fatty acid oxidation in response to fasting or exercise?

  1. Insulin

  2. Glucagon

  3. Epinephrine

  4. Cortisol


Correct Option: B
Explanation:

Glucagon is the hormone primarily responsible for stimulating fatty acid oxidation in response to fasting or exercise, promoting the breakdown of stored triglycerides and the release of fatty acids into the bloodstream.

What is the name of the metabolic disorder characterized by an inability to properly oxidize fatty acids?

  1. Type 1 diabetes

  2. Type 2 diabetes

  3. Fatty liver disease

  4. Carnitine deficiency


Correct Option: D
Explanation:

Carnitine deficiency is a metabolic disorder characterized by an inability to properly oxidize fatty acids due to a lack of carnitine, which is essential for transporting fatty acids into the mitochondria for oxidation.

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