Vaccines and Immunotherapy

Description: This quiz covers the fundamental concepts of Vaccines and Immunotherapy, including their mechanisms of action, types, and applications in disease prevention and treatment.
Number of Questions: 15
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Tags: vaccines immunotherapy immunity infectious diseases cancer
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What is the primary function of a vaccine?

  1. To treat an existing infection

  2. To provide temporary immunity against a disease

  3. To stimulate the immune system to produce antibodies

  4. To eliminate harmful bacteria from the body


Correct Option: C
Explanation:

Vaccines work by introducing weakened or inactivated forms of a pathogen into the body, triggering the immune system to produce antibodies and memory cells that protect against future infections.

Which type of vaccine contains live, attenuated pathogens?

  1. Inactivated vaccines

  2. Live attenuated vaccines

  3. Toxoid vaccines

  4. Subunit vaccines


Correct Option: B
Explanation:

Live attenuated vaccines contain weakened forms of the pathogen that are still capable of replicating, but are unable to cause disease. They provide long-lasting immunity and are commonly used for diseases such as measles, mumps, and rubella.

What is the mechanism of action of a toxoid vaccine?

  1. It stimulates the production of antibodies against toxins

  2. It prevents the replication of the pathogen

  3. It enhances the activity of phagocytes

  4. It directly kills the pathogen


Correct Option: A
Explanation:

Toxoid vaccines contain inactivated toxins produced by bacteria. They induce the immune system to produce antibodies that neutralize the toxins, preventing the development of disease symptoms.

Which type of vaccine is composed of purified components of a pathogen?

  1. Inactivated vaccines

  2. Live attenuated vaccines

  3. Toxoid vaccines

  4. Subunit vaccines


Correct Option: D
Explanation:

Subunit vaccines contain purified components, such as proteins or polysaccharides, derived from the pathogen. They are less likely to cause adverse reactions compared to live attenuated vaccines and are commonly used for diseases such as hepatitis B and influenza.

What is the primary goal of immunotherapy in cancer treatment?

  1. To stimulate the immune system to recognize and attack cancer cells

  2. To directly kill cancer cells

  3. To prevent the growth and spread of cancer cells

  4. To repair damaged DNA in cancer cells


Correct Option: A
Explanation:

Immunotherapy aims to harness the power of the immune system to fight cancer. It involves various approaches that enhance the immune system's ability to identify and destroy cancer cells.

Which type of immunotherapy involves the use of monoclonal antibodies?

  1. Adoptive cell therapy

  2. Immune checkpoint inhibitors

  3. Cancer vaccines

  4. Antibody-drug conjugates


Correct Option: D
Explanation:

Antibody-drug conjugates are a type of immunotherapy that combines a monoclonal antibody with a cytotoxic drug. The antibody targets specific molecules on cancer cells, delivering the drug directly to the cancer cells, resulting in their destruction.

What is the mechanism of action of immune checkpoint inhibitors?

  1. They stimulate the production of antibodies against cancer cells

  2. They enhance the activity of phagocytes

  3. They block inhibitory signals on immune cells, unleashing their anti-tumor response

  4. They directly kill cancer cells


Correct Option: C
Explanation:

Immune checkpoint inhibitors work by blocking inhibitory signals on immune cells, such as PD-1 and CTLA-4. This allows the immune cells to become more active and effectively target and destroy cancer cells.

Which type of immunotherapy involves the modification of a patient's own T cells to enhance their anti-tumor activity?

  1. Adoptive cell therapy

  2. Immune checkpoint inhibitors

  3. Cancer vaccines

  4. Antibody-drug conjugates


Correct Option: A
Explanation:

Adoptive cell therapy involves collecting and modifying a patient's own T cells, genetically engineering them to recognize and attack cancer cells, and then re-infusing them into the patient's body.

What is the primary function of cancer vaccines?

  1. To prevent the development of cancer

  2. To treat existing cancer

  3. To stimulate the immune system to recognize and attack cancer cells

  4. To directly kill cancer cells


Correct Option: C
Explanation:

Cancer vaccines aim to stimulate the immune system to recognize and attack cancer cells. They contain tumor-associated antigens or modified cancer cells that trigger an immune response against cancer.

Which type of immunotherapy involves the use of oncolytic viruses?

  1. Adoptive cell therapy

  2. Immune checkpoint inhibitors

  3. Virotherapy

  4. Antibody-drug conjugates


Correct Option: C
Explanation:

Virotherapy involves the use of oncolytic viruses, which are engineered to selectively infect and kill cancer cells while sparing healthy cells. The viruses replicate within cancer cells, causing their destruction and stimulating an immune response against cancer.

What is the primary function of adjuvant in vaccine formulation?

  1. To enhance the immunogenicity of the vaccine

  2. To reduce the risk of adverse reactions

  3. To stabilize the vaccine components

  4. To inactivate the pathogen in the vaccine


Correct Option: A
Explanation:

Adjuvants are substances added to vaccines to enhance the immune response. They stimulate the immune system to produce stronger and longer-lasting immunity against the pathogen.

Which type of vaccine is administered orally?

  1. Inactivated vaccines

  2. Live attenuated vaccines

  3. Toxoid vaccines

  4. Oral vaccines


Correct Option: D
Explanation:

Oral vaccines are administered through the mouth. They are typically used for diseases that are transmitted through the gastrointestinal tract, such as rotavirus and polio.

What is the primary function of memory cells in the immune response?

  1. To produce antibodies against pathogens

  2. To recognize and attack infected cells

  3. To provide long-term immunity against pathogens

  4. To activate complement proteins


Correct Option: C
Explanation:

Memory cells are a type of white blood cell that provides long-term immunity against pathogens. They are generated during an initial infection or vaccination and remain in the body, ready to quickly respond to future encounters with the same pathogen.

Which type of immunotherapy involves the use of genetically modified T cells to target cancer cells?

  1. Adoptive cell therapy

  2. Immune checkpoint inhibitors

  3. Cancer vaccines

  4. Antibody-drug conjugates


Correct Option: A
Explanation:

Adoptive cell therapy involves genetically modifying a patient's own T cells to express receptors that recognize specific antigens on cancer cells. These modified T cells are then re-infused into the patient's body, where they can effectively target and destroy cancer cells.

What is the primary function of herd immunity in the context of vaccination?

  1. To protect individuals who cannot be vaccinated

  2. To reduce the overall incidence of a disease in a population

  3. To stimulate the production of antibodies against a pathogen

  4. To prevent the emergence of new strains of a pathogen


Correct Option: B
Explanation:

Herd immunity occurs when a large proportion of a population is vaccinated, creating an indirect protection for individuals who are not vaccinated or cannot be vaccinated due to medical reasons. This reduces the overall incidence of the disease in the population.

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