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Drug Interactions and Polypharmacy in Psychopharmacology

Description: This quiz is designed to assess your understanding of drug interactions and polypharmacy in psychopharmacology.
Number of Questions: 15
Created by:
Tags: psychopharmacology drug interactions polypharmacy
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Which of the following drugs is known to interact with MAOIs, potentially causing a hypertensive crisis?

  1. Tricyclic antidepressants

  2. Selective serotonin reuptake inhibitors (SSRIs)

  3. Benzodiazepines

  4. Antipsychotics


Correct Option: A
Explanation:

MAOIs can interact with tricyclic antidepressants, leading to a hypertensive crisis due to the accumulation of norepinephrine and serotonin.

What is the term used to describe the combined use of multiple medications to treat a single condition?

  1. Polypharmacy

  2. Monotherapy

  3. Combination therapy

  4. Sequential therapy


Correct Option: A
Explanation:

Polypharmacy refers to the simultaneous use of multiple medications to treat a single condition.

Which of the following drug combinations can lead to serotonin syndrome?

  1. MAOIs and SSRIs

  2. SSRIs and tricyclic antidepressants

  3. Antipsychotics and mood stabilizers

  4. Benzodiazepines and anticonvulsants


Correct Option: A
Explanation:

The combination of MAOIs and SSRIs can lead to serotonin syndrome, a potentially life-threatening condition characterized by hyperthermia, agitation, and muscle rigidity.

What is the primary mechanism of action of cytochrome P450 enzymes in drug metabolism?

  1. Oxidation

  2. Reduction

  3. Hydrolysis

  4. Glucuronidation


Correct Option: A
Explanation:

Cytochrome P450 enzymes primarily metabolize drugs through oxidation reactions.

Which of the following drugs is a potent inducer of cytochrome P450 enzymes?

  1. Phenobarbital

  2. Carbamazepine

  3. Valproate

  4. Lithium


Correct Option: A
Explanation:

Phenobarbital is a potent inducer of cytochrome P450 enzymes, which can lead to increased metabolism and decreased effectiveness of other drugs.

What is the term used to describe the decreased effectiveness of a drug due to the presence of another drug?

  1. Drug-drug interaction

  2. Polypharmacy

  3. Pharmacokinetic interaction

  4. Pharmacodynamic interaction


Correct Option: C
Explanation:

A pharmacokinetic interaction occurs when one drug alters the absorption, distribution, metabolism, or excretion of another drug, leading to changes in its concentration and effectiveness.

Which of the following drugs is known to inhibit cytochrome P450 enzymes, potentially leading to increased drug concentrations and toxicity?

  1. Erythromycin

  2. Rifampin

  3. Fluoxetine

  4. Lamotrigine


Correct Option: A
Explanation:

Erythromycin is a potent inhibitor of cytochrome P450 enzymes, which can lead to increased concentrations and toxicity of other drugs metabolized by these enzymes.

What is the term used to describe the increased effectiveness of a drug due to the presence of another drug?

  1. Drug-drug interaction

  2. Polypharmacy

  3. Pharmacokinetic interaction

  4. Pharmacodynamic interaction


Correct Option: D
Explanation:

A pharmacodynamic interaction occurs when one drug alters the response of the body to another drug, leading to changes in its effectiveness.

Which of the following drug combinations can lead to increased risk of seizures?

  1. Lithium and valproate

  2. Lamotrigine and topiramate

  3. Carbamazepine and phenytoin

  4. Gabapentin and pregabalin


Correct Option: C
Explanation:

The combination of carbamazepine and phenytoin can increase the risk of seizures due to their additive effects on lowering the seizure threshold.

What is the term used to describe the use of two or more drugs with different mechanisms of action to achieve a synergistic effect?

  1. Polypharmacy

  2. Combination therapy

  3. Sequential therapy

  4. Augmentation therapy


Correct Option: B
Explanation:

Combination therapy involves the use of two or more drugs with different mechanisms of action to achieve a synergistic effect.

Which of the following drug combinations can lead to increased risk of QT prolongation and torsades de pointes?

  1. Lithium and haloperidol

  2. Quetiapine and risperidone

  3. Olanzapine and clozapine

  4. Aripiprazole and ziprasidone


Correct Option: A
Explanation:

The combination of lithium and haloperidol can increase the risk of QT prolongation and torsades de pointes, potentially leading to cardiac arrhythmias.

What is the term used to describe the use of a drug to reduce or eliminate the adverse effects of another drug?

  1. Polypharmacy

  2. Combination therapy

  3. Sequential therapy

  4. Augmentation therapy


Correct Option: D
Explanation:

Augmentation therapy involves the use of a drug to reduce or eliminate the adverse effects of another drug.

Which of the following drug combinations can lead to increased risk of neuroleptic malignant syndrome (NMS)?

  1. Antipsychotics and lithium

  2. Antipsychotics and antidepressants

  3. Antipsychotics and benzodiazepines

  4. Antipsychotics and anticonvulsants


Correct Option: A
Explanation:

The combination of antipsychotics and lithium can increase the risk of neuroleptic malignant syndrome (NMS), a potentially life-threatening condition characterized by hyperthermia, muscle rigidity, and altered mental status.

What is the term used to describe the use of a drug to enhance the effectiveness of another drug?

  1. Polypharmacy

  2. Combination therapy

  3. Sequential therapy

  4. Augmentation therapy


Correct Option: D
Explanation:

Augmentation therapy involves the use of a drug to enhance the effectiveness of another drug.

Which of the following drug combinations can lead to increased risk of tardive dyskinesia (TD)?

  1. Antipsychotics and lithium

  2. Antipsychotics and antidepressants

  3. Antipsychotics and benzodiazepines

  4. Antipsychotics and anticonvulsants


Correct Option: A
Explanation:

The combination of antipsychotics and lithium can increase the risk of tardive dyskinesia (TD), a movement disorder characterized by involuntary muscle movements.

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