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Lipogenesis: Investigating the Synthesis of Fats from Acetyl-CoA

Description: Lipogenesis: Investigating the Synthesis of Fats from Acetyl-CoA
Number of Questions: 15
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Tags: biochemistry lipid metabolism fatty acid synthesis
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Which enzyme catalyzes the first committed step in lipogenesis?

  1. Acetyl-CoA carboxylase

  2. Fatty acid synthase

  3. Glycerol-3-phosphate acyltransferase

  4. Malonyl-CoA decarboxylase


Correct Option: A
Explanation:

Acetyl-CoA carboxylase converts acetyl-CoA to malonyl-CoA, which is the first committed step in lipogenesis.

What is the role of malonyl-CoA in lipogenesis?

  1. It is a substrate for fatty acid synthase

  2. It is a cofactor for acetyl-CoA carboxylase

  3. It is an inhibitor of fatty acid synthase

  4. It is a product of fatty acid synthase


Correct Option: A
Explanation:

Malonyl-CoA is a substrate for fatty acid synthase and is used to elongate the growing fatty acid chain.

Which enzyme catalyzes the condensation of malonyl-CoA with acetyl-CoA?

  1. Acetyl-CoA carboxylase

  2. Fatty acid synthase

  3. Glycerol-3-phosphate acyltransferase

  4. Malonyl-CoA decarboxylase


Correct Option: B
Explanation:

Fatty acid synthase catalyzes the condensation of malonyl-CoA with acetyl-CoA to form a four-carbon intermediate.

What is the role of NADPH in lipogenesis?

  1. It is a cofactor for acetyl-CoA carboxylase

  2. It is a cofactor for fatty acid synthase

  3. It is a cofactor for glycerol-3-phosphate acyltransferase

  4. It is a cofactor for malonyl-CoA decarboxylase


Correct Option: B
Explanation:

NADPH is a cofactor for fatty acid synthase and is used to reduce the growing fatty acid chain.

Which enzyme catalyzes the transfer of a fatty acid from acyl-CoA to glycerol-3-phosphate?

  1. Acetyl-CoA carboxylase

  2. Fatty acid synthase

  3. Glycerol-3-phosphate acyltransferase

  4. Malonyl-CoA decarboxylase


Correct Option: C
Explanation:

Glycerol-3-phosphate acyltransferase catalyzes the transfer of a fatty acid from acyl-CoA to glycerol-3-phosphate, forming a phosphatidic acid.

What is the role of phosphatidic acid in lipogenesis?

  1. It is a substrate for diacylglycerol acyltransferase

  2. It is a cofactor for acetyl-CoA carboxylase

  3. It is an inhibitor of fatty acid synthase

  4. It is a product of fatty acid synthase


Correct Option: A
Explanation:

Phosphatidic acid is a substrate for diacylglycerol acyltransferase and is used to form a triacylglycerol.

Which enzyme catalyzes the conversion of phosphatidic acid to diacylglycerol?

  1. Acetyl-CoA carboxylase

  2. Fatty acid synthase

  3. Glycerol-3-phosphate acyltransferase

  4. Phosphatidic acid phosphatase


Correct Option: D
Explanation:

Phosphatidic acid phosphatase catalyzes the conversion of phosphatidic acid to diacylglycerol by removing the phosphate group.

What is the role of diacylglycerol in lipogenesis?

  1. It is a substrate for triacylglycerol acyltransferase

  2. It is a cofactor for acetyl-CoA carboxylase

  3. It is an inhibitor of fatty acid synthase

  4. It is a product of fatty acid synthase


Correct Option: A
Explanation:

Diacylglycerol is a substrate for triacylglycerol acyltransferase and is used to form a triacylglycerol.

Which enzyme catalyzes the transfer of a fatty acid from acyl-CoA to diacylglycerol?

  1. Acetyl-CoA carboxylase

  2. Fatty acid synthase

  3. Glycerol-3-phosphate acyltransferase

  4. Triacylglycerol acyltransferase


Correct Option: D
Explanation:

Triacylglycerol acyltransferase catalyzes the transfer of a fatty acid from acyl-CoA to diacylglycerol, forming a triacylglycerol.

What is the role of triacylglycerol in lipogenesis?

  1. It is a storage form of fatty acids

  2. It is a cofactor for acetyl-CoA carboxylase

  3. It is an inhibitor of fatty acid synthase

  4. It is a product of fatty acid synthase


Correct Option: A
Explanation:

Triacylglycerol is a storage form of fatty acids and is the final product of lipogenesis.

Where does lipogenesis primarily occur in the body?

  1. Adipose tissue

  2. Liver

  3. Muscle

  4. Brain


Correct Option: A
Explanation:

Lipogenesis primarily occurs in adipose tissue, where fatty acids are stored as triacylglycerols.

What is the role of insulin in lipogenesis?

  1. It stimulates lipogenesis

  2. It inhibits lipogenesis

  3. It has no effect on lipogenesis

  4. It both stimulates and inhibits lipogenesis


Correct Option: A
Explanation:

Insulin stimulates lipogenesis by activating acetyl-CoA carboxylase and fatty acid synthase.

What is the role of glucagon in lipogenesis?

  1. It stimulates lipogenesis

  2. It inhibits lipogenesis

  3. It has no effect on lipogenesis

  4. It both stimulates and inhibits lipogenesis


Correct Option: B
Explanation:

Glucagon inhibits lipogenesis by inactivating acetyl-CoA carboxylase and fatty acid synthase.

What is the role of leptin in lipogenesis?

  1. It stimulates lipogenesis

  2. It inhibits lipogenesis

  3. It has no effect on lipogenesis

  4. It both stimulates and inhibits lipogenesis


Correct Option: B
Explanation:

Leptin inhibits lipogenesis by reducing the expression of acetyl-CoA carboxylase and fatty acid synthase.

What is the role of AMP-activated protein kinase (AMPK) in lipogenesis?

  1. It stimulates lipogenesis

  2. It inhibits lipogenesis

  3. It has no effect on lipogenesis

  4. It both stimulates and inhibits lipogenesis


Correct Option: B
Explanation:

AMPK inhibits lipogenesis by phosphorylating and inactivating acetyl-CoA carboxylase and fatty acid synthase.

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