Cyclosporine, tacrolimus, and azathioprine are all immunosuppressive drugs used to prevent rejection in organ transplantation.

Cyclosporine inhibits calcineurin, a phosphatase that is essential for T cell activation.

Tacrolimus inhibits calcineurin, a phosphatase that is essential for T cell activation.

Azathioprine inhibits purine synthesis, which is essential for DNA and RNA synthesis.

Cyclosporine can cause nephrotoxicity, neurotoxicity, and hepatotoxicity.

Tacrolimus can cause nephrotoxicity, neurotoxicity, and hepatotoxicity.

Azathioprine can cause myelosuppression, gastrointestinal upset, and hepatotoxicity.

Cyclosporine is contraindicated in patients with active infection, malignancy, or pregnancy.

Tacrolimus is contraindicated in patients with active infection, malignancy, or pregnancy.

Azathioprine is contraindicated in patients with active infection, malignancy, or pregnancy.

Methotrexate, leflunomide, and mycophenolate mofetil are all immunosuppressive drugs used to treat autoimmune diseases.

Methotrexate inhibits dihydrofolate reductase, an enzyme that is essential for DNA synthesis.

Leflunomide inhibits dihydroorotate dehydrogenase, an enzyme that is essential for pyrimidine synthesis.

Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase, an enzyme that is essential for guanine synthesis.

Methotrexate can cause myelosuppression, gastrointestinal upset, and hepatotoxicity.

Leflunomide can cause gastrointestinal upset, hepatotoxicity, and neurotoxicity.

Mycophenolate mofetil can cause myelosuppression, gastrointestinal upset, and hepatotoxicity.