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Parathyroid gland - class-XI

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Tetany (irregular muscle contraction) and osteoporosis are caused due to the deficiency of

  1. Cortisone

  2. Estrogen

  3. Insulin

  4. Parathormone


Correct Option: D
Explanation:

Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid hormone. This can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany (involuntary muscle contraction).

Which of the following is correctly matched?

  1. Thyroxine - tetanus

  2. Insulin - diabetes insipidus

  3. Adrenaline - hepatitis

  4. Parathyroid - tetany


Correct Option: D
Explanation:

Tetany is an abnormal condition characterized by periodic painful muscular spasms and tremors, caused by faulty calcium metabolism and associated with diminished function of the parathyroid glands.

Parathormone influences calcium absorption in the small intestine by regulating the metabolism of

  1. Vitamin C

  2. Vitamin D

  3. Vitamin $B _{6}$

  4. Enterogasterone


Correct Option: B
Explanation:

Vitamin D increases blood concentrations of calcium. It is generated through the activity of parathyroid hormone within the kidney. The most important effect of vitamin D is to facilitate absorption of calcium from the small intestine. Along with thyroid hormone, vitamin D also enhances fluxes of calcium out of bone.

Parathormone regulates

  1. Blood calcium level

  2. Blood calcium and phosphate level

  3. Body temperature

  4. None of the above


Correct Option: B
Explanation:

Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands. It acts to increase the concentration of calcium ($Ca^{2+}$) in the blood. Parathormone also inhibits the reabsorption of phosphate by the kidney tubules, thereby decreasing serum phosphate concentrations. This potentiates the ability of parathormone to increase serum calcium concentrations because fewer insoluble calcium-phosphate complexes are formed when serum phosphate concentrations are low.

The hormones responsible for regulation of calcium and phosphorous metabolism is secreted by

  1. Pancreas

  2. Thyroid

  3. Thymus

  4. Parathyroid


Correct Option: D
Explanation:

Parathormone of parathyroid gland reduces the blood phosphate level while increases the blood calcium level. Antagonistic functions of insulin and glucagon hormones of pancreas maintain the homeostasis of blood glucose level. Thyroid hormones regulate the metabolic rate of the body. Thymus hormone serves in the differentiation of lymphocytes present inside the lobules. Thus, the correct answer is D.

Parathormone deficiency in man causes

  1. Hypercalcemia

  2. Hypocalcaemia

  3. Goitre

  4. All of the above


Correct Option: B
Explanation:

A low level of parathyroid hormone (hypoparathyroidism) can cause hypocalcemia, which results when too much calcium is lost in urine or when not enough calcium is moved from bones into the blood. 

Parathyroid hormone

  1. Is produced by the thyroid gland

  2. Is released when blood calcium levels fall

  3. Stimulates osteoblasts to lay down new bone

  4. Stimulates calcitonin release


Correct Option: B
Explanation:

Parathyroid hormone is secreted by the parathyroid glands and is the most important regulator of calcium levels in the blood and within the bones. Parathyroid hormone is mainly controlled by the negative feedback of calcium levels in the blood to the parathyroid glands. Low calcium levels in the blood stimulate parathyroid hormone secretion, whereas high calcium levels in the blood prevent the release of parathyroid hormone.

Parathormone deficiency leads to

  1. Decrease of $Ca^{+2}$ level in blood

  2. Increase of $Ca^{+2}$ level in blood

  3. Osteoporosis

  4. None of the above


Correct Option: A
Explanation:

Hypoparathyroidism is the state of decreased secretion or activity of parathyroid hormone (PTH). This leads to decreased blood levels of calcium (hypocalcemia) and increased levels of blood phosphorus (hyperphosphatemia).

Parathyroid hormone is a 

  1. Peptide

  2. Carbohydrate

  3. Lipid

  4. Steroid


Correct Option: A
Explanation:

Parathyroid hormone (PTH) or parathormone is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium in the blood.

Parathormone is secreted during 

  1. Increased blood calcium level

  2. Decreased blood calcium level

  3. Increased blood sugar level

  4. Decreased blood sugar level


Correct Option: B
Explanation:

Parathyroid hormone is mainly controlled by the negative feedback of calcium levels in the blood to the parathyroid glands. Low calcium levels in the blood stimulate the parathyroid hormone secretion, whereas high calcium levels in the blood prevent the release of parathyroid hormone. 

The pituitary gland by virtue of its tropic hormones controls the secretory activity of other endocrine glands. Which one of the following endocrine glands can function independently of the pituitary gland?

  1. Thyroid

  2. Gonads

  3. Adrenal

  4. Parathyroid


Correct Option: D
Explanation:

The parathyroid glands are four tiny glands, located in the neck, each gland is about the size of a grain of rice. Parathyroid gland secretes parathormone hormone, which regulates $Ca^{++}$ and phosphate ion in the body. This gland works independently to the pituitary gland. 

The pituitary gland, on the other hand, is the major endocrine gland, a pea-sized body attached to the base of the brain that is important in controlling growth and development and the functioning of the other endocrine glands, which includes thyroid, gonads and adrenals etc. 
Therefore, the correct answer is option D.

The blood calcium level falls too low because

  1. The thyroid gland releases calcitonin, which binds to bone cells

  2. The parathyroid glands release PTH, which binds to kidney cells

  3. The thyroid gland releases thyroid hormone, which binds to small intestine cells

  4. The pancreas releases glucagon, which binds to liver cells

  5. The pituitary gland releases growth hormone, which binds to bone cells


Correct Option: A
Explanation:

Parathormone of parathyroid gland increases the blood calcium level by binding to receptors present on DCT of the nephron to stimulate conditional reabsorption of calcium. Thyroid hormone does not have any specific target cell and stimulate metabolic rate by all cells. Glucagon regulates blood glucose level while growth hormone stimulate overall growth and development. Calcitonin hormone stimulates a temporary reduction in number and activity of osteoclasts (bone cells) and thereby reducing the blood calcium level. Thus, the correct answer is option A.

Parathyroid maintains the calcium level in the blood by action on which of the following organs?

  1. Bone

  2. Kidney

  3. Intestine

  4. All of the above


Correct Option: D
Explanation:
  • Parathyroid hormone regulates calcium levels in the blood, largely by increasing the levels when they are too low. 
  • It does this through its actions on the kidneys, bones and intestine. 
  • Bone parathyroid hormone stimulates the release of calcium from large calcium stores in the bones into the bloodstream. Hence, Parathyroid maintains the calcium level in the blood by action on Bone, Kidney and Intestine.
  • So, the correct answer is 'All of the above'.

Which endocrine gland becomes inactive in old age?

  1. Adrenal

  2. Pineal

  3. Thymus

  4. Pituitary


Correct Option: C
Explanation:

Thymus is well developed in new born child and grows upto the age of puberty after that it starts shrinking and almost disappears in old age.

Parathormone influences calcium absorption in small intestine by regulating metabolism of 

  1. Vitamin C

  2. Vitamin D

  3. Vitamin B

  4. Enterogastrone


Correct Option: B
Explanation:
Parathormone is secreted from the parathyroid hormone and increases blood calcium level by increasing the reabsorption of calcium from the bones. Parathormone increases calcium absorption in small intestine by regulating metabolism of vitamin D because it stimulates osteoclasts. These are the cells that cause breakdown by dissolution of calcium from bone and thus, concentration of calcium is increased in blood.
So, the correct answer is 'Vitamin D'.

Hormone responsible for regulation of calcium and phosphorus homeostasis is secreted by

  1. Pituitary

  2. Parathyroids

  3. Thymus

  4. Pancreas


Correct Option: B
Explanation:

The parathyroid glands are small endocrine glands in the neck that produce parathyroid hormone. Humans have four parathyroid glands, which are usually located behind the thyroid gland and in rare cases, within the thyroid gland or in the chest. Parathyroid glands control the amount of calcium in the blood and within the bones.

Which of the following statements is correct for 'parathormone'?

  1. It increases blood calcium level and decreases calcium store of the bone

  2. It decreases blood calcium level and increased calcium store of the bone

  3. It increases blood glucose level and decreases calcium store of the bone

  4. It decreases blood glucose level and increases calcium store of the bone


Correct Option: A

In which of the following options, hormone is not matching with its source and function?

  1. Hormone- Glucocorticoids, Source-Adrenal cortex, Function-Produces anti-inflammatory reactions

  2. Hormone-Vasopressin, Source-Posterior pituitary, Function-Stimulates resorption of water and electrolytes

  3. Hormone-Parathyroid hormone, Source-thyroid, Function-Decreases the blood $Ca^{2+}$ level

  4. Hormone-Melatonin, Source-Pineal gland, Function-Maintains sleep-wake cycle


Correct Option: C
Explanation:

Hormone released by the parathyroid gland is parathyroid hormone also called parathormone or parathyrin, this hormone regulates the Ca$^{+2}$ concentration in the serum by acting upon bone, kidney and intestine.

So, the correct answer is 'Hormone-Parathyroid hormone, Source-thyroid, Function-Decreases the blood Ca$^{+2}$ level'

The blood calcium level is lowered by the deficiency of.

  1. Thyroxine

  2. Calcitonin

  3. Parathormone

  4. Both (a) and (b)


Correct Option: C
Explanation:

Parathormone secreted by parathyroid gland regulates the level of calcium in the blood. It stimulates the release of calcium from the bones into the blood, increases calcium absorption from the intestine into the blood and it also increases calcium reabsorption from the nephrons into the blood. Therefore, its deficiency leads to low blood calcium level.

Parathormone influences calcium absorption in the small intestine by regulating the metabolism of 

  1. Vitamin C

  2. Vitamin D

  3. Vitamin ${ B } _{ 6 }$

  4. Enterogasterone


Correct Option: B
Explanation:

The kidney processes Vitamin D into calcitriol, the active form that is most effective in assisting intestinal absorption. This process is stimulated by parathyroid hormone. Vitamin D is an important co-factor in the intestinal absorption of calcium, as it increases the number of calcium binding proteins, involved in calcium absorption through the apical membrane of enterocytes in the small intestine.

The pituitary gland by virtue of its tropic hormones controls the secretory activity of other endocrine glands. Which one of the following endocrine glands can function independent of the pituitary gland?

  1. Adrenals

  2. Gonads

  3. Thyroid

  4. Parathyroid


Correct Option: D
Explanation:

Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods that produce parathyroid hormone. Humans usually have four parathyroid glands, variably located on the back of the thyroid gland. Parathyroid hormone and calcitonin (one of the hormones made by the thyroid gland) have key roles in regulating the amount of calcium in the blood and within the bones. The major function of the parathyroid glands is to maintain the body's calcium and phosphate levels within a very narrow range, so that the nervous and muscular systems can function properly. The parathyroid glands do this by secreting parathyroid hormone.

So the correct option is 'parathyroid'.

Name the two hormones that regulates blood calcium levels in the body

  1. Insulin and glucagon

  2. Thyroxine and estrogen

  3. Thyrocalcitonin and parathyroid hormone

  4. Prolactin and oxytocin


Correct Option: C
Explanation:

Thyrocalcitonin (TCT) is secreted when calcium level in blood is high. It then lowers the levels by suppressing  release of calcium ions from bones. Whereas parathyroid hormone increases the blood calcium level by increasing calcium absorption from intestine and mobilising calcium from bones to blood.

Which of the following activities is disturbed, if parathyroid gland degenerates?

  1. Growth

  2. Sodium concentration

  3. Potassium concentration

  4. Calcium concentration


Correct Option: D
Explanation:

Parathyroid gland secretes hormone called parathormone (PTH). This hormone regulates calcium and phosphate balance between blood and other tissue. so, if parathyroid gland degenerates calcium concentration will be adversely affected.

so, the correct answer is option D.

Hyper secreation of Parathyroid hormone result in ___________________.

  1. Stronger bones due to increased incorporation of calciuim in them.

  2. Deposition of calcium in various skeletal structure.

  3. No effect on the constitution of bones

  4. Weaker bones due to increased removal of calcium from them


Correct Option: B
Explanation:

 A parathyroid gland tumor can prompt hypersecretion of PTH. This can raise blood calcium levels so excessively that calcium deposits begin to accumulate throughout the body, including in the kidney tubules. When calcium levels in your blood fall too low, your parathyroid glands secrete enough PTH to restore the balance but sometimes these glands produce an excess amount of hormone, leading to abnormally high levels of calcium (hypercalcemia) and low levels of phosphorus in your blood.

So, the correct answer is 'Deposition of calcium in various skeletal structures.'

Philips Collip discovered which of the following hormones?

  1. Parathyroid hormone

  2. Thyroxine

  3. ADH

  4. Oxytocin


Correct Option: A
Explanation:

Bovine parathormone is a large polypeptide having 84 amino-acids. It was discovered and purified by Philips Collip in 1925. 

All are the function of PTH except ______________________.

  1. PTH simulates bone reabsorption /dilution /demineralization

  2. PTH retards osteoclastic action

  3. PTH increases $Ca^{+2}$ abosorption from the digestive tube

  4. PTH stimulates reabsorption of $Ca^{+2}$ by the renal tubules


Correct Option: A
Explanation:
The hormone released by the parathyroid glands is called the parathyroid hormone (PTH). It is also called parathyrin. This hormone is involved in the formation or mineralization of bones. It is released when the levels of calcium ions in the blood serum decreases.
Hence, the correct answer is 'PTH simulates bone reabsorption /dilution /demineralization'.

Increase in bleeding time and delay in blood coagulation is due to the deficiency of which hormone?

  1. Thyroxine

  2. Adrenaline

  3. Noradrenaline

  4. Parathormone


Correct Option: D
Explanation:
  • In humans, four parathyroid glands are present on the back side of the thyroid gland, one pair each in the two lobes of the thyroid gland.
  • The parathyroid glands secrete a peptide hormone called parathyroid hormone (PTH) or parathormone.
  • Parathormone increases the $Ca^{2+}$ levels in the blood.
  • Increase in bleeding time and delay in blood coagulation is due to the deficiency of parathormone because its deficiency causes a decrease in blood calcium levels and calcium ion is essential for blood coagulation.
  • So, the correct answer is 'Parathormone'.

Which of the following reasons states that parathyroid is hormone is a hypercalcemic hormone?

  1. PTH also stimulates reabsorption of Ca2+ by the renal
    tubules

  2. PTH increases Ca2+ absorption from the digested food

  3. PTH control the metabolism of carbohydrates,
    proteins and fats

  4. Both A and B


Correct Option: D
Explanation:

In humans, four parathyroid glands are present on the back side of the thyroid gland, one pair each in the two lobes of the thyroid gland. They secrete a peptide hormone called parathyroid hormone (PTH).
PTH increases Ca2+ absorption from the digested food. it also stimulates reabsorption of Ca2+ by the renal tubules.PTH acts on bones and stimulates the process of bone resorption (dissolution/demineralization). 
 Hence PTH is a hypercalcemic hormone, i.e., it increases the blood Ca2+ levels. Along with TCT(Thyrocalcitonin), it plays a significant role in calcium balance in the body

So, the correct option is 'Both A and B'.

Parathyroid hormone is: 

  1. Protein

  2. Carboh

  3. Lipid

  4. Steroid


Correct Option: A
Explanation:

  • parathyroid hormone (PTH) is a protein in nature composed of 84 amino acids. 
  • parathyroid glands make more or less parathyroid hormone (PTH) in response to the level of calcium in the blood. 
  • When the calcium in our blood goes too low, the parathyroid glands make more PTH. so, option A is correct answer .
  • Which of the following is not associated with parathyroid hormone (PTH)?

    1. It promotes release of $Ca^{2+}$ from bone matrix into the blood

    2. It stimulates kidney to release calcitriol

    3. More PTH is released when blood calcium level rises

    4. Hypoparathyroidism result in parathyroid terany


    Correct Option: B
    Explanation:
    • Parathyroid hormone- It is also known as parathormone or parathyrin.
    • It is a secreted by the parathyroid glands.
    • Its main function includes bone remodelling by releasing more PTH when the calcium in our blood goes too low, which increases the blood calcium level that is released from bones.
    • This hormone stimulates calcitriol production in the kidney as it synthesises 1-α hydroxylase and also maintains calcium levels by increasing calcium absorption in the gastrointestinal tract 
    • Hypoparathyroidism- leads to low levels of calcium in the blood which causes cramps and twitches in muscles or tetany.
    • So, the correct answer is 'More PTH is released when blood calcium level rises'.

    Which of the following hormones coordinate with each other to maintain ideal blood $Ca$ level?

    1. Thyrocalcitonin and glucagon

    2. Parathyroid hormone and cortisol

    3. Thyrocalcitonin and Thyroxin

    4. Thyrocalcitonin and Parathyroid hormone


    Correct Option: D
    Explanation:
    • In addition, tetraiodothyronine or thyroxine (T4) and triiodothyronine (T3) Thyroid gland also secretes a protein hormone called thyrocalcitonin. 
    • Thyrocalcitonin(TCT) lowers blood calcium levels. It counters the actions of parathyroid hormone which increases the blood calcium level.
    • The parathyroid glands monitor the calcium in the blood 24 hours per day. The four parathyroid glands make more or less parathyroid hormone (PTH) in response to the level of calcium in the blood. When the calcium in our blood goes too low, the parathyroid glands make more PTH in order to increase the blood calcium levels.
    • Hence Thyrocalcitonin and Parathyroid hormones coordinate with each other to maintain ideal blood Ca level.
    • So, the correct answer is 'Thyrocalcitonin and Parathyroid hormone'.

    Hyposecretion of parathyroid hormone affects blood

    1. Iron concentration

    2. Calcium concentration

    3. Potassium concentration

    4. Sodium concentration


    Correct Option: B
    Explanation:
    Parathyroid gland is present in the form of four small pouches which are embedded in the posterior surface of lobes of thyroid gland. This gland secretes parathormone which increases calcium reabsorption from the bones by dissolution and demineralisation and causes mobilisation of calcium in the blood. It is a hypercalcemic hormone.
    Hence, parathyroid hormone or parathormone affects blood calcium level.
    So, the correct answer is 'Calcium concentration'.

    Blood calcium is increased by administration of 

    1. Glucagon

    2. Thyroxine

    3. Parathormone

    4. Calcitonin


    Correct Option: C
    Explanation:
    A. Glucagon is secreted from alpha cells of islets of Langerhans of pancreas. It increases blood sugar level by stimulating glycogenolysis (i.e. break down of glucose) and gluconeogenesis (synthesis of glucose).
    B. Thyroxine is secreted from thyroid gland. It stimulates the consumption of oxygen by metabolically active tissues and also increases the oxidation of glucose in tissues. 
    C. Parathormone is secreted from parathyroid gland and increases calcium reabsorption from the bones and causes mobilisation of calcium in the blood.
    D. Calcitonin is secreted from the C-cells of thyroid gland and acts on bone and kidneys to reduce blood calcium level.
    Hence, blood calcium level is increased by parathormone.
    So, the correct answer is 'Parathormone'.

    Parathormone deficiency causes

    1. Goitre

    2. Hypocalcemia

    3. Hypercalcemia

    4. All of the above


    Correct Option: B
    Explanation:
    A. Goitre is the enlargement of thyroid gland which occurs due to deficiency of iodine in the body. When the iodine levels are low, thyroid gland becomes hyper active and enlarged to compensate the deficiency of thyroid hormone in the body. The enlarged thyroid gland is visible as a swelling in the throat known as goitre.
    B. Hypocalcemia is the condition of reduced sugar levels in blood.
    C. Hypercalcemia is the condition of increased sugar levels in blood.
    Parathormone is secreted from the parathyroid hormone and increases blood calcium level by increasing the reabsorption of calcium from the bones. Hence, its deficiency will lead to decreased sugar levels in blood i.e. hypocalcemia.
    So, the correct answer is 'Hypocalcemia'.

    Gland responsible for calcium metabolism is 

    1. Thymus

    2. Thyroid

    3. Parathyroid

    4. Adrenal


    Correct Option: C
    Explanation:
    A. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
    B. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
    C. Parathyroid gland is present in the form of four small pouches which are embedded in the posterior surface of lobes of thyroid gland. This gland secretes parathormone which increases calcium reabsorption from the bones and causes mobilisation of calcium in the blood.
    D. Adrenal gland is present on upper side of kidneys and has two parts, adrenal cortex which secrete glucocorticoids, mineralocorticoids and sexocorticoids and adrenal medulla which secrete adrenaline and nor-adrenaline hormone.
    Hence, the gland responsible for calcium metabolism is parathyroid gland.
    So, the correct answer is 'Parathyroid'.

    A person is having problems with calcium and phosphorus metabolism in his body. Which one of the following glands may not be functioning properly?

    1. Pancreas

    2. Parotid

    3. Parathyroid

    4. Thyroid


    Correct Option: C
    Explanation:
     There are 4 types of parathyroid glands, two inferior and two superior, located on the posterior surface of the thyroid gland. the produce and secrete parathyroid hormone (PTH). It is also called as parathormone. PTH controls the calcium concentration in the blood. The main function is to regulate calcium absorption from the intestines and excretion of calcium by kidneys. It also helps release calcium from the bones into the bloodstream when there is dropping of calcium level in the body. The improper functioning of parathyroid may lead to problems in calcium metabolism. 
    So, the correct option is 'Parathyroid'.

    Osteoporosis is caused by

    1. Fe$^{2+}$ defeciency

    2. Na$^+$ deficiency

    3. Parathormone hyposecretion

    4. Parathormone hypersecretion


    Correct Option: D
    Explanation:
    Osteoporosis is a condition in which bone density decreases and bones become weak and brittle. It occurs due to hypersecretion of parathormone. Parathormone is secreted from the parathyroid hormone and increases blood calcium level by increasing the reabsorption of calcium from the bones. Over secretion of parathormone causes more calcium dissolution from the bones leading to decreased bone density.
    So, the correct answer is 'Parathormone hypersecretion'.

    Hormone regulating calcium and phosphorus metabolism in the body is secreted by 

    1. Thyroid

    2. Parathyroid

    3. Thymus

    4. Pancreas


    Correct Option: B
    Explanation:
    A. Thyroid gland is situated between the trachea and larynx in the neck and secretes thyroxine hormone which increases oxygen consumption by metabolically active tissues.
    B. Parathyroid gland is present in the form of four small pouches which are embedded in the posterior surface of lobes of thyroid gland. This gland secretes parathormone which increases calcium reabsorption from the bones and causes mobilisation of calcium in the blood. This hormone also regulates phosphate excretion through urine.
    C. Thymus gland is associated with the development of immune system and present on the dorsal side of heart. It secretes thymosin hormone which plays an important role in the differentiation of T-lymphocytes.
    D. Pancreas is a heterocrine gland as it acts both as endocrine and exocrine gland. It secretes insulin hormone into blood and act as endocrine gland and when it secretes digestive enzymes and juice through pancreatic duct, it acts as exocrine gland.
    Hence, hormone regulating calcium and phosphorus metabolism in the body.
    So, the correct answer is 'Parathyroid'.

    Parathormone is secreted when there is 

    1. Increased Ca$^{2+}$ level in blood

    2. Decreased blood Ca$^{2+}$ level

    3. Increased blood sugar level

    4. Decreased blood sugar level


    Correct Option: B
    Explanation:

    The parathyroid glands secrete a peptide hormone called parathyroid hormone or parathormone (PTH). The release of parathromone is regulated by the circulating levels of calcium ($Ca^{2+}$) ions in the blood. PTH plays an important role in calcium balance of the body. It maintains the calcium balance between the blood and other tissues. When the calcium level in the blood decreases, parathyroid hormone is released in order to increase the calcium level in the blood. PTH acts on bones and other skeletal structure and mobilizes the calcium ($Ca^{2+}$) from the bones into the blood. This is called bone resorption/dissolution/demineralization. The parathromone also increases the reabsorption of calcium by the renal tubules and absorption of calcium from the digested food. Hence, PTH (parathormone) is a hypercalcemic hormone that increases the blood calcium levels.

    Choose the correct answer from the alternatives given.
    Parathyroid hormone (PTH) and calcitonin (CT) control the levels of which of the following ions in blood?

    1. Calcium

    2. Sodium

    3. Potassium

    4. Chloride


    Correct Option: A
    Explanation:

    The thyroid gland secretes a protein hormone called thyrocalcitonin (TCT) which regulates the blood calcium levels. Parathyroid hormone (PTH) increases the calcium levels in the blood. It also stimulates reabsorption of calcium by the renal tubules and increases calcium absorption from the digested food.

    So the correct answer is calcium.

    Low Ca$^{2+}$ in body fluid may be the reason for 

    1. Anaemia

    2. Angina pectoris

    3. Gout

    4. Tetany


    Correct Option: D
    Explanation:
    Low calcium levels in body cause hypocalcaemia. This may cause tetany, a disorder that occurs due to deficiency of parathormone. Parathormone is secreted from the parathyroid gland and increases blood calcium level by increasing the reabsorption of calcium from the bones. When parathormone levels are low, calcium level also gets decreased and this cause muscular spasms, a symptom of tetany. The muscles contract involuntarily and this causes painful cramps.
    So, the correct answer is 'Tetany'.

    Which one of the following pairs correctly matches a hormone with a disease resulting from its deficiency : -

    1. Relaxin Gigantism

    2. Prolactin Cretinsim

    3. Parathyroid hormone Tetany

    4. Insulin Diabetes insipidus


    Correct Option: C
    Explanation:
    • Gigantism is a rare condition of accelerated growth and increased height as a result of too much growth hormone secretion during childhood or adolescence. It is almost always the result of a growth hormone-secreting pituitary tumour.
    •  Congenital hypothyroidism (under activity of the thyroid gland at birth), which results in growth retardation, developmental delay, and other abnormal features. Cretinism can be due to a deficiency of iodine in the mother's diet during pregnancy.
    • Hypoparathyroidism is decreased function of the parathyroid glands with underproduction of parathyroid hormone. This can lead to low levels of calcium in the blood, often causing cramping and twitching of muscles or tetany (involuntary muscle contraction) and several other symptoms.
    • Diabetes mellitus occurs due to insulin resistance or insulin deficiency and subsequent high blood glucose levels. Diabetes Insipidus, on the other hand, develops as a result of the stilted production of a hormone in the brain, which is released to stop the kidneys producing so much urine in order to retain water.

    So, the correct answer is 'Parathyroid hormone Tetany'.

    Increase in bleeding time and delay in blood coagulation occur due to deficiency of 

    1. Adrenaline

    2. Noradrenaline

    3. Parathormone

    4. Thyroxine


    Correct Option: C
    Explanation:
    Parathormone is secreted from the parathyroid gland and increases blood calcium level by increasing the reabsorption of calcium from the bones. A deficiency of parathormone causes deficiency of calcium in blood. Calcium plays an important role in blood coagulation as aggregation of platelets and formation of fibrin fibres at the wound site require calcium.
    So, the correct answer is 'Parathormone'.

    The condition of having excess levels of potassium in blood is called _______.

    1. Hypercholesterolemia

    2. Hyperkalemia

    3. Osteomalacia

    4. Hypernatremia


    Correct Option: B
    Explanation:
    A. Hypercholesterolemia is a condition of high cholesterol in blood.
    B. Hyperkalemia is a condition of high potassium levels in blood.
    C. Osteomalacia is a condition in which bones get softened due to deficiency of calcium or vitamin D.
    D. Hypernatremia is a condition of high sodium concentration in blood.
    So, the correct answer is 'Hyperkalemia'.

    Hypercalcemic hormone is 

    1. Thyroxine

    2. Tri-iodo-thyronine

    3. Parathormone

    4. Thyrocalcitonin


    Correct Option: C
    Explanation:

    Parathormone is a hypercalcemic hormone that increases the blood calcium levels. The parathyroid glands secrete a peptide hormone called parathyroid hormone or parathormone (PTH). The release of parathromone is regulated by the circulating levels of calcium ($Ca^{2+}$) ions in the blood. PTH plays an important role in calcium balance of the body. It maintains the calcium balance between the blood and other tissues. When the calcium level in the blood decreases, parathyroid hormone is released in order to increase the calcium level in the blood. PTH acts on bones and other skeletal structure and mobilizes the calcium ($Ca^{2+}$) from the bones into the blood. This is called bone resorption/dissolution/demineralization. The parathromone also increases the reabsorption of calcium by the renal tubules and absorption of calcium from the digested food.

    Parathormone induces 

    1. Increase in blood sugar

    2. Increase in serum calcium

    3. Decrease in serum calcium

    4. Decrease in blood sugar level.


    Correct Option: B
    Explanation:

    The parathyroid glands secrete a peptide hormone called parathyroid hormone or parathormone (PTH). The release of parathromone is regulated by the circulating levels of calcium ($Ca^{2+}$) ions in the blood. PTH plays an important role in calcium balance of the body. It maintains the calcium balance between the blood and other tissues. When the calcium level in the blood decreases, parathyroid hormone is released in order to increase the calcium level in the blood. PTH acts on bones and other skeletal structure and mobilizes the calcium ($Ca^{2+}$) from the bones into the blood. This is called bone resorption/dissolution/demineralization. The parathromone also increases the reabsorption of calcium by the renal tubules and absorption of calcium from the digested food. Hence, parathormone induces increase in serum calcium.

    Which of the following is wrong? 

    1. Sella turcica is a bony cavity where pituitary gland is located.

    2. Parathyroid hormone decreases the Ca$^{2+}$ levels in blood.

    3. Thymosins play a major role in T-cell differentiation.

    4. Insulin stimulates glycogenesis.


    Correct Option: B
    Explanation:
    A. The pituitary gland is located in a bony cavity called Sella tursica and is attached to the hypothalamus by a stalk.
    B. The parathyroid glands secrete a peptide hormone called parathyroid hormone (PTH). The secretion of PTH is regulated by the circulating levels of calcium ions. PTH increases the calcium levels in the blood.
    C. Thymosins are secreted by thymus gland. These play a major role in the differentiation of T-lymphocytes, which provide cell-mediated immunity.
    D. Insulin stimulates conversion of glucose to glycogen (glycogenesis).
    So, the correct answer is 'parathyroid hormone decreases the calcium levels in blood'.

    Choose the correct answer from the alternatives given.
    Parathyroid hormone (PTH) regulates:

    1. calcium balance between blood and tissues

    2. glucose balance between blood and tissues

    3. regulates sleep

    4. regulates temperature


    Correct Option: A
    Explanation:

    The parathyroid gland secretes a peptide hormone called parathyroid hormone (PTH). The secretion of PTH is regulated by the circulating levels of calcium ions. PTH increases the calcium levels in the blood. PTH also stimulates reabsorption of calcium by the renal tubules and increase calcium absorption from the digested food.

    So the correct answer is calcium balance between blood and tissue.

    Choose the correct answer from the alternatives given.
    Hypothyroidism in children results in:

    1. dwarfism

    2. acromegaly

    3. high blood pressure

    4. high body temperature


    Correct Option: A
    Explanation:
    GH or STH (Growth or Somatotropin Hormone) stimulates body growth, protein, fat, and carbohydrate metabolism. Hyposecretion of this hormone causes dwarfism. Hypersecretion of this hormone during the period of skeletal growth causes gigantism characterized by excessive growth of bones, with the enlargement of internal organs as well. Hypersecretion in adulthood causes acromegaly. Here the bones become abnormally thick due to ossification of periosteum and thickening of soft tissues as well. 
    So the correct answer is dwarfism.

    Who discovered the parathyroid glands while dissecting a rhinoceros?

    1. Sir Richard Owen

    2. Galen

    3. Andreas Vesalius

    4. Anders Olaf Retzius


    Correct Option: A
    Explanation:

    The parathyroid gland was first discovered in 1852 during the autopsy of an Indian rhinoceros by Sir Richard Owen.

    So, the correct option is 'Sir Richard Owen'.

    A person is having problem with calcium and phosphorus metabolism in his body. Which one of the following glands may not be functioning properly?

    1. Parotid

    2. Pancreas

    3. Adrenal cortex

    4. Parathyroid


    Correct Option: D
    Explanation:

    Parathyroid glands located behind the thyroid gland, produce a hormone called parathormone. This hormone maintains calcium and phosphorus balance in the body. Thus, if a person is having problem with calcium and phosphorus metabolism in the body, this means, his parathyroid glands are not functioning properly.

    Which of the following is the target of parathyroid hormone?

    1. Kidneys

    2. Bones

    3. Small intestine

    4. Pancreas

    5. All of the above


    Correct Option: D
    Explanation:

    Parathyroid hormone regulates the level of calcium in the blood. It does this through its actions on the kidneys, bones and intestine. When  the blood calcium level is too low, the parathyroid glands release more parathyroid hormone (PTH). This causes the bones to release more calcium into the blood, increase the absorption of more calcium through food and reduces the amount of calcium released by the kidneys into the urine. 

    Goitre can occur as a consequence of all the following except

    1. Iodine deficiency

    2. Pituitary adenoma

    3. Grave's disease

    4. Excessive intake of exogenous thyroxine


    Correct Option: D
    Explanation:
    A goitre is an enlargement of the thyroid gland. The thyroid gland is controlled by the pituitary gland. The pituitary prompts the thyroid to make its hormones including thyroxine ($T _4$) and triiodothyronine ($T _3$) by releasing thyroid-stimulating hormone (TSH). If a person's diet is low in iodine, the thyroid gland enlarges as it attempts to comply with the pituitary's demands. Another common cause is Graves disease, in which the immune system produces antibodies that act like TSH and stimulate the thyroid gland uncontrollably. The gland responds by producing an excessive amount of hormones. Thyrotropin (TSH) secreting pituitary adenomas are a rare cause of hyperthyroidism. Therefore, the correct answer is option D.

    In order to determine the effect of each substance on normal body variables, they were injected intravenously. The results are shown in table below. Assume that enough time was allowed between injections so that the substances do not interfere with one another. Based on the information in table above, which of the following is most likely substance B?

    Variable Baseline values Values after injecting substance A    Values after injecting substance B    Values after injecting substance C   Values after injecting substance D
    Serum ${ Ca }^{ ++ }$ 2.3mmol/L 2.3mmol/L 2.3mmol/L 3.0mmol/L 2.3mmol/L
    Serum ${ Na }^{ + }$ 135mmol/L 135mmol/L 135mmol/L 136mmol/L 135mmol/L
    Serum glucose 5.6mmol/L 3.3mmol/L 5.6mmol/L 7.4mmol/L 5.6mmol/L

    Based on the information in table above, which of the following is most likely substance A?

    1. Glucagon

    2. Aldosterone

    3. Calcitonin

    4. Parathyroid hormone

    5. Insulin


    Correct Option: E
    Explanation:

    Homeostasis is the process wherein normal body variables are actively regulated inside a defined environment to remain very near to constant. The regulation of  concentration of sodium ($Na^+$) and Calcium ($Ca^{++}$) ions in the blood as well as  glucose levels in blood plasma are examples of Homeostasis.
    In the human body, the concentration of blood sugar levels is regulated by the  beta cells of the pancreatic islets by secreting insulin into the blood and inhibits the secretion of glucagon into the blood. The table given in the question shows the effect of a substance on the normal body variables after an intravenous injection of the same. According to the given data,  the  injection of substance A tends to decrease the concentration of Serum glucose below the baseline value. Hence, the substance that was injected is identified as insulin.

    In order to determine the effect of each substance on normal body variables, they were injected intravenously. The results are shown in the table below. Assume that enough time was allowed between injections so that the substances do not interfere with one another.

    Variable Baseline values Values after injecting substance A Values after injecting substance B Values after injecting substance C Values after injecting substance D
    Serum ${ Ca }^{ ++ }$ 2.3mmol/L 2.3mmol/L 3.0mmoL/L 2.3mmol/L 2.3mmol/L
    Serum ${ Na }^{ + }$ 135mmol/L 135mmol/L 136mmol/L 135mmol/L 135mmol/L
    Serum glucose 5.6mmol/L 3.3mmol/L 5.6mmol/L 7.4mmol/L 5.6mmol/L

    Based on the information in Table above, which of the following is most likely substance B?

    1. Calcitonin

    2. Insulin

    3. Parathyroid hormone

    4. Glucagon

    5. Aldosterone


    Correct Option: C
    Explanation:
    Homeostasis is the process wherein  normal body variables are actively regulated inside a defined environment to remain very near to constant. The regulation of the concentration of sodium (Na+) and calcium ($Ca^{++}$) ions in the blood, as well as glucose levels in blood plasma, are examples of Homeostasis. Each of the variables is controlled by a homeostat or regulator which are energy consuming physiological mechanisms of the body. The table given in the question shows the effect of a substance on the normal body variables after an intravenous injection of the same. According to the given data, since injection of substance B tends to increase the concentration of $Ca^{++}$, it is a parathyroid hormone. 
    The plasma ionized calcium ($Ca^{++}$) concentration is very tightly controlled by a pair of homeostats- the parathyroid glands and the parafollicular cells of the thyroid gland. Parathyroid hormone is secreted by the parathyroid glands in the case of a fall in the $Ca^{++}$ levels.
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