Black is a 2005 Indian drama film directed by Sanjay Leela Bhansali and starring Amitabh Bachchan and Rani Mukerji. The film tells the story of a deaf and blind girl and her relationship with her teacher.

Amitabh Bachchan won the National Film Award for Best Actor for his portrayal of a character with autism in the 2010 film Paa.

Kangana Ranaut won the National Film Award for Best Actress for her portrayal of a character with schizophrenia in the 2014 film Queen.

Mukti Bhawan is a 2017 Indian drama film directed by Shubhashish Bhutiani and starring Lalit Behl, Geetanjali Kulkarni, and Adil Hussain. The film tells the story of a terminally ill man who travels to Varanasi to die.

Ayushmann Khurrana won the Filmfare Award for Best Actor for his portrayal of a character with erectile dysfunction in the 2018 film Shubh Mangal Saavdhan.

Alia Bhatt won the Filmfare Award for Best Actress for her portrayal of a character with bipolar disorder in the 2018 film Raazi.

Thappad is a 2020 Indian drama film directed by Anubhav Sinha and starring Taapsee Pannu, Pavail Gulati, Dia Mirza, Ratna Pathak Shah, Tanvi Azmi, Kumud Mishra, and Maya Sarao. The film tells the story of a woman who files for divorce after her husband slaps her.

Ayushmann Khurrana won the IIFA Award for Best Actor for his portrayal of a character with cerebral palsy in the 2020 film Shubh Mangal Zyada Saavdhan.

Alia Bhatt won the IIFA Award for Best Actress for her portrayal of a character with PTSD in the 2022 film Gangubai Kathiawadi.

Jhund is a 2022 Indian sports drama film directed by Nagraj Manjule and starring Amitabh Bachchan, Akash Thosar, and Rinku Rajguru. The film tells the story of a retired sports teacher who starts a football team for street children.

Ayushmann Khurrana won the Zee Cine Award for Best Actor for his portrayal of a character with Tourette syndrome in the 2023 film Doctor G.

Alia Bhatt won the Zee Cine Award for Best Actress for her portrayal of a character with multiple sclerosis in the 2024 film Darlings.

Badhaai Do is a 2022 Indian comedy-drama film directed by Harshavardhan Kulkarni and starring Rajkummar Rao, Bhumi Pednekar, Chum Darang, Seema Pahwa, Sheeba Chaddha, Loveleen Mishra, Nitish Pandey, and Shashi Bhushan. The film tells the story of a gay man and a lesbian woman who enter into a lavender marriage to appease their families.

Ayushmann Khurrana won the Star Screen Award for Best Actor for his portrayal of a character with autism in the 2026 film Anek.

Alia Bhatt won the Star Screen Award for Best Actress for her portrayal of a character with bipolar disorder in the 2027 film Jee Le Zaraa.