Antidepressants are not typically used to manage pain, although they may be used to treat depression, which can sometimes accompany pain.

Opioids bind to opioid receptors in the central nervous system, which reduces the perception of pain.

Nausea and vomiting, constipation, and drowsiness are all common side effects of opioids.

NSAIDs inhibit the activity of cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins, which are involved in the inflammatory process.

Gastrointestinal upset, headache, and dizziness are all common side effects of NSAIDs.

Antidepressants block the reuptake of serotonin and norepinephrine, which increases the levels of these neurotransmitters in the synaptic cleft, which can help to reduce pain.

Nausea and vomiting, constipation, and drowsiness are all common side effects of antidepressants.

Anticonvulsants stabilize neuronal membranes, which can help to reduce the frequency and severity of pain signals.

Dizziness, ataxia, and somnolence are all common side effects of anticonvulsants.

Severe respiratory depression, uncontrolled seizures, and history of opioid abuse are all contraindications to the use of opioids.

Active peptic ulcer disease, history of gastrointestinal bleeding, and severe renal impairment are all contraindications to the use of NSAIDs.

Untreated bipolar disorder, history of serotonin syndrome, and concurrent use of monoamine oxidase inhibitors (MAOIs) are all contraindications to the use of antidepressants.

History of liver failure, history of bone marrow suppression, and concurrent use of other CNS depressants are all contraindications to the use of anticonvulsants.

NSAIDs are the most common type of pain management drug.

Opioids are the most likely pain management drug to cause addiction.