Cocaine is known to have the most significant negative impact on fertility in both men and women. It can lead to decreased sperm production, erectile dysfunction, and menstrual irregularities.

Alcohol consumption during pregnancy can lead to an increased risk of miscarriage, Fetal Alcohol Syndrome, premature birth, and other adverse outcomes.

Tobacco use is associated with an increased risk of ectopic pregnancy, a condition in which the fertilized egg implants outside the uterus.

Tetrahydrocannabinol (THC) is the primary psychoactive component of cannabis that affects the reproductive system.

Alcohol, tobacco, and cannabis can all cause erectile dysfunction.

Substance use during pregnancy can lead to an increased risk of birth defects, neonatal withdrawal syndrome, preterm birth, and other adverse outcomes in the newborn.

Cocaine use during pregnancy is associated with an increased risk of stillbirth.

Nicotine is the primary psychoactive component of tobacco that affects the reproductive system.

Alcohol, tobacco, and cannabis can all cause menstrual irregularities.

Substance use during pregnancy can lead to an increased risk of pregnancy complications, postpartum depression, long-term health problems, and other adverse outcomes in the mother.

Alcohol, tobacco, and cannabis can all increase the risk of miscarriage.

Ethanol is the primary psychoactive component of alcohol that affects the reproductive system.

Alcohol, tobacco, and cannabis can all increase the risk of premature birth.

Substance use during pregnancy can lead to an increased risk of learning disabilities, behavioral problems, physical health problems, and other adverse outcomes in the child.

Alcohol, tobacco, and cannabis can all increase the risk of low birth weight.