Ototoxicity

Description: Ototoxicity Quiz: Test Your Knowledge of Ototoxic Drugs and Their Effects on Hearing
Number of Questions: 16
Created by:
Tags: audiology ototoxicity ototoxic drugs hearing loss vestibular toxicity
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Which of the following antibiotics is known to cause ototoxicity?

  1. Gentamicin

  2. Penicillin

  3. Amoxicillin

  4. Erythromycin


Correct Option: A
Explanation:

Gentamicin is an aminoglycoside antibiotic that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by aminoglycoside antibiotics?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Aminoglycoside antibiotics primarily cause ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is commonly used to treat malaria and can cause ototoxicity?

  1. Quinine

  2. Chloroquine

  3. Mefloquine

  4. Artemisinin


Correct Option: A
Explanation:

Quinine is an antimalarial drug that can cause ototoxicity, particularly at high doses or with prolonged use. It can affect the auditory nerve and cause hearing loss, especially in the high-frequency range.

What is the primary mechanism of ototoxicity caused by quinine?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: D
Explanation:

Quinine primarily causes ototoxicity by blocking ion channels in the cochlea, particularly the potassium channels. This disruption of ion balance can lead to hearing loss, especially in the high-frequency range.

Which of the following drugs is used to treat cancer and can cause ototoxicity?

  1. Cisplatin

  2. Carboplatin

  3. Paclitaxel

  4. Docetaxel


Correct Option: A
Explanation:

Cisplatin is a chemotherapy drug that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by cisplatin?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Cisplatin primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is used to treat tuberculosis and can cause ototoxicity?

  1. Streptomycin

  2. Isoniazid

  3. Rifampin

  4. Pyrazinamide


Correct Option: A
Explanation:

Streptomycin is an antibiotic used to treat tuberculosis that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by streptomycin?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Streptomycin primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is used to treat fungal infections and can cause ototoxicity?

  1. Amphotericin B

  2. Fluconazole

  3. Itraconazole

  4. Voriconazole


Correct Option: A
Explanation:

Amphotericin B is an antifungal drug that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by amphotericin B?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Amphotericin B primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is used to treat epilepsy and can cause ototoxicity?

  1. Phenytoin

  2. Carbamazepine

  3. Valproic acid

  4. Lamotrigine


Correct Option: A
Explanation:

Phenytoin is an anticonvulsant drug used to treat epilepsy that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by phenytoin?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Phenytoin primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is used to treat cancer and can cause ototoxicity?

  1. Methotrexate

  2. 5-Fluorouracil

  3. Doxorubicin

  4. Paclitaxel


Correct Option: A
Explanation:

Methotrexate is a chemotherapy drug used to treat cancer that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by methotrexate?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Methotrexate primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

Which of the following drugs is used to treat HIV/AIDS and can cause ototoxicity?

  1. Zidovudine

  2. Lamivudine

  3. Efavirenz

  4. Nevirapine


Correct Option: D
Explanation:

Nevirapine is an antiretroviral drug used to treat HIV/AIDS that can cause ototoxicity, particularly at high doses or with prolonged use. It can damage the hair cells in the inner ear, leading to hearing loss and balance problems.

What is the primary mechanism of ototoxicity caused by nevirapine?

  1. Interference with neurotransmitter release

  2. Inhibition of protein synthesis

  3. Damage to hair cells in the inner ear

  4. Blockage of ion channels in the cochlea


Correct Option: C
Explanation:

Nevirapine primarily causes ototoxicity by damaging the hair cells in the inner ear, which are responsible for hearing and balance. This damage can lead to hearing loss and vestibular dysfunction.

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