Black is a 2005 Indian drama film directed by Sanjay Leela Bhansali, which features Rani Mukerji as a deaf and blind woman and Amitabh Bachchan as her teacher.

Ethan Mascarenhas is a quadriplegic magician who files a petition for euthanasia in the film Guzaarish.

Kalki Koechlin portrayed the character of Laila, a woman with cerebral palsy, in the 2015 film Margarita with a Straw.

Secret Superstar is a 2017 Indian musical drama film directed by Advait Chandan, which features Zaira Wasim as a young girl with Down syndrome who dreams of becoming a singer.

Iqbal is a 2005 Indian sports drama film directed by Nagesh Kukunoor, which is based on the true story of a visually impaired cricketer named Mohammad Iqbal.

Ayushmann Khurrana played the role of Akash, a blind pianist who pretends to be visually impaired in the 2018 film Andhadhun.

Amitabh Bachchan portrayed the character of Badal Gupta, a lawyer who is visually impaired, in the 2019 film Badla.

Vidya Balan played the role of Shakuntala Devi, a mathematician and astrologer who was diagnosed with multiple sclerosis, in the 2020 film Shakuntala Devi.

Jhund is a 2021 Indian sports drama film directed by Nagraj Manjule, which features Amitabh Bachchan as a retired sports teacher who forms a football team with street children, including one with autism.

ABCD is a 2013 Indian dance film directed by Remo D'Souza, which is loosely based on the true story of a hearing-impaired dancer named Vernon Monteiro.

Ranbir Kapoor played the role of Balli, a dacoit who is deaf and mute, in the 2022 film Shamshera.

Shefali Shah portrayed the character of Shamshunissa Ansari, a woman with cerebral palsy, in the 2022 film Darlings.

Bhediya is a 2023 Indian horror comedy film directed by Amar Kaushik, which features Varun Dhawan as a man who turns into a werewolf after being bitten by a wolf.

Soorarai Pottru is a 2020 Indian Tamil-language biographical drama film directed by Sudha Kongara, which is based on the true story of G. R. Gopinath, a visually impaired entrepreneur who founded the low-cost airline Air Deccan.

Dhanush played the role of Balu, a hearing-impaired teacher, in the 2023 film Vaathi.