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T Helper Cells and Their Subtypes

Description: T Helper Cells and Their Subtypes Quiz
Number of Questions: 15
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Tags: immunology t cells t helper cells
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What is the primary function of T helper cells?

  1. To directly kill infected cells

  2. To activate B cells for antibody production

  3. To secrete cytokines that regulate immune responses

  4. To phagocytose foreign particles

Show answer
Correct Option: C
Explanation:

T helper cells play a crucial role in coordinating immune responses by secreting cytokines that activate other immune cells, such as B cells, cytotoxic T cells, and macrophages.

Which cytokine is primarily produced by Th1 cells?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interferon-gamma (IFN-γ)

  4. Interleukin-17 (IL-17)

Show answer
Correct Option: C
Explanation:

Th1 cells are known for producing IFN-γ, which is a key cytokine involved in cell-mediated immunity and defense against intracellular pathogens.

What is the main function of Th2 cells?

  1. To activate cytotoxic T cells

  2. To promote antibody production by B cells

  3. To regulate inflammatory responses

  4. To directly kill infected cells

Show answer
Correct Option: B
Explanation:

Th2 cells play a crucial role in humoral immunity by promoting antibody production by B cells, which is essential for defense against extracellular pathogens.

Which cytokine is primarily produced by Th17 cells?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interleukin-17 (IL-17)

  4. Interferon-gamma (IFN-γ)

Show answer
Correct Option: C
Explanation:

Th17 cells are known for producing IL-17, which is a cytokine involved in promoting inflammation and defense against extracellular bacteria and fungi.

What is the role of T regulatory cells (Tregs) in the immune system?

  1. To activate B cells for antibody production

  2. To directly kill infected cells

  3. To suppress immune responses and maintain immune tolerance

  4. To secrete cytokines that promote inflammation

Show answer
Correct Option: C
Explanation:

Tregs play a crucial role in maintaining immune tolerance by suppressing immune responses and preventing excessive inflammation.

Which cytokine is primarily produced by Tregs?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interferon-gamma (IFN-γ)

  4. Interleukin-17 (IL-17)

Show answer
Correct Option: B
Explanation:

Tregs are known for producing IL-10, which is a cytokine that suppresses immune responses and promotes immune tolerance.

What is the main function of Th9 cells?

  1. To promote antibody production by B cells

  2. To activate cytotoxic T cells

  3. To regulate inflammatory responses

  4. To induce the differentiation of Th17 cells

Show answer
Correct Option: D
Explanation:

Th9 cells play a role in inducing the differentiation of Th17 cells, which are involved in promoting inflammation and defense against extracellular bacteria and fungi.

Which cytokine is primarily produced by Th22 cells?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interleukin-22 (IL-22)

  4. Interferon-gamma (IFN-γ)

Show answer
Correct Option: C
Explanation:

Th22 cells are known for producing IL-22, which is a cytokine involved in promoting tissue repair and defense against extracellular bacteria and fungi.

What is the role of follicular helper T cells (Tfh) in the immune system?

  1. To activate cytotoxic T cells

  2. To promote antibody production by B cells in germinal centers

  3. To regulate inflammatory responses

  4. To directly kill infected cells

Show answer
Correct Option: B
Explanation:

Tfh cells play a crucial role in promoting antibody production by B cells in germinal centers, which is essential for the generation of high-affinity antibodies.

Which cytokine is primarily produced by Tfh cells?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interferon-gamma (IFN-γ)

  4. Interleukin-21 (IL-21)

Show answer
Correct Option: D
Explanation:

Tfh cells are known for producing IL-21, which is a cytokine that promotes antibody production by B cells and the formation of germinal centers.

What is the function of type 1 regulatory T cells (Tr1 cells)?

  1. To promote antibody production by B cells

  2. To activate cytotoxic T cells

  3. To suppress immune responses and promote immune tolerance

  4. To directly kill infected cells

Show answer
Correct Option: C
Explanation:

Tr1 cells play a role in suppressing immune responses and promoting immune tolerance, particularly in the context of autoimmune diseases and transplantation.

Which cytokine is primarily produced by Tr1 cells?

  1. Interleukin-4 (IL-4)

  2. Interleukin-10 (IL-10)

  3. Interferon-gamma (IFN-γ)

  4. Interleukin-17 (IL-17)

Show answer
Correct Option: B
Explanation:

Tr1 cells are known for producing IL-10, which is a cytokine that suppresses immune responses and promotes immune tolerance.

What is the role of interleukin-2 (IL-2) in T helper cell differentiation?

  1. It promotes the differentiation of Th1 cells

  2. It promotes the differentiation of Th2 cells

  3. It promotes the differentiation of Th17 cells

  4. It promotes the differentiation of Tregs

Show answer
Correct Option: A
Explanation:

IL-2 is a cytokine that plays a crucial role in promoting the differentiation of Th1 cells, which are involved in cell-mediated immunity.

Which transcription factor is essential for the development of Th2 cells?

  1. T-bet

  2. GATA-3

  3. RORγt

  4. Foxp3

Show answer
Correct Option: B
Explanation:

GATA-3 is a transcription factor that is essential for the development and function of Th2 cells, which are involved in humoral immunity.

What is the role of retinoic acid (RA) in the differentiation of T helper cells?

  1. It promotes the differentiation of Th1 cells

  2. It promotes the differentiation of Th2 cells

  3. It promotes the differentiation of Th17 cells

  4. It promotes the differentiation of Tregs

Show answer
Correct Option: D
Explanation:

RA is a metabolite of vitamin A that plays a role in promoting the differentiation of Tregs, which are involved in immune tolerance.

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