The primary ethical principle that governs human experimentation is autonomy, which refers to the right of individuals to make their own decisions about their participation in research studies.

The purpose of informed consent in human experimentation is to ensure that participants are aware of the risks and benefits of the study, to obtain their permission to participate in the study, and to protect their rights.

The role of ethics committees in human experimentation is to review and approve research proposals, to monitor the conduct of research studies, and to provide guidance to researchers on ethical issues.

The difference between a clinical trial and a non-clinical trial is that clinical trials involve human participants, while non-clinical trials do not; clinical trials are designed to test the safety and efficacy of new drugs or treatments, while non-clinical trials are not; and clinical trials are subject to more stringent ethical regulations than non-clinical trials.

Some of the ethical issues that arise in human experimentation include the potential for harm to participants, the lack of informed consent, the exploitation of vulnerable populations, and the conflict of interest between researchers and participants.

Some of the ways to minimize the risks of harm to participants in human experimentation include obtaining informed consent, conducting a thorough risk-benefit analysis, and monitoring participants closely for adverse events.

The role of the researcher in human experimentation is to design and conduct the study, to obtain informed consent from participants, and to monitor participants for adverse events.

The role of the participant in human experimentation is to provide informed consent, to follow the study protocol, and to report any adverse events to the researcher.

Some of the challenges to conducting ethical human experimentation include the difficulty of obtaining informed consent from vulnerable populations, the potential for conflicts of interest between researchers and participants, and the lack of resources to conduct research in a safe and ethical manner.

Some of the recent developments in the ethics of human experimentation include the development of new guidelines for informed consent, the increasing use of ethics committees to review research proposals, and the growing emphasis on the importance of public engagement in research.