Pratitya-samutpada emphasizes the interconnectedness and interdependence of all phenomena. It asserts that nothing exists independently, but rather arises and exists in relation to other factors and conditions.

The Mahayana school of Buddhism, particularly the Madhyamaka and Yogacara traditions, played a significant role in the development and articulation of Pratitya-samutpada. These traditions emphasized the emptiness (shunyata) of all phenomena and the interconnectedness of all things.

Pratitya-samutpada provides a framework for understanding how actions (karma) lead to consequences. It shows how the actions of an individual in one moment can have far-reaching effects in subsequent moments, creating a chain of cause and effect.

Pratitya-samutpada challenges the idea of a permanent, unchanging self by showing that all phenomena, including the self, are impermanent and subject to change. It argues that the self is not a fixed entity but rather a collection of interconnected and constantly changing factors.

The twelve links of Pratitya-samutpada outline the causal chain that leads from ignorance to suffering. They show how one factor gives rise to another, creating a cycle of cause and effect that perpetuates suffering.

In Mahayana Buddhism, emptiness (shunyata) is the ultimate reality, and all phenomena are empty of inherent existence. Pratitya-samutpada is seen as a manifestation of emptiness, as it shows how all phenomena arise and exist in dependence on other phenomena, without any independent self-nature.

Pratitya-samutpada is a fundamental principle in meditation and mindfulness practices. By contemplating the interconnectedness of all phenomena, practitioners can cultivate a sense of compassion and understanding towards themselves and others, and develop a deeper appreciation for the beauty and complexity of the world.

Pratitya-samutpada challenges the idea of a linear and deterministic view of time by showing that all phenomena are interconnected and interdependent. This means that the present moment is influenced by the past and has implications for the future, creating a web of interconnectedness that transcends linear time.

Pratitya-samutpada can be applied to contemporary issues such as climate change and social justice by highlighting the interconnectedness of ecological and social systems. It shows how actions in one domain can have far-reaching consequences in other domains, emphasizing the need for a holistic and compassionate approach to addressing these challenges.

Pratitya-samutpada suggests that the mind and body are interconnected and interdependent. It shows how mental states can influence physical states and vice versa, emphasizing the psychosomatic nature of human experience.