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Gate Mixed Test

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Which of the following sets represents synthetic estrogens?

  1. Oestrone, oestriol, chlorotrianisene

  2. Stilboestrol, oestrone, fosfestrol

  3. Stilboestrol, oestriol, fosfestrol

  4. Chlorotrianisene, stilboestrol, fosfestrol

  5. Oestrone, oestriol, fosfestrol


Correct Option: D
Explanation:

Chlorotrianisene is a non-steroidal synthetic estrogen that was formerly used for the treatment of menopause, deficiencies in ovary function and prostate cancer. Stilboestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. Fosfestrol is a synthetic estrogen used as an antineoplastic agent.

Autoimmune thyroid disorders is/are caused by A. Coxsackie B virus B. Simian virus 40 C. Human papilloma virus

  1. Only A

  2. Only B

  3. Only C

  4. A and B

  5. B and C


Correct Option: A
Explanation:

Autoimmune thyroid disorders are conditions where the immune system attacks the thyroid gland. The immune system is the body's defense system against infections and diseases. A problem with the immune system may make the body attack even its own cells, including the thyroid gland. When this happens, the thyroid gland cannot work correctly. Autoimmune diseases are strongly associated with enteroviruses such as Coxsackie B virus.

Which of the following sets contains only cytokinins?

  1. Indole-3-butyric acid, Indole-3-acetic acid, 1-Naphthaleneacetic acid

  2. N6-furfuryladenine, zeatin, benzyl adenine

  3. N6-furfuryladenine, Indole-3-butyric acid, Indole-3-acetic acid

  4. N6-furfuryladenine, zeatin, Indole-3-butyric acid

  5. Zeatin, Indole-3-butyric acid, 1-Naphthaleneacetic acid


Correct Option: B
Explanation:

Kinetin (N6-furfuryladenine) is a type of cytokinin, a class of plant hormone that promotes cell division. Zeatin is a plant hormone derived from the purine adenine. It is a member of the plant growth hormone family known as cytokinins. Benzyl adenine or 6-Benzylaminopurine (BAP) is a first-generation synthetic cytokinin that elicits plant growth and development responses, setting blossoms and stimulating fruit richness by stimulating cell division.

Which of the following disorders is associated with glycogenosis and dextrinosis?

  1. Klinefelter's syndrome

  2. Drepanocytosis

  3. Ehlers–Danlos syndrome

  4. Alzheimer's disease

  5. von Gierke's disease


Correct Option: D
Explanation:

Glycogen storage disease type I or von Gierke's disease is the most common of the glycogen storage diseases or glycogenosis and dextrinosis. This genetic disease results from deficiency of the enzyme glucose-6-phosphatase. Alzheimer's disease is the most common form of dementia.

Match the column - I with column – II and choose the correct answer ||| |---|---| |Column – I |Column – II| |P. Glycine|1. Basic amino acid| |Q. Cysteine|2. Amino acid containing hydroxyl group| |R. Serine|3. Sulphur containing amino acid| |S. Arginine|4. lipotropic factor| | |5. Optically inactive amino acid|

  1. P - 5, Q - 3, R - 2, S - 1

  2. P - 4, Q - 2, R - 1, S - 5

  3. P - 3, Q - 1, R - 5, S - 4

  4. P - 2, Q - 5, R - 4, S - 3

  5. P - 1, Q - 4, R - 3, S - 2


Correct Option: A
Explanation:

This option is correct because all items of column I are correctly matched with column II.  Glycine - Optically inactive amino acid Cysteine - Sulphur containing amino acid Serine - Amino acid containing hydroxyl group Arginine - Basic amino acid.

Which among the following statements is/are true about microbiosensors?

  1. Microbiosensors are based on piezoelectric effect.
  2. Can be integrated on one chip and are useful for measuring various substrates in a small amount of sample solution simultaneously.
  3. It is possible to develop disposable transducers for biosensors through mass production.
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: E
Explanation:

Microbiosensors can be integrated on one chip and are useful for measuring various substrates in a small amount of sample solution simultaneously. It is possible to develop disposable transducers for biosensors through mass production.

Which of the following statements are not correct about penicillin production?

  1. Penicillin is produced by anaerobic fermentation.
  2. Inoculum preparation for the fermentation medium for penicillin takes place on barley seeds.
  3. Vegetable oil added in the fermentation medium for penicillin, act as source of nutrients.
  4. Penicillin is recovered after fermentation as potassium penicillin.
  1. 1 and 2

  2. 1 and 3

  3. 2 and 3

  4. 2 and 4

  5. 2, 3 and 4


Correct Option: B
Explanation:

Penicillin is produced by aerobic fermentation. Vegetable oil, (corn oil or soybean oil) added in the fermentation medium for penicillin, act as an antifoam agent.

Match the entries in Group-I (essential amino acids) with those in Group-II (corresponding functional groups/side chains) ||| |---|---| |Group-I |Group-II| |P. Histidine|1. hydroxy| |Q. Leucine|2. isobytyl| |R. Threonine|3. imidazole| |S. Tryptophan|4. indole|

  1. P - 3, Q - 2, R - 1, S - 4

  2. P - 3, Q - 4, R - 1, S - 2

  3. P - 3, Q - 4, R - 2, S - 1

  4. P - 1, Q - 2, R - 3, S - 4

  5. P - 2, Q - 1, R - 3, S - 4


Correct Option: A
Explanation:

Histidine is an alpha amino acid, the conjugate acid of the imidazole side chain. Leucine is a branched-chain α-amino acid with the chemical formula HO2CCH(NH2)CH2CH(CH3)2. Because of the presence of aliphatic isobutyl side chain, Leucine is hydrophobic in nature. Threonine is an α-amino acid with the chemical formula HO2CCH(NH2)CH(OH)CH3. This essential amino acid is classified as polar. Together with serine, threonine is one of two proteinogenic amino acids bearing an alcohol group (-OH group). Tryptophan is one of the 22 standard amino acids and is an essential amino acid in the human diet. It has indole as fuctional group. Hence, the correct match of codes is P - 3, Q - 5, R - 1, S - 4.

Which of the following sets of proteins provide protection and support, forming connective tissue, tendons, bone matrices, and muscle fiber?

  1. Hemoglobin, Myoglobin, Neuroglobin

  2. Collagen, Elastin, Neuroglobin

  3. Keratin, Collagen, Cytoglobin

  4. Neuroglobin, Fibroin, Elastin

  5. Collagen, Elastin, Keratin


Correct Option: E
Explanation:

This option is correct because this set of proteins provides protection and support, forming connective tissue, tendons, bone matrices, and muscle fiber. Keratin - A fibrous scleroprotein that occurs in the outer layer of the skin and in horny tissues, such as hair, feathers, nails, and hooves Collagen - A fibrous scleroprotein in bone and cartilage and tendon and other connective tissue; yields gelatin on boiling Elastin - A fibrous scleroprotein found in elastic tissues, such as the walls of arteries

Match the column - I with column – II and select the correct option ||| |---|---| |Column – I|Column – II| |A. Naramycin a|1. Streptomyces viridochromeogenes| |B. Flagecidin|2. Streptomyces griseus| |C. L-Alanyl-L-alanyl-phosphinothricin|3. Streptomyces griseolus|

  1. A - 1, B - 2, C - 3

  2. A - 1, B - 3, C - 2

  3. A - 2, B - 1, C - 3

  4. A - 2, B - 3, C - 1

  5. A - 3, B - 2, C - 1


Correct Option: D
Explanation:

Naramycin a is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Flagecidin, also known as Anisomycin, is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. L-Alanyl-L-alanyl-phosphinothricin is a natural herbicide produced by the bacteria Streptomyces hygroscopicus and Streptomyces viridochromeogenes.

Which of the following are examples of structural polysaccharides?

  1. Starch
  2. Cellulose
  3. Chitin
  4. Glycogen
  5. Pectin

    Note: Structural polysaccharides are the polysaccharides that are found to form the structure of an organism.
    Storage polysaccharides are store in the organ of plants and animals.

  1. Only 1 and 2

  2. Only 1, 2 and 3

  3. 2, 3 and 5

  4. 2, 3 and 4

  5. 1, 2, 3, 4 and 5


Correct Option: D
Explanation:

Yes, this is correct. Structural polysaccharides are the polysaccharides that are found to form the structure of an organism. Cellulose is found plants, chitin is  found in outer skeleton of insects and crabs, and pectin is a structural heteropolysaccharide contained in the primary cell walls of terrestrial plants.

Match the column - I with column – II and select the correct option ||| |---|---| |Column – I |Column – II| |P. Polymerase chain reaction|1. for monoclonal antibody production| |Q. Ti plasmid|2. for breaking bond between insulin and galactosidase| |R. CNBr|3. for introducing foreign genes into plants| |S. Hybridoma technology|4. for gene amplification|

  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 2, Q - 1, R - 4, S - 3

  3. P - 3, Q - 2, R - 1, S - 4

  4. P - 4, Q - 3, R - 2, S - 1

  5. P - 1, Q - 2, R - 4, S - 3


Correct Option: D
Explanation:

Hybridoma is a cell that is produced in the laboratory from the fusion of an antibody-producing lymphocyte and a nonantibody-producing cancer cell, usually a myeloma or lymphoma. It proliferates and produces a continuous supply of a specific monoclonal antibody. During recombinant insulin synthesis, the bond between insulin polypeptide and galactosidase can be removed by using cyanogen bromide. The Ti plasmid (tumor-inducing plasmid) of Agrobacterium tumefaciens has been developed as a vehicle for introducing foreign genes into plants. Polymerase Chain Reaction (PCR), is a technology used for amplifying DNA sequences.

Match the following drugs with their plant source and medical use |||| |---|---|---| |Drug |Plant source |Medical use| |P. Quinine|i. Atropa belladonna|1. Antimalarial| |Q. Reserpine|ii. Camellia sinensis|2. Tranquilizer| |R. Caffeine|iii. Cinchona ledgeriana|3. Anticholinergic| |S. Atropine|iv. Rawvolfia serpentina|4. CNS stimulant|

  1. P - ii - 3, Q - iv - 1, R - i - 2, S - iii - 4

  2. P - iii - 1, Q - iv - 2, R - ii - 4, S - i - 3

  3. P - ii - 2, Q - iii - 4, R - iv - 3, S - i - 1

  4. P - i - 2, Q - ii - 4, R - iii - 2, S - iv - 3

  5. P - i - 4, Q - iii - 1, R - ii - 3, S - iv - 2


Correct Option: B
Explanation:

Quinine, obtained from Cinchona ledgeriana, is a very commonly used anti-malarial drug. Reserpine, an alkaloid obtained from the roots of Rauwolfia serpentina, is used as tranquilizer. Caffeine is a bitter, white crystalline xanthine alkaloid and a stimulant drug obtained from Camellia sinensis. In humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. Atropine, an anticholinergic agent obtained from Atropa belladonna, is used as premedication in anaesthesia to reduce upper respiratory secretions.

Assertion: The inhibition of glycolysis by oxygen is referred to as Pasteur effect. Reason: This is due to inhibition of the enzyme phosphohexokinase by ATP and 2-hydroxypropane-1,2,3-tricarboxylate (formed in the presence of oxygen).

Directions: In the following question there are two statements, Assertion (A) and Reason (R), consider both the statements independently and mark your answers as under:
1. A and R both are correct and R is correct explanation of A.
2. A and R both are correct and R is not correct explanation of A.
3. A is correct and R is incorrect.
4. A is incorrect and R is correct.
5. A and R both are incorrect.

  1. A and R both are correct and R is the correct explanation of A.

  2. A and R both are correct and R is not the correct explanation of A.

  3. A is correct and R is incorrect.

  4. A is incorrect and R is correct.

  5. A and R both are incorrect.


Correct Option: A
Explanation:

Both Assertion (A) and Reason (R) are correct and R is the correct explanation of A. The inhibition of glycolysis by oxygen is referred to as Pasteur effect. This is due to inhibition of the enzyme phosphohexokinase by ATP and 2-hydroxypropane-1,2,3-tricarboxylate (citrate) (formed in the presence of oxygen).

Assertion: The normal role of restriction endonucleases in the bacterial cells is to degrade invading phage DNA. Reason: Bacterial cells protect their own DNA from degradation by restriction endonucleases by methylating the DNA at the sites that the enzyme recognizes.

Directions: In the following question there are two statements, Assertion (A) and Reason (R), consider both the statements independently and mark your answers as under:
1. A and R both are correct and R is correct explanation of A.
2. A and R both are correct and R is not correct explanation of A.
3. A is correct and R is incorrect.
4. A is incorrect and R is correct.
5. A and R both are incorrect.

  1. A and R both are correct and R is the correct explanation of A.

  2. A and R both are correct and R is not the correct explanation of A.

  3. A is correct and R is incorrect.

  4. A is incorrect and R is correct.

  5. A and R both are incorrect.


Correct Option: A
Explanation:

The normal role of restriction endonucleases in bacterial cells to degrade invading phage DNA because bacterial cells protect their own DNA from degradation by restriction endonucleases by methylating the DNA at the sites that the enzyme recognizes. Thus, this option is correct.

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