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Reproduction and Development in Humans

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Number of Questions: 15
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Tags: sexual reproduction Pregnancy and Parturition Pregnancy and Development Structure of Reproductive System Male Reproductive System
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What is the primary function of Leydig cells of the testes?

  1. Regulating pituitary secretion of prolactin

  2. Inhibin secretion

  3. Nitric oxide release

  4. Testosterone synthesis

  5. Synthesis of androgen binding protein


Correct Option: D
Explanation:

The primary function of Leydig cells is to synthesize and secrete testosterone. Leydig cells do this in a dose-dependent manner in response to LH.

Which of the following statements is false regarding the changes in penis during copulation?

  1. Although the penis is completely refractory to stimulation during the primary stage of the resolution phase, this stage is relatively longer.

  2. Contractions in the urethra, bulbocavernosus and ischiocavernosus muscles promotes ejaculation.

  3. Men cannot usually achieve an erection after spinal cord injuries.

  4. Muscular contractions in the prostate, seminal vesicles and vas deferens drives emission.

  5. During secondary involution, the penis progressively regains responsiveness.


Correct Option: A
Explanation:

The resolution phase of the male sexual cycle is divided into two parts. During the primary stage of involution, penile detumescence occurs; the penis reduces to 50% of its fully erect state and remains completely refractory to stimulation. This stage is relatively short.

Erection occurs after activation of which of the following?

  1. Parasympathetic nervous system.

  2. Sympathetic nervous system.

  3. Norepinephrine release.

  4. Serotonin release.

  5. Dopamine release.


Correct Option: A
Explanation:

Erection occurs after activation of the parasympathetic nervous system.

Which of the following statements concerning puberty in humans is true?

  1. Men are taller than women because the growth spurt in boys occurs earlier than in girls.

  2. The initial increase in gonadotropin secretion with the onset of puberty occur after the morning meal.

  3. Estrogen is involved in keratinization of the vaginal mucosa at puberty.

  4. Adrenarche always precedes thelarche.

  5. Testosterone is involved in the onset of puberty, playing a role in development of so-called secondary sex characteristics such as breasts, pubic and armpit hair.


Correct Option: C
Explanation:

During puberty, estrogen produced by the ovaries causes several changes in secondary sexual characteristic keratinization or cornification of the vaginal mucosa, enlargement of the labia minora and majora, uterine enlargement and increased fat deposition in the hips and thighs.

The vas deferens is important for which of the following functions of spermatogenesis?

  1. It consumes the unneeded portions of the spermatozoa

  2. Sperm transit

  3. Maintaining the blood–testis barrier

  4. Testosterone production

  5. Sperm storage


Correct Option: B
Explanation:

Both the epididymis and the vas deferens are made up of ducts which have muscular components. These muscular parts aid in peristalsis, which helps move spermatozoa along the ducts.

The mesenchyme arising beneath the germinal epithelium is the origin of which analogous cell types?

  1. Leydig and thecal cells

  2. Spermatogonia and oogonia

  3. Sertoli and granulosa cells

  4. Sex cords

  5. Umbilical cord


Correct Option: A
Explanation:

Mesenchyme arising beneath the germinal epithelium in the testes is the precursor to testicular interstitial cells or Leydig cells while in the ovaries, it is the precursor to ovarian stroma or thecal cells.

Which of the following is a true statement in an otherwise normal gestation in human beings?

  1. In the presence of SRY, a female phenotype will develop.

  2. In the absence of SRY, a female phenotype will develop.

  3. SRY is located on the X chromosome.

  4. Only one X chromosome is necessary for normal ovarian development.

  5. In humans, birth normally occurs at a gestational age of about 36 weeks.


Correct Option: B
Explanation:

It is correct. If SRY is absent, a fetus will develop into a female phenotype.

Maternal physiologic adaptations to pregnancy include all of the following except ________.

  1. vasodilatation

  2. increased tidal volume

  3. decreased renal glomerular filtration

  4. darkening of the skin on the cheeks

  5. increase in plasma volume


Correct Option: C
Explanation:

Renal glomerular filtration increases rather than decreases during pregnancy. Consider that during pregnancy the maternal circulating blood volume increases and along with that comes an increase in the renal blood flow simply because of the increased volume. An increase in renal blood flow correlates with an increase in the glomerular filtration rate. Filtration increases by as much as 50% by mid-pregnancy.

The hormone human chorionic gonadotropin is produced during pregnancy. It is secreted by ___________.

  1. fetal pituitary gland

  2. developing trophoblast

  3. maternal pituitary gland

  4. ovarian corpus luteum

  5. graafian follicle


Correct Option: B
Explanation:

After the conception and implantation have occurred, the developing embryonic trophoblast secretes hCG which acts like luteinizing hormone to maintain support of the corpus luteum.

Which of the following is not a function of Sertoli cells?

  1. Aromatization of androgen precursors to estrogen

  2. Maintenance of the blood–testis barrier

  3. Metabolic support of developing spermatozoa

  4. It acts as phagocytes

  5. Maintains the position of primordial germ cells against the basement membrane


Correct Option: E
Explanation:

Primordial germ cells are maintained against the basement membrane of the seminiferous tubules; Sertoli cells do not appear to have a role in this process.

What part of the embryo is the origin of the primordial germ cells?

  1. Gonadal ridge

  2. Endoderm of the yolk sack

  3. Coelomic epithelium

  4. Extraembryonic mesoderm

  5. Genital tubercle


Correct Option: B
Explanation:

In gonadal development, undifferentiated primordial germ cells arise from the endoderm lining the yolk sac. These germ cells detach and migrate dorsally to reach the coelomic epithelium lining the genital ridges.

A 27-year old European woman has been attempting pregnancy for 15 months. She is monitoring her ovulation with LH testing. Her test today indicated that she will ovulate tomorrow. In which phase will the ovulated germ cell be arrested?

  1. Prophase of the first mitotic division

  2. Anaphase of the first meiotic division

  3. Metaphase of the second meiotic division  

  4. Zygotic phase

  5. Meiotic prophase


Correct Option: C
Explanation:

During ovulation, the oocyte is arrested in the metaphase of the second meiotic division.

What is the glistening membrane called that covers the fetal surface of the placenta?

  1. Chorion

  2. Mesoderm

  3. Trophoblasts

  4. Amnion

  5. Decidua


Correct Option: D
Explanation:

Amnion is the membrane that surrounds and protects the fetal side of the placenta.

Which hormones initiate the growth of pubic and axillary hair?

  1. hCG

  2. FSH

  3. ACTH

  4. IGF-1

  5. DHEA and DHEA-S


Correct Option: E
Explanation:

In males and females, the adrenal gland produces and secretes increased amounts of several weak androgens during puberty: androstenedione, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S). DHEA and DHEA-S are responsible for the commencement of pubic and axillary hair growth.

In a pregnant female, which of the following develops into the placenta?

  1. A trophectoderm

  2. Inner cell mass of the blastocyst

  3. Decidua

  4. Myoblast cells

  5. Myometrium


Correct Option: A
Explanation:

The developing embryo has two main populations of cells: an inner cell mass and a trophectoderm. The trophectoderm cells lie at the outer surface of the developing embryo and will become the placenta.

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