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Biophysics of Metabolic Diseases

Description: This quiz covers the fundamental concepts and mechanisms underlying the biophysics of metabolic diseases.
Number of Questions: 15
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Tags: biophysics metabolic diseases biochemistry physiology
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What is the primary role of insulin in the regulation of glucose metabolism?

  1. Stimulates glucose uptake by cells

  2. Inhibits glucose production by the liver

  3. Promotes the storage of glucose as glycogen

  4. All of the above


Correct Option: D
Explanation:

Insulin acts as a key regulator of glucose metabolism by promoting glucose uptake by cells, inhibiting glucose production by the liver, and facilitating the storage of glucose as glycogen.

Which hormone is primarily responsible for regulating blood glucose levels during fasting?

  1. Insulin

  2. Glucagon

  3. Somatostatin

  4. Ghrelin


Correct Option: B
Explanation:

Glucagon is the primary hormone that counteracts the effects of insulin during fasting. It stimulates the liver to produce glucose through glycogenolysis and gluconeogenesis, thereby maintaining blood glucose levels.

What is the main function of the electron transport chain in cellular respiration?

  1. Generation of ATP through oxidative phosphorylation

  2. Production of NADH and FADH2

  3. Transfer of electrons from NADH and FADH2 to oxygen

  4. All of the above


Correct Option: D
Explanation:

The electron transport chain is a series of protein complexes located in the inner mitochondrial membrane. Its primary function is to generate ATP through oxidative phosphorylation, which involves the transfer of electrons from NADH and FADH2 to oxygen, resulting in the production of water.

Which metabolic pathway is responsible for the breakdown of glucose to produce pyruvate?

  1. Glycolysis

  2. Gluconeogenesis

  3. Glycogenolysis

  4. Krebs cycle


Correct Option: A
Explanation:

Glycolysis is the metabolic pathway that occurs in the cytoplasm of cells and involves the breakdown of glucose into pyruvate. It is the first step in the process of cellular respiration.

What is the primary function of the Krebs cycle in cellular respiration?

  1. Generation of ATP through oxidative phosphorylation

  2. Production of NADH and FADH2

  3. Complete oxidation of acetyl-CoA derived from glucose

  4. All of the above


Correct Option: D
Explanation:

The Krebs cycle, also known as the citric acid cycle or tricarboxylic acid cycle, is a series of chemical reactions that occur in the mitochondria of cells. Its primary function is to completely oxidize acetyl-CoA derived from glucose, producing NADH and FADH2, which are used in the electron transport chain to generate ATP.

Which hormone is primarily responsible for stimulating lipolysis in adipose tissue?

  1. Insulin

  2. Glucagon

  3. Epinephrine

  4. Somatostatin


Correct Option: C
Explanation:

Epinephrine, also known as adrenaline, is a hormone that plays a key role in the regulation of lipolysis in adipose tissue. It stimulates the breakdown of triglycerides into glycerol and fatty acids, releasing them into the bloodstream for energy production.

What is the main function of glycogen in the liver?

  1. Storage of glucose for energy production

  2. Regulation of blood glucose levels

  3. Gluconeogenesis

  4. All of the above


Correct Option: D
Explanation:

Glycogen is a complex carbohydrate stored in the liver and muscles. Its primary function is to serve as a storage form of glucose for energy production. Additionally, glycogen plays a crucial role in regulating blood glucose levels by releasing glucose into the bloodstream when needed.

Which metabolic pathway is responsible for the conversion of fatty acids into ketone bodies?

  1. Glycolysis

  2. Gluconeogenesis

  3. Glycogenolysis

  4. Ketogenesis


Correct Option: D
Explanation:

Ketogenesis is the metabolic pathway that occurs in the liver during periods of prolonged fasting or starvation. It involves the breakdown of fatty acids into ketone bodies, which can be used as an alternative fuel source for the brain and other tissues.

What is the primary role of the thyroid hormones in metabolic regulation?

  1. Stimulation of basal metabolic rate

  2. Regulation of body temperature

  3. Control of growth and development

  4. All of the above


Correct Option: D
Explanation:

Thyroid hormones, including thyroxine (T4) and triiodothyronine (T3), play a crucial role in metabolic regulation. They stimulate the basal metabolic rate, regulate body temperature, and control growth and development.

Which hormone is primarily responsible for regulating calcium and phosphate metabolism?

  1. Insulin

  2. Glucagon

  3. Parathyroid hormone

  4. Somatostatin


Correct Option: C
Explanation:

Parathyroid hormone (PTH) is the primary hormone responsible for regulating calcium and phosphate metabolism. It acts on the bones, kidneys, and intestines to maintain calcium and phosphate homeostasis.

What is the main function of the sodium-potassium pump in cellular transport?

  1. Maintenance of the cell membrane potential

  2. Active transport of sodium and potassium ions

  3. Regulation of cell volume

  4. All of the above


Correct Option: D
Explanation:

The sodium-potassium pump, also known as the Na+/K+-ATPase, is a membrane protein that plays a crucial role in cellular transport. It actively transports sodium and potassium ions across the cell membrane, maintaining the cell membrane potential, regulating cell volume, and facilitating the transport of other molecules.

Which metabolic pathway is responsible for the conversion of amino acids into glucose?

  1. Glycolysis

  2. Gluconeogenesis

  3. Glycogenolysis

  4. Ketogenesis


Correct Option: B
Explanation:

Gluconeogenesis is the metabolic pathway that occurs in the liver and kidneys during fasting or starvation. It involves the conversion of non-carbohydrate substrates, such as amino acids and glycerol, into glucose.

What is the primary function of the liver in metabolic regulation?

  1. Storage and release of glucose

  2. Detoxification of harmful substances

  3. Production of bile for digestion

  4. All of the above


Correct Option: D
Explanation:

The liver plays a central role in metabolic regulation. It stores and releases glucose, detoxifies harmful substances, produces bile for digestion, and performs numerous other metabolic functions.

Which hormone is primarily responsible for regulating appetite and satiety?

  1. Insulin

  2. Glucagon

  3. Leptin

  4. Somatostatin


Correct Option: C
Explanation:

Leptin is a hormone produced by adipose tissue that plays a crucial role in regulating appetite and satiety. It signals the brain to suppress hunger and increase energy expenditure.

What is the main function of the pancreas in metabolic regulation?

  1. Production of insulin and glucagon

  2. Secretion of digestive enzymes

  3. Regulation of blood glucose levels

  4. All of the above


Correct Option: D
Explanation:

The pancreas is a vital organ involved in metabolic regulation. It produces insulin and glucagon, which regulate blood glucose levels, secretes digestive enzymes for the breakdown of food, and plays a role in maintaining electrolyte balance.

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