Antibodies and antitoxin - class-XII
Description: antibodies and antitoxin | |
Number of Questions: 56 | |
Created by: Tanuja Atwal | |
Tags: human health and disease bio-chemistry human physiology health and disease biology animal physiology cell biology and biotechnology aids to health immunology diseases and immunity |
People administered with preformed antibodies get
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active immunity
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innate immunity
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natural immunity
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passive immunity
The immune system, which is made up of special cells, proteins, tissues, and organs, defends people against germs and microorganisms every day. In most cases, the immune system does a great job of keeping people healthy and preventing infections. But sometimes problems with the immune system can lead to illness and infection. The immune system is the body's defense against infectious organisms and other invaders. Through a series of steps called the immune response, the immune system attacks organisms and substances that invade body systems and cause disease. antibodies can activate a group of proteins called complement that are also part of the immune system. Complement assists in killing bacteria, viruses, or infected cells. All of these specialized cells and parts of the immune system offer the body protection against disease. This protection is called immunity.
Chemically, an antibody is a
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Protein
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Lipoprotein
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Lipid
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Nucleoprotein
An antibody, also known as an immunoglobulin is a large, Y-shaped protein which is produced mainly by plasma cells and it is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibodies are secreted by B lymphocytes of the adaptive immune system, mostly by differentiated B cells called plasma cells. Hence, chemically, an antibody is a protein.
Lysis of foreign cells is mediated through
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IgM only
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IgA only
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IgM and IgG
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IgD and IgE
- Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. IgM can bind to complement component and activate the classical pathway, leading to opsonization of antigens and cytolysis (lysis of foreign cells).
- IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Coating of IgG on pathogen surfaces (known as opsonization) allows their recognition and ingestion by phagocytic immune cells leading to the lysis of foreign cells.
Antibodies are formed by
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T-cells
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Monocytes
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Phagocytes
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B-cells
Antibody are produced by B-lymphocytes. The plasma cell /plasma B cells/effector B cell are white blood cells that secrete large volumes of antibodies. Plasma cell originates in the bone marrow.B cell differentiate into a plasma cell that produces antibody molecules. These are transported by the blood plasma and the lymphatic system. Once these are released into the blood and lymph, these antibody molecules bind to the target antigen and initiate its neutralization or destruction.
Antibodies are complex
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Lipoproteins
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Steroids
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Prostaglandins
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Glycoproteins
Immunoglobulin also known as antibodies are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses and help in their destruction.The antibody immune response is highly complex and exceedingly specific. Hence, antibodies are complex glycoproteins.
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Structural
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Transport
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Immunoglobulin
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Enzymatic
An antibody which belongs to the class of immunoglobulin is a large, Y-shaped protein which is produced mainly by plasma cells and it is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibodies are secreted by B lymphocytes of the adaptive immune system, mostly by differentiated B cells called plasma cells.
Immunoglobulins (antibodies) are basically
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Lipoproteins
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Phospholipids
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Glycoproteins
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Nucleoproteins
Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognising and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction. So, the correct option is 'Glycoproteins'
Protein released by the host cell in response to attack by a virus is known as
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Antibody
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Antigen
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Interferon
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Immunoglobulin
Antibodies (also called immunoglobulins) are large proteins. They are found in the blood or other body fluids of vertebrates. Antibodies are the key element in the adaptive immune system. The antibody recognizes a unique part of the foreign target called an antigen. It is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibody is produced by plasma cells. Antibodies can occur in two physical forms, a soluble form that is secreted from the cell to be free in the blood plasma, and a membrane-bound form that is attached to the surface of a B cell and is referred to as the B-cell receptor (BCR).
Allergens are
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Infectious and increased secretion of IgE
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Non- infectious and increased secretions of IgE
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Infectious and increased secretion of IgG
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Non- infectious and increased secretion of IgM
Body's defence system produces antibiotics.
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True
-
False
- Body's defence system produces antibodies.
- Antibodies are produced when an allergen or a foreign substance enters the human body by the immune system.
- It protects the body from unwanted foreign particles which enter the body.
- So, the correct answer is 'False'.
Which statement is correct?
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Antibodies are formed by mast cells
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B-lymphocytes are matured in thymus
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Histamine acts as inflamatory mediator
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CMI is mediated by B-lymphocytes
Mast cells are coated with IgE, which is produced by plasma cells (the antibody-producing cells of the immune system). IgE antibodies are typically specific to one particular antigen. In allergic reactions, mast cells remain inactive until an allergen binds to IgE already coated upon the cell.
How many classes of immunoglobin are there in humans?
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$3$
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$4$
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$5$
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$6$
................ is associated with allergic reactions
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IgE
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IgG
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IgA
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IgM
Antibodies are the immunoglobulins which are produced in response to the antigen. The immunoglobulin E antibodies or IgE binds to an allergen and trigger the release of inflammatory chemicals such as histamine.
Therefore, the correct answer is option A.
Antibody is formed by _____________.
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Protein
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Carbohydrate
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Nucleic acid
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Lipid
Select the correct statement with respect to diseases and immunisation.
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If due to some reason B and T-Lymphocytes are damaged, the body will not produce antibodies against a pathogen.
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Injection of dead or inactivated pathogens causes passive immunity.
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Certain protozoans have been used to mass produce hepatitis B vaccine.
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Injection of snake antivenom against snake bite is an example of active immunisation.
Clone of B-cells is called as plasma cells which produce antibodies. Helper T-cells secrete IL-2 (interleukin-2) which stimulate B cells to produce antibodies. For example iInjection of snake antivenom against snake bite that provides artificially acquired passive immunity. Thus, the correct answer is option A.
A substance produced by the host in response to an infection or foreign structure is
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Antigen
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Toxin
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Hormone
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Antibody
An antibody is a type of proteinaceous substance produced by the body's immune system when it detects harmful substances called antigens. Examples of antigens include microorganisms (bacteria, fungi, parasites and viruses) and chemicals. Each type of antibody is unique and defends the body against one specific type of antigen.
Antibodies are secreted by
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T-lymphocytes
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B-lymphocytes
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Both A and B
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Natural killer cell
An antibody or immunoglobulin is a proteinaceous compound produced mainly by differentiated plasma cells i.e., B lymphocytes. It is used by the immune system to identify and neutralize pathogens such as bacteria and viruses. Thus, the correct answer is option B.
Shape of antibody is
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Y shaped
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S shaped
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T shaped
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R shaped
- Antibodies are the Y-shaped proteinaceous compound. Each is made up of 2 heavy chains and 2 light chains.
- An antibody is made up of a variable region and a constant region, and the region that changes to various structures depending on differences in antigens is called the variable region, and the region that has a constant structure is called the constant region.
Hence, option A is correct.
A person who has been infected with a virus in the past can be determined by the presence of
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Antigens
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Antibodies
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Macrophages
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Pathogens
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Natural killer cells
The encounter of B cell with a specific antigen activates its clonal expansion which in turn gives rise to plasma cell and memory cells. Memory cells are the B cells (antibodies) responsible for long-term immunity and confirm the previous encounter of a person with the specific virus. Antigens are foreign substances that induce the immune system to produce antibodies. Disease-causing organisms are called as pathogens. Natural killer cells and macrophages are components of immune system. So, the correct answer is option D.
Antibodies in are complex
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Prostaglandins
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Glycoproteins
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Lipoproteins
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Steroids
An antibody is a protein which is produced in response to the antigen by the plasma cells. Antibodies are $\gamma$-globulin proteins that have sugar groups attached to amino acid chains. They can be classified as glycoproteins. These are y-shaped. So, the correct answer is option B.
The cells that actually release the antibodies are
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Helper T-cells
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Cytotoxic T-cells
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Plasma cells
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Memory cells
Plasma cells, also known as plasma B cells or plasmocytes are white blood cells that secrete large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Plasma cells are originated in the bone marrow, B cells differentiate into plasma cells that produce antibody molecules. Once released into the blood and lymph, these antibody molecules bind to the target antigen (foreign substance) and initiate its neutralization or destruction.
Lysis of foreign cells is mediated through
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IgM and IgG
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IgG and IgA
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IgA and IgD
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IgD and IgE
- Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates.
- IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen.
- IgM can bind to complement component and activate the classical pathway, leading to opsonization of antigens and cytolysis (lysis of foreign cells).
- IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells.
- Coating of IgG on pathogen surfaces (known as opsonization) allows their recognition and ingestion by phagocytic immune cells leading to the lysis of foreign cells.
B-cells produce antibodies in response to instruction received from
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Killer T-cells
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Suppressor T-cells
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Mast cells
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Helper T-cells
B cells, also known as B lymphocytes are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system by secreting antibodies. B-cells bind to an antigen, receive help from a cognate helper T cell and differentiate into a plasma cell that secretes large amounts of antibodies.
Number of antibodies produced per day during an infection can be
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2 trillion
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20 trillion
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200 trillion
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2000 trillion
Antibodies that function in innate immunity are
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IgM
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IgE
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IgA
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IgD
Antibody formation and immunity production by globulin protein is found in
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Haemoglobin of RBC's
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Blood platelets
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Plasma
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Cytoplasm of RBC's
An antibody is produced by plasma cell. This plasma cell /plasma B cells/effector B cell are white blood cells that secrete large volumes of antibodies. Plasma cell originates in the bone marrow. B cell differentiate into a plasma cell that produces antibody molecules. These are transported by the blood plasma and the lymphatic system. Once these are released into the blood and lymph, these antibody molecules bind to the target antigen and initiate its neutralization or destruction.
Immunoglobulin that increases in number during allergy is
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IgA
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IgE
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IgG
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IgM
Immunoglobulin E (IgE) is a type of antibody that has been found only in mammals. IgE is synthesised by plasma cells. IgE has an essential role in type I hypersensitivity (allergy) which includes allergic diseases, such as allergic asthma, sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis.
Antibody
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Induces formation of antigen
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Helps in the production of WBC
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Is formed by WBC
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None of the above
An antibody, also known as an immunoglobulin is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibodies are secreted by B lymphocytes of the adaptive immune system, mostly by differentiated B cells called plasma cells. Lymphocyte is a type of WBC. Hence, Antibody is formed by WBC.
Gamma-globulins are synthesised in
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Lymph and lymph nodes
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Liver
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Bone marrow
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Kidney
Globulins are immune molecules that are produced by the immune system in response to the invasion of the body of agents that are perceived by the system as being foreign. Gamma globulins belong to the class of globulins. Most significant globulins are immunoglobulins. Gamma globulins are synthesized in cells of the immune system known as lymphocytes, lymph nodes, lymph and plasma cells.
Immunoglobin found in serum (of new born) is
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IgG
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IgA
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IgM
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IgN
Immunoglobulin G (IgG) is a type of antibody., representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. The primary immunoglobulin of the newborn is the maternal IgG as this is the only immunoglobulin to cross the placental barrier. Hence, IgG is the immunoglobulin which is found in the serum of newborn babies.
Binding of antigen to antibody is through
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Electrostatic intereactions
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Covalent bonds
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Disulphide bridges
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Amide formation
Antibodies bind antigens through weak chemical interactions, and bonding is essentially non-covalent. Electrostatic interactions, hydrogen bonds, van der Waals forces, and hydrophobic interactions are all known to be involved depending on the interaction sites.
Resistance against disease is provided by
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Antigens
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Immunoglobulins
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Histamine
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HLA proteins
An antibody, also known as an immunoglobulin (Ig) is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibodies or immunoglobulins provides resistance against disease by neutralising antigens which are responsible for the disease. Antibodies are secreted by B-lymphocytes, mostly by differentiated B cells called plasma cells.
Which immunoglobin is the largest in size?
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IgA
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IgD
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IgE
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IgM
Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates. IgM is the largest antibody, and it is the first antibody to appear in the response to initial exposure to an antigen. Spleen and plasma cells are the major sites of specific IgM production. IgM antibodies do not pass across the human placenta.
Antibodies are produced by
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Histocytes
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Mast cells
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Plasma cells
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Fibroblasts
An antibody, also known as an immunoglobulin is a large, Y-shaped protein which is produced mainly by plasma cells and it is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. Antibodies are secreted by B lymphocytes of the adaptive immune system, mostly by differentiated B cells called plasma cells.
Which one secretes antibodies?
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Neutrophil
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Eosinophil
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Lymphocytes
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Monocyte
Antibodies are produced by specialized white blood cells called B lymphocytes/ B-cells. When an antigen binds to the B-cell surface, it stimulates the B cell to divide and mature into a group of identical cells called a clone. The mature B cells,called plasma cells, secrete millions of antibodies into the bloodstream and lymphatic system. Hence antibodies are secreted from lymphocytes.
Which one provides immunity to digestive tract against antigens?
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IgG
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IgE
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IgA
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IgD
Immunoglobulin A is an antibody that plays a crucial role in the immune function of mucous membranes. The amount of IgA produced in association with mucosal membranes is greater than all other types of antibody combined. It is the main immunoglobulin found in mucous secretions, including tears, saliva, sweat, colostrum and secretions from the genitourinary tract, gastrointestinal tract, prostate and respiratory epithelium. It is also found in small amounts in the blood. Hence it provides immunity to the digestive tract as it is made up of a mucous membrane.
The function of IgE is
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Mediate in allergic response
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Activation of B-cells
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Protection from inhaled and ingested pathogen
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Stimulation of complement system, passive immunity to foetus
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present on lymphocytes surface as receptors
Immunoglobulin E (IgE) is a type of antibody that has only been found in mammals. IgE is synthesised by plasma cells. It plays an essential role in type I hypersensitivity, which manifests in various allergic diseases, such as allergic asthma, rhinitis etc. It also plays a pivotal role in responses to allergens, such as anaphylactic drugs, bee stings, and antigen preparations used in desensitization immunotherapy.
Antibodies are synthesised by
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B-lymphocyes
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Helper T-cells
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T-lymphocytes
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Memory cells
An antibody is produced by plasma cell. The B-Lymphocytes are white blood cells that secrete large volumes of antibodies. Plasma cell originates in the bone marrow. B cell differentiate into a plasma cell that produces antibody molecules. These are transported by the blood plasma and the lymphatic system. Once these are released into the blood and lymph, these antibody molecules bind to the target antigen and initiate its neutralization or destruction.
Antibody formed of five immunoglobin units /pentamer is
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IgG
-
IgM
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IgA
-
IgD
Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates. IgM is the largest antibody and it is the first antibody to appear in the response to initial exposure to an antigen. On the basis of its sedimentation velocity and appearance in electron micrographs, it was inferred that IgM is mostly a pentamer i.e., a polymer composed of five monomers.
Which of the following is involved in allergic reaction?
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IgA and mast cells
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IgG and basophils
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IgE and mast cells
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IgG and mast cells
- In response to an allergy, IgE is secreted and circulates in the blood and binds to an IgE-specific receptor on the surface of other kinds of immune cells called mast cells and basophils, which are both involved in the acute inflammatory response.
- The IgE-coated cells, at this stage, are sensitized to the allergen.
- Hence, IgG and mast cells are involved in an allergic reaction.
- So, the correct answer is 'IgG and mast cells'.
Immunoglobulin abundant in colostrum is
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IgG
-
IgA
-
IgM
-
IgE
-
IgD
- Immunoglobulin A (IgA) is an antibody that plays a crucial role in the immune function of mucous membranes.
- Colostrum is a milky fluid that comes from the breasts of humans, cows, and other mammals the first few days after giving birth before true milk appears.
- Immunoglobulin abundant in colostrum is IgA in the form of secretory IgA or sIgA. Much of these are produced by plasma cells in the mammary tissue.
- So, the correct answer is 'IgA'.
Which antibody is first to be released in to blood following an infection
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IgD
-
IgG
-
IgM
-
IgA
Immunoglobulin M (IgM) is one of several forms of the antibody that are produced by vertebrates. IgM is the largest antibody and it is the first antibody to appear in the response to initial exposure to an antigen in the blood. IgM antibodies appear early in the course of an infection and usually reappear to a lesser extent after further exposure to the same antigen. IgM antibodies do not pass across the human placenta.
In our body, antibodies are formed against pathogens in
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liver by RBCs
-
blood by platelets
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thymus by lymphocytes
-
brain by macrophages
The thymus gland, despite containing glandular tissue and producing several hormones, is much more closely associated with the immune system than with the endocrine system. The thymus serves a vital role in the training and development of T-lymphocytes or T cells, an extremely important type of white blood cell. T cells defend the body from potentially deadly pathogens such as bacteria, viruses, and fungi. The function of the thymus is to receive immature T cells that are produced in the red bone marrow and train them into functional, mature T cells that attack only foreign cells. T cells first reside within the cortex of the thymus where they come in contact with epithelial cells presenting various antigens. The immature T cells that respond to the antigens corresponding to foreign cells are selected to survive, mature, and migrate to the medulla while the rest die via apoptosis and are cleaned up by macrophages.
The classical pathway of complement is activated by?
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Only antibody
-
Only antigen
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Ag-antibody complex
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None of these
Cells which actually release the antibodies are
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Helper T-cells
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Cytotoxic T-cells
-
Suppressor T-cells
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Plasma cells
Antibodies are secreted by cells of the adaptive immune system; B cells, which are formed by the differentiation of the plasma cells. B lymphocytes have antibodies attached to them. Once they detect an antigen, they transform into plasma cells and secrete antibodies until the immune response is over.
Monoclonal antibodies are
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Single parent type that attack many antigens
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Single parent type and attack specific antigen
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Various parent type and attack many antigens
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Various parent type and attack single antigen
If the identical antibodies are produced by the single clone of cells such antibodies are called as monoclonal antibodies. They are clones or single type but they are target specific. Each monoclonal antibody recognizes one particular protein (antigen). They work in different ways depending on the protein they are targeting. Thus, the correct answer is option B.
Antibodies combine with antigens
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at variable regions
-
at constant regions
-
only if macrophages are present
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both (a) and (C)
In the blood, the antigens are specifically and with high affinity bound by antibodies to form an antigen-antibody complex. The antigenic determinant or epitope is recognized by the paratope of an antibody, situated at the variable region of the polypeptide chain.
Which one of the following statements is correct with respect to immunity?
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Preformed antibodies need to be injected to treat the bite by a viper snake
-
The antibodies against small pox pathogen are produced by T-lymphocytes
-
Antibodies are protein molecules, each of which has four light chains
-
Rejection of a kidney graft is the function of B-lymphocytes
A. Anti-snake venom is made by collecting venom from the snake and injecting small amounts of it usually into a horse. The antibodies that form in the horse blood are then collected and used to treat a snake bite case by injecting directly to the affected person.
B. Antibodies against smallpox are produced by B-lymphocytes.
C. Antibodies contain 2 light chains and 2 heavy chains.
D. Rejection of a kidney graft is a function of T-lymphocytes.
What are antibodies chemically composed of?
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Lipid
-
Nucleoprotein
-
Carbohydrate
-
Protein
Antibodies are nothing but proteins. There are 5 types of antibodies, IgG, IgM, IgA, IgE, IgD. They are produced by B lymphocytes.
Condition in which immune system fails is
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Allergy
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AIDS
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Tetanus
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Typhoid
Antibodies are produced in
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Human body
-
Industries
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Pharmacy
-
None of the above
Antibodies are also known as
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Immunoglobulin
-
Anti-toxin
-
Immunogen
-
None of the above
Immunoglobulins are the proteinaceous substances produced by the immune cells (B cell) that function as antibodies. The terms antibody and immunoglobulin are often used interchangeably. Thus, the correct answer is option A.
Antibodies recognize
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Antigens
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Germs
-
Diseases
-
None of the above
Antibodies are small proteinaceous substance made by the immune cells. Antibodies attach to proteins and other chemicals in the body, which they recognise to be not normally found in the body ('foreign'). The foreign proteins and chemicals that antibodies attach to are called as antigens. Thus, the correct answer is option A.
Antibodies are formed by
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Plasma cells
-
Histiocytes
-
Mast cells
-
None of the above
- Antibodies are produced by specialized white blood cells called B lymphocytes (or B cells).
- B lymphocytes are activated on their encounter with foreign agents. These foreign particles act as foreign markers.
- The B-cells immediately differentiate into plasma cells and memory cells. The plasma cells produce antibodies specific to that foreign particle or so-called antigen.
- These antibodies attach to the surface of the antigen/foreign agent.
- These antibodies detect any antigen in the body and destroy it.
- Hence Antibodies are formed by Plasma cells.
- So, the correct answer is 'Plasma cells'.
Antibody which mediates allergic response is
-
IgA
-
IgD
-
IgE
-
IgM
Immunoglobulin E (IgE) is a type of antibody that has been found only in mammals. IgE is synthesised by plasma cells. IgE also has an essential role in type I hypersensitivity which includes allergic diseases, such as allergic asthma, sinusitis, allergic rhinitis, food allergies, and specific types of chronic urticaria and atopic dermatitis.
Antibody production is carried out by
-
Monocytes
-
leuococytes
-
Lymphocytes
-
Erythrocytes
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system. Lymphocytes include natural killer cells (which function in cell-mediated, cytotoxic innate immunity), T cells (for cell-mediated, cytotoxic adaptive immunity), and B cells (for humoral, antibody-driven adaptive immunity). They are the main type of cell found in lymph. Lymphocytes are involved in the activation of the immune system. Hence, B-lymphocytes are involved in the production of an antibody.