The Choctaw were the first Native American tribe to settle in the Mississippi River Valley. They arrived in the area around 1000 CE and established a large and powerful chiefdom.

Hernando de Soto was the first European explorer to reach the Mississippi River. He arrived in the area in 1541 and explored the river for several months.

Robert de La Salle was the French explorer who claimed the Mississippi River Valley for France. He arrived in the area in 1682 and explored the river for several months. He then built a fort at the mouth of the Mississippi River and claimed the entire valley for France.

Georgia was the first British colony to settle in the Mississippi River Valley. The colony was founded in 1732 by James Oglethorpe. Oglethorpe and his followers settled in the area around Savannah, Georgia.

Thomas Jefferson was the American president who acquired the Louisiana Territory from France. He purchased the territory in 1803 for $15 million. The Louisiana Purchase doubled the size of the United States and gave the country control of the Mississippi River.

The Battle of Vicksburg was a major battle of the Civil War that was fought in the Mississippi River Valley. The battle lasted for 47 days and resulted in a Union victory. The Union victory at Vicksburg gave the Union control of the Mississippi River and split the Confederacy in two.

St. Louis, Missouri is known as the "Gateway to the West". The city was founded in 1764 by French fur traders and quickly became a major center of trade and commerce. St. Louis was the starting point for many westward expeditions, including the Lewis and Clark Expedition.

The Missouri River is the longest tributary of the Mississippi River. The river is 2,341 miles long and flows through six states. The Missouri River joins the Mississippi River at St. Louis, Missouri.

St. Louis, Missouri is located at the confluence of the Mississippi and Missouri rivers. The city was founded in 1764 by French fur traders and quickly became a major center of trade and commerce. St. Louis was the starting point for many westward expeditions, including the Lewis and Clark Expedition.

The Mississippi River is known as the "Father of Waters". The river is the longest river in North America and flows through 10 states. The Mississippi River is a vital waterway for transportation and commerce.

New Orleans, Louisiana is located at the mouth of the Mississippi River. The city was founded in 1718 by French colonists. New Orleans is a major port city and is known for its vibrant culture and cuisine.

The Mississippi River Flood Control System was built to protect the Mississippi River Valley from flooding. The system was built in the 1920s and 1930s and consists of a series of levees, floodwalls, and floodways. The system has been successful in reducing flooding in the Mississippi River Valley.

The Deepwater Horizon oil spill was an environmental disaster that occurred in the Mississippi River Valley in 2010. The spill occurred when an oil rig exploded in the Gulf of Mexico. The spill released millions of gallons of oil into the Gulf of Mexico and caused widespread damage to the environment.

The Mississippi River is known as the "Mighty Mississippi". The river is the longest river in North America and flows through 10 states. The Mississippi River is a vital waterway for transportation and commerce.