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Contractile protein - class-XII

Description: contractile protein
Number of Questions: 49
Created by:
Tags: skeleton and movements biology animal physiology zoology musculo-skeletal system locomotion and movements locomotion and movement coordination
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The important muscle proteins that helps in the movement are 

  1. Actin and myosin

  2. Troponin

  3. Tropomyosin

  4. All of the above


Correct Option: D
Explanation:
  • Skeletal muscle fiber is made up of two types of filaments. They are thick filament (myosin) and thin filament (actin). Contraction of a muscle fiber takes place by the sliding of the thin filaments over the thick filaments.
  • Myosin (thick) filament is also a polymerized protein. Many monomeric proteins called meromyosins constitute one thick filament. 
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein troponin is distributed at regular intervals on the tropomyosin.
  • Hence, the important muscles proteins that help in the movement are actin and myosin, troponin and tropomyosin.
  • So, the correct answer is 'All of the above'.

In resting stage, binding sites for myosin on actin filaments are masked by

  1. Troponin

  2. Light meromyosin

  3. Heavy meromyosin

  4. Calcium ions


Correct Option: A
Explanation:
  • Skeletal muscle fiber is made up of two types of filaments. They are thick filament (myosin) and thin filament (actin). Contraction of a muscle fiber takes place by the sliding of the thin filaments over the thick filaments.
  • Myosin (thick) filament is also a polymerized protein. Many monomeric proteins called meromyosins constitute one thick filament. 
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length
  •  In the resting state a subunit of troponin masks the active binding sites for myosin on the actin filaments.
  • So, the correct answer is 'Troponin'.

Thick filaments in muscles are polymerised proteins of

  1. Meromyosin

  2. Actin

  3. Troponin

  4. Tropomyosin

  5. Keratin


Correct Option: A
Explanation:
  • Myofibrils are composed of two types of filaments i.e thin filament (actin) and thick filament (myosin).
  • Actin filaments are thinner as compared to the myosin filaments, hence are commonly called thin and thick filaments respectively
  • Each myosin (thick) filament is a polymerized protein. Many monomeric proteins called meromyosins constitute one thick filament (Myosin).
  • Hence thick filaments in muscles are polymerized proteins of meromyosin.
  • So, the correct answer is 'Meromyosin'.

 The thin filaments of myofibril contain  __(A)_ actin and two filaments of (B) protein along with  (C)_  protein for masking binding site for myosin. 

  1. A - 1F B - troponin C - Tropomyosin

  2. A - 1F B - tropomyosin C - troponin

  3. A - 2F B - troponin C - tropomyosin

  4. A - 2F B - tropomyosin C - troponin


Correct Option: A
Explanation:

Thin filaments of myofibril contain one filament of actin and two filaments of troponin, along with tropomyosin protein.

So, the correct option is 'A - 1F B - troponin C - Tropomyosin'.

ATPase activity in muscle fibre lies with

  1. Light meromyosin

  2. Head of heavy meromyosin

  3. Troponin

  4. Short arm of heavy meromyosin


Correct Option: B
Explanation:
  • The myofibril is composed of two types of filaments. They are thick filament(Myosin) and Thin filament(Actin).
  • Increase in Ca++ level leads to the binding of calcium with a subunit of troponin i.e troponin-C on actin filaments and thereby remove the masking of active sites for myosin. Utilizing the energy from ATP hydrolysis, the myosin head now binds to the exposed active sites on actin to form a cross bridge.
  • Each myosin (thick) filament is also a polymerized protein. Many monomeric proteins called Meromyosins constitute one thick filament. Each meromyosin has the globular head which is an active ATPase enzyme and has binding sites for ATP and active sites for actin. Hence ATPase activity in muscle fibre lies with Head of heavy meromyosin.
  • So, the correct answer is 'Head of heavy meromyosin'.

Actin binding sites are located on:

  1. troponin

  2. tropomyosin

  3. meromyosin

  4. both (b) and (c)


Correct Option: C
Explanation:

Actin belongs to the family of globular multifunctional protein that forms microfilaments in muscle fibers. The associated proteins along with actin found in thin filaments are troponin and tropomyosin.however the binding sites are located in meromyosin.

So, the correct option is 'meromyosin'.

Which of the following proteins is found in the thick filaments of skeletal muscle?

  1. Actin

  2. Troponin

  3. Myosin

  4. Tropomyosin


Correct Option: C
Explanation:
A skeletal muscle is made up of different types of proteins. The thick filaments are made up of myosin while the thin filament is made up of three proteins actin, troponin, and tropomyosin. So, the correct answer is 'Myosin'.

Myoglobin is found in?

  1. Muscles

  2. Blood

  3. Lungs

  4. RBCs


Correct Option: A
Explanation:

  • Myoglobin is a protein found in muscles of almost all mammals that binds to both iron and oxygen. 
  • It is also made up of heme and globin protein. 
  • The main function of myoglobin is binding to oxygen and carrying it to different muscle tissues.
  • So, the correct answer is 'Muscles'.

Read the following statement (A-D) with regards to muscles.


Choose the correct option.

  1. I-bands are isotropic bands and made by actin filaments

  2. A-bands are anisotropic bands and made by both actin and myosin filaments

  3. In between I-bands thin fibrous M-line is present

  4. In between A-bands, thin fibrous M-line is present


Correct Option: A

Select the option where the property describing muscle fibres is not associated with wall of stomach.

  1. Presence of actin and myosin fibrils

  2. Branched, multinucleated appearance

  3. Presence of cell junctions

  4. Involuntary nature


Correct Option: A
Explanation:

The layers of stomach wall include serosa, muscularis, submucosa, and mucosa these are involuntary in nature and show the presence of cell junctions also, the muscularis layer shows branched and multinucleated appearance.

However, the presence of actin and myosin fibrils is seen in smooth muscles.
So, the correct answer is 'Presence of actin and myosin fibrils'.

Which fibres, contractile in nature are found in muscles?

  1. White fibres

  2. Myofibrils

  3. Micro fibrils

  4. Elastic fibres


Correct Option: B
Explanation:

Contractile fibres are those fibres which are capable in contraction of the muscles.

 Fibres Nature 
 White fibres (form of mature connective tissue)  Ineslastic
 Myofibrils (skeletal muscle)  Contractile
 Micro fibrils (surface of primary cell wall)  elastic
 Elastic fibres (bundle of connective tissue)  elastic

So, the correct  option is 'Myofibrils'

Which of the following are the regulatory protein in the  muscle contraction?

  1. Troponin and tropomyosin

  2. Troponin and actin

  3. Myosin and tropomyosin

  4. Actin and tropomyosin


Correct Option: A
Explanation:
  • Actin and myosin are the contractile proteins, and they interact with each other, causing contraction, while troponin and tropomyosin are regulatory proteins that regulate the interaction between actin and myosin. 
  • Myofilaments(actin and myosin) are packed in functional units of striated muscle referred to as sarcomeres. 
  • Hence, Troponin and tropomyosin are the regulatory protein in muscle contraction.
  • So, the correct answer is 'Troponin and tropomyosin'.

In the sarcoplasmic reticulum of resting muscle, Ca$^{2+} $ are held together by which protein?

  1. Nebulin

  2. Desmin

  3. Calsequestrin

  4. Calmodulin


Correct Option: D
Explanation:

In the sarcoplasmic reticulum of resting muscle, Ca2+ are held together by calmodulin. Calmodulin is also called as calcium-modulated protein, is a calcium-binding protein present in the cytoplasm. It is present in all eukaryotic cells.it's the function is to bind calcium ions in resting muscle. when the motor impulse is generated and reached to neuromuscular junctions calcium is released from calmodulin which facilitates muscle contraction.

So, the correct answer is 'Calmodulin'.

Actin binding sites are located on:

  1. Troponin

  2. Tropomyosin

  3. Eromyosin

  4. Both (b) and (c)

  5. Both (a) and (b)


Correct Option: A

Cross bridges between actin and myosin is broken up by

  1. Hydrolysis of AP

  2. Binding of ATP to the myosin head

  3. Binding of calcium to the subunit of troponin

  4. Exposure of tropomyosin


Correct Option: B
Explanation:
  • Each myosin (thick) filament is also a polymerized protein. Many monomeric proteins called Meromyosins constitute one thick filament.
  • Each meromyosin has two important parts, a globular head with a short arm and a tail. The globular head is an active ATPase enzyme and has binding sites for ATP and active sites for actin.
  • The globular head of a myosin molecule that projects from a myosin filament in muscle and is held to attach temporarily to an adjacent actin filament and draw it into the A band of a sarcomere between the myosin filaments to form a cross bridge.
  • Cross bridges between actin and myosin are broken up by Binding of ATP to the myosin head and The myosin, releasing the ADP and P1 and muscle goes back to its relaxed state.
  • So, the correct answer is 'Binding of ATP to the myosin head'.

Muscle cells contain _________ protein.

  1. Casein

  2. Actin

  3. Myosin

  4. Both B and C


Correct Option: D
Explanation:

Muscle is a soft tissue found in most animals. Muscle cells contain protein filaments of actin and myosin that slide past one another, producing a contraction that changes both the length and the shape of the cell. Therefore, (d) is the correct answer. 

Major protein in the thick filaments of skeletal muscle fiber is

  1. Myosin

  2. Actin

  3. Tropomyosin

  4. Troponin


Correct Option: A
Explanation:
  • Skeletal muscle fiber is made up of two types of filaments. They are thick filament and thin filament.
  • Thick filament is made up of a protein called Myosin.
  • Each myosin (thick filament) is made up of Many monomeric proteins called Meromyosins.
  • Hence Major protein in the thick filaments of skeletal muscle fiber is Myosin.
  • So, the correct answer is 'Myosin'.

Myosin filaments are localized in

  1. Z-Band

  2. H-Band

  3. A-Band

  4. None of the above


Correct Option: C
Explanation:
  • Each myofibril (muscle filament)has alternate dark and light bands on it. 
  • The light bands contain actin and are called I-band or Isotropic band, whereas the dark band called ‘A’ or Anisotropic band contains Myosin.
  • Myosin filaments are also called as Thick filaments.
  • Hence Myosin filaments are localized in A-Band.
  • So, the correct answer is 'A-Band'.

Which one of the following is wrongly matched.

  1. Myosin - Contractile protein

  2. Tendon - Connective tissue

  3. Smooth muscle - Involuntary muscle

  4. Red muscle - Myoglobin

  5. Troponin - Fibrous protein


Correct Option: E

Component of actin filament of a sarcomere is

  1. Myosin and troponin

  2. Troponin and actin

  3. Actin and myosin

  4. Actin, troponin and tropomyosin


Correct Option: D
Explanation:
  • Skeletal muscle fiber is made up of two types of filaments. They are thick filament(myosin) and thin filament(actin). 
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein Troponin is distributed at regular intervals on the tropomyosin.
  • Hence Component of actin filament of a sarcomere is Actin, troponin, and tropomyosin.
  • So, the correct answer is 'Actin, troponin, and tropomyosin'.

Which is wrongly matched?

  1. Red muscle-myoglobin

  2. Tendon-connective tissue

  3. Troponin-fibrous protein

  4. Smooth muscle-involuntary muscle

  5. Myosin-contractile protein


Correct Option: C
Explanation:
  • The myofibril is composed of two types of filaments. They are thick filament(Myosin) and Thin filament(Actin).
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein Troponin is distributed at regular intervals on the tropomyosin. In the resting state tropomyosin partially covers myosin binding site on actin. Tropomyosin is a fibrous protein and Troponin is a globular protein.
  • So, the correct answer is 'Troponin-fibrous protein'

Read the statements regarding muscle proteins and identify the correct statements
i. Actin is a thin filament and is made up of two F-actins
ii. Complex protein, tropomyosin is distributed at regular intervals on the troponin
iii. Myosin is a thick filament which is also a polymerized protein
iv. Globular head of meromyosin consists of light meromyosin (LMN)

  1. i, iii and iv are correct

  2. i and iii are correct

  3. i, ii and iii are correct

  4. i, ii and iv are correct

  5. ii and iv are correct


Correct Option: C
Explanation:
  • Myofibril is made up of two types of filaments.They are thin filament(actin) and thick filament(myosin).
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein Troponin is distributed at regular intervals on the tropomyosin.
  • Each myosin (thick) filament is also a polymerized protein. Many monomeric proteins called Meromyosins, constitute one thick filament. Globular head of meromyosin consists of Heavy meromyosin (HMM).
  • So, the correct answer is 'i, ii and iii are correct'

In a resting muscle fibre, tropomyosin partially covers

  1. Ca-binding sites on actin

  2. Ca-binding sites on troponin

  3. Actin binding sites on myosin

  4. Myosin binding sites on actin


Correct Option: D
Explanation:
  • The myofibril is composed of two types of filaments. They are thick filament (Myosin) and Thin filament (Actin).
  • Each actin (thin) filament is made of two ‘F’ (filamentous) actins helically wound to each other. Each ‘F’ actin is a polymer of monomeric ‘G’ (Globular) actins. Two filaments of another protein, tropomyosin also run close to the ‘F’ actins throughout its length. A complex protein Troponin is distributed at regular intervals on the tropomyosin. In the resting state tropomyosin partially covers myosin binding site on actin.
  • Increase in Ca++ level leads to the binding of calcium with a subunit of troponin i.e troponin-C on actin filaments and thereby remove the masking of active sites for myosin. Utilizing the energy from ATP hydrolysis, the myosin head now binds to the exposed active sites on actin to form a cross bridge.
  • Hence In a resting muscle fibre, tropomyosin partially covers myosin binding sites on actin.
  • So, the correct answer is 'Myosin binding sites on actin'.

Which one of the following is the thick filament of muscle?

  1. Actin

  2. Troponin

  3. Tropomyosin

  4. Myosin


Correct Option: D
Explanation:
  • Myofibril is made up of two types of filaments. They are thick filament (myosin) and thin filament (actin). Actin filaments are thinner as compared to the myosin filaments, hence are commonly called thin and thick filaments respectively
  • Each myosin (thick) filament is a polymerized protein. Many monomeric proteins called meromyosins constitute one thick filament.
  • Hence myosin is the thick filament of muscle.
  • So, the correct answer is 'Myosin'.

Which one of the following is wrongly matched?

  1. Myosin - contractile protein

  2. Tendon - connective tissue

  3. Smooth muscle - involuntary muscle

  4. Troponin - fibrous protein


Correct Option: D
Explanation:
A. Myosin are made up of polymerised protein which make thick myofilament. They are found in A- band of sarcomere and are contractile protein.
B. Tendon is dense regular connective tissue which join muscle to bone and made up of white collagen fibres.
C. Smooth muscle is non striated muscle with tapering ends and spindle shaped. They are involuntary muscles which are not under control and do not get fatigue.
D. Thin myofilament is made up of three proteins - actin, tropomyosin and troponin. Actin is a globular protein. Tropomyosin is a fibrous protein. At regular intervals of tropomyosin, a complex protein called troponin. It is a trimeric protein having three units - troponin I, troponin T and troponin C.
So, the correct answer is 'Troponin-fibrous protein'.

The microfilaments of a muscle

  1. Are arranged in compartments known as sarcomeres

  2. Are composed of proteins known as actin and myosin

  3. Are the actual contractile elements of the fibre

  4. All of the above


Correct Option: D
Explanation:

  • Myofilament is the filaments of myofibrils, constructed from proteins, principally myosin or actin.
  • They are made up of thick and thin myofilament, which helps to give it a striped appearance.
So, the correct option is 'all of the above'.

State whether the following statements are true or false.
Actin is actually a globular protein that assembles as a long beady structure consisting of two helical chains.

  1. True

  2. False


Correct Option: A
Explanation:

Skeletal muscle is composed of muscle fibres which have smaller units called myofibrils. There are three types of proteins make up each myofibril; they are contractile, regulatory and structural proteins. By contractile proteins, we mean actin (thin filament), a globular protein assembling with a long beady structure consisting chains and myosin (thick filament).

So, the correct option is 'True'.

The functional unit of myofibril is made up of

  1. Complete A-band

  2. Complete I-band

  3. Complete I-band and two half A-band

  4. Complete A-band and two half I-band


Correct Option: D

The proteins found in the filaments of muscle fibres are

  1. Actin and myosin

  2. Myosin and elastin

  3. Actin only

  4. Myelin and tubulin


Correct Option: A
Explanation:

Skeletal muscle is composed of muscle fibres which have smaller units called myofibrils. There are three types of proteins make up each myofibril; they are contractile, regulatory and structural proteins. By contractile proteins, we mean actin (thin filament) and myosin (thick filament).

So, the correct option is 'actin and myosin'.

The 'thick' filament in muscles is a polymerised protein of

  1. meromyosins

  2. actins

  3. troponins

  4. tropomyosins.


Correct Option: A

In the resting muscle fibre, tropomyosin partially covers

  1. calcium binding sites on troponin

  2. actin binding sites on myosin

  3. myosin binding sites on actin

  4. calcium binding sites on actin.


Correct Option: C
Explanation:

Tropomyosin is a protein found in the actin filaments in muscles. The molecule contains two elongated strands that run along the length of the filament. When the muscle is at rest, the tropomyosin molecule covers the binding site of the actin molecule, where interaction with myosin occurs, On contraction of the muscle, the tropomyosin is displaced by another protein, troponin, allowing the interaction of actin with myosin. So, the correct answer is (c).

Which of the following statements about the molecular arrangement of action and myosin in myofibrils is/are incorrect?
(i) Each actin (thin filament) is made of 2F (filamentous) actins.
(ii) F-actin is the polymer of G (globular) actin.
(iii) 2F-actins are twisted into a helix.
(iv) Two stands of tropomysion (protein) lie in the grooves of F-actin.
(v) Troponin molecurles (complex proteins) are distributed at regular intervals on the tropomyosin.
(vi) Troponin forms the head of the myosin molecule.
(vii) The myosin is a polymerised protein.

  1. (i), (ii) and (vi)

  2. (ii), (iv) and (v)

  3. only (vi)

  4. only (iii)


Correct Option: A
Explanation:

Following are the incorrect statements about the molecular arrangement of actin and myosin in myofibrils:

(i) Each actin (thin filament) is made of 2F (filamentous) actins.
(ii) F - actin is the polymer of G (globular) actin.
(iii) Troponin forms the head of the myosin molecule.
So, the correct answer is (a).

Which of the following contractile proteins contributes 55% of muscle protein by weight ?

  1. Tropomyosin

  2. Troponin

  3. Myosin

  4. Actin


Correct Option: C
Explanation:
Myosin is the protein that makes up the thick filaments and it comprises approximately 50-55% of the muscle protein by weight.
So, the correct answer is 'Myosin'.

Consider the following four statements (i) - (iv) and select the correct option.
(i) Actin is present in thin filament.
(ii) H-zone of striated muscle fibre represents both thick and thin filaments.
(iii) There are 11 pairs of ribs in man.
(iv) Sternum Is present on ventral side of the body. 

  1. (i) F (ii) F (iii) T (iv) F

  2. (i) F (ii) F (iii) F (iv) T

  3. (i) T (ii) F (iii) F (iv) F

  4. (i) T (ii) F (iii) T (iv) F


Correct Option: C
Explanation:

(i) Actin is present in thin filament - True

(ii) H-zone of striated muscle fibre represents both thick and thin filaments - False
(iii) There are 11 pairs of ribs in man - False
(iv) The sternum is present on the ventral side of the body - False
So, the correct answer is (c).

The linear protein that has catalytic function is _____________.

  1. actin

  2. collaagen

  3. mysoin

  4. trypsin


Correct Option: A
Explanation:
Actin usually exists as the globular monomer of G-actin and also as a polymer of F-actin. This F-actin is a linear chain of subunits of G-actin.
So, the correct answer is 'actin'.

Each actin filament is made of

  1. 2 'G' Actin molecules

  2. 2 F Actin molecules

  3. 1 F Actin molecules

  4. 1 G Actin molecules


Correct Option: B
Explanation:

Actin is the protein which helps in the muscle contraction. It present in two forms G actin (globular actin) and F actin (filament actin). In muscles, actin filament is formed by the two long strand of bead-like twisted actin molecule. 

So, the correct answer is '2 F Actin molecules'.

Contractile unit of muscle fibres is

  1. Muscle fibre

  2. Sacromere

  3. Myofibril

  4. Sacrosome


Correct Option: B
Explanation:

The entire cross section of the muscle fibre is taken up by long, cylindrical strands of contractile proteins called myofibrils. One myofibril is divided into segments called sarcomeres. These are the contractile units of a muscle. A dark stripe called a Z disc marks the ends of one sarcomere and the beginning of the next.

Contractile proteins include:

  1. Troponin

  2. Tropomyosin

  3. Actin and myosin

  4. All the three


Correct Option: C
Explanation:

The main components of protein in muscle is actin and myosine that form thin and thick fibers respectively.


The troponin and tropmyosine come under the category of regulatory proteins that regulate the process of muscle contraction.

for example troponin binds with tropomysosine to inhibit actin and myosine interaction during relaxation stage.

Hence the correct answer is (C). 

The important muscle proteins that help in movement are

  1. Actin and myosin

  2. Tropomyosin

  3. Troponin

  4. All of these


Correct Option: D
Explanation:

Actin and myosin are the structural filaments that play the main role in muscle contraction by sliding filament theory.

Troponin and tropomyosin are the regulatory proteins that regulate the rate of attachment of myosin heads to actin. Hence they also play an important role in muscle contraction and its movement.
Troponin regulate availability of active sites of actin by attaching with Ca++
So the correct option is D.

Actin is present in thin filament.

  1. True

  2. False


Correct Option: A
Explanation:

Actin is the thin filaments of the muscles. They are a polymer of G-actin monomers arranged in chains and two such chains are wound in a helix. So, the given statement is true.

The monomeric actin is called as

  1. F- actin

  2. M- actin

  3. G- actin

  4. N- actin


Correct Option: C
Explanation:

Actin is the thin filament of the muscles. It is a polymer made of many monomers. The monomers of actin are globular in shape and hence called Globular-actin or G-actin. Monomers together form straight chains of polymer action. The polymer action is called F-actin.

So the correct option is C.

In a muscle fibre

  1. Sacrolemma is connective tissue holding the myofibrils together

  2. T system contains calcium storage sacs

  3. Both filaments have cross-bridges

  4. All of the above


Correct Option: B
Explanation:
Terminal cisternae are enlarged areas of the sarcoplasmic reticulum surrounding the transverse tubule because terminal cisternae ensure rapid calcium delivery, they are well developed in muscles that contract quickly such as fast-twitch skeletal muscle.
So, the T system contains calcium storage sacs.

Choose the correct answer from the alternatives given.
The enormous diversity of protein molecules is mostly due to the diversity of:

  1. Amino groups on the amino acids

  2. K groups on the amino acids

  3. R groups on the amino acids

  4. Peptide bonds


Correct Option: C
Explanation:

There are 20 amino acids known. All the amino acids follow the basic structure. It consists of a carbon atom in the middle surrounded by three chemical bases.

Two out of three bases are the amino (NH$ _2$ group) and the carboxylic group (COOH). The third group is a simple hydrogen atom present in all the amino acids.
The fourth group is called an R group that determines the nature of the amino acid. This R group can be as simple as a hydrogen atom and may also contain complex rings. On the basis of the R group, the amino acid can be polar or non-polar, acidic or basic or neutral.
Thus the enormous diversity of protein molecules is mostly due to the diversity in the R group.
So, the correct option is 'R groups on the amino acids'.

State whether the following statements are true or false.
Actin is present in thin filament.

  1. True

  2. False


Correct Option: A
Explanation:

Skeletal muscle is composed of muscle fibres which have smaller units called myofibrils. There are three types of proteins make up each myofibril; they are contractile, regulatory and structural proteins. By contractile proteins, we mean actin (thin filament) and myosin (thick filament).

So, the correct option is 'True'.

Major protein constituent of muscle fibre is?

  1. Actin

  2. Myosin

  3. Tropomyosin

  4. Reticulin


Correct Option: B

Actin binding sites are located over

  1. Troponin

  2. Tropomyosin

  3. Meromyosin

  4. Creatnine

  5. Both A and B


Correct Option: C
Explanation:
  • The myofibril is composed of two types of filaments. They are thick filament(Myosin) and Thin filament(Actin).
  • Increase in Ca++ level leads to the binding of calcium with a subunit of troponin i.e troponin-C on actin filaments and thereby remove the masking of active sites for myosin. Utilizing the energy from ATP hydrolysis, the myosin head now binds to the exposed active sites on actin to form a cross bridge.
  • Each myosin (thick) filament is also a polymerized protein. Many monomeric proteins called Meromyosins constitute one thick filament. Each meromyosin has the globular head is an active ATPase enzyme and has binding sites for ATP and active sites for actin.
  • Hence actin binding sites are located over meromyosin'.
  • So, the correct answer is 'Meromyosin'.

Identify the thick myofilament from the given contractile proteins.

  1. Troponin 

  2. Myosin

  3. Tropomyosin

  4. Actin


Correct Option: B
Explanation:
  • Skeletal muscle fiber is made up of two types of filaments. They are thick filament and thin filament.
  • Thick filament is made up of a protein called Myosin. Actin filaments are thinner as compared to the myosin filaments, hence are commonly called thin and thick filaments respectively
  • Each myosin (thick filament) is made up of Many monomeric proteins called Meromyosins.
  • Hence the thick myofilament from the given contractile proteins is myosin.
  • So.the correct answer is 'Myosin'.

In skeleton muscle Z-line is connected to.

  1. Actin

  2. Myosin

  3. Tropomyosin

  4. Hensen's line


Correct Option: A
Explanation:

  • Each myofibril consists of a series of contractile units (sarcomeres) connected at a protein border (the Z line).
  •  Thin filaments(actin) of adjacent sarcomeres are present in the Z line between the thin filaments are thick filaments(myosin). 
  • The protein tropomyosin winds around the thin filaments and covers the myosin binding sites. Hence, In skeleton muscle, Z-line is connected to actin.
So, the correct answer is 'actin'.

Major protein in thick filaments of skeletal muscle fibre is?

  1. Myosin

  2. Actin

  3. Tropomyosin

  4. Troponin


Correct Option: A
Explanation:

  • The main contractile components of a muscle fibre include:
  •  Thick filaments - The major protein of a thick filament is myosin. 
  • Thin filaments - The major proteins of a thin filament include actin, as well as troponin and tropomyosin. Hence, Major protein in thick filaments of skeletal muscle fibre is myosin.
So, the correct answer is 'myosin'.

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