Decellularization and Extracellular Matrix Engineering Online Test

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Decellularization and Extracellular Matrix Engineering

Description: This quiz covers the concepts and techniques of decellularization and extracellular matrix engineering, including the methods, applications, and challenges in this field.
Number of Questions: 15
Created by: Aliensbrain Bot
Tags: decellularization extracellular matrix engineering tissue engineering biomaterials

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What is the primary goal of decellularization?

To remove all cellular components from a tissue or organ.
To preserve the extracellular matrix (ECM) structure and composition.
To create a scaffold for cell growth and tissue regeneration.
All of the above.

Which method of decellularization utilizes detergents to dissolve cell membranes?

Physical decellularization
Chemical decellularization
Enzymatic decellularization
Supercritical fluid decellularization

What is the role of enzymes in enzymatic decellularization?

To break down the ECM structure.
To dissolve cell membranes.
To remove cellular debris.
To sterilize the decellularized tissue.

Which decellularization method employs high pressure and carbon dioxide to remove cellular components?

Physical decellularization
Chemical decellularization
Enzymatic decellularization
Supercritical fluid decellularization

What is the main challenge associated with physical decellularization methods?

Harsh conditions can damage the ECM.
Residual cellular components can compromise biocompatibility.
The process is time-consuming and requires specialized equipment.
All of the above.

Which decellularization method is commonly used for tissues with delicate ECM structures?

Physical decellularization
Chemical decellularization
Enzymatic decellularization
Supercritical fluid decellularization

What is the primary function of the extracellular matrix (ECM) in tissue engineering?

To provide structural support to cells.
To regulate cell migration and differentiation.
To facilitate cell-cell communication.
All of the above.

Which component of the ECM is responsible for providing tensile strength and elasticity?

Collagen
Elastin
Glycosaminoglycans
Proteoglycans

What is the role of glycosaminoglycans (GAGs) in the ECM?

To provide hydration and lubrication.
To regulate cell migration and differentiation.
To facilitate cell-cell communication.
All of the above.

Which cell type is commonly used for recellularization of decellularized scaffolds?

Stem cells
Primary cells
Immortalized cell lines
All of the above.

What is the main challenge associated with recellularization of decellularized scaffolds?

Ensuring uniform cell distribution throughout the scaffold.
Promoting cell attachment and survival within the scaffold.
Maintaining cell viability and functionality after recellularization.
All of the above.

What is the purpose of extracellular matrix (ECM) engineering?

To modify the ECM composition and structure for specific applications.
To improve the biocompatibility and functionality of biomaterials.
To create synthetic ECM scaffolds for tissue regeneration.
All of the above.

Which technique is commonly used to modify the ECM composition and structure?

Genetic engineering
Chemical crosslinking
Decellularization
All of the above.

What is the primary goal of chemical crosslinking in ECM engineering?

To increase the mechanical strength of the ECM.
To improve the biocompatibility of the ECM.
To enhance cell attachment and migration.
All of the above.

Which biomaterial is commonly used to create synthetic ECM scaffolds?

Collagen
Hyaluronic acid
Fibrin
All of the above.

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