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Diversity of Living World

Description: This test will help the students to revise the topic virus thoroughly as it covers major portion of the topic.
Number of Questions: 15
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Tags: viruses Virus
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An old man is suffering from epidermodysplasia verruciformis. He is most likely to be infected by

  1. papillomavirus

  2. Polyomavirus

  3. simian virus 40

  4. adenovirus

  5. herpesvirus


Correct Option: A
Explanation:

Papillomavirus have a genome size about 8 kilobases. They cause warts and also human and animal cancers. Warts are usually benign but can convert to malignant carcinomas. This occurs in patients with epidermodysplasia verruciformis.

EBV is the herpes virus that is most strongly associated with cancer. Which among the following diseases are not caused by EBV?

  1. Burkitt's lymphoma

  2. Nasopharyngeal cancer

  3. B cell lymphomas

  4. Hodgkin's lymphoma

  5. X-linked MASA syndrome


Correct Option: E
Explanation:

MASA syndrome, is a rare X-linked recessive neurological disorder. It is caused by mutations in the L1CAM gene.

Which of the following is a common viral disease of wrestlers?

  1. Eczema herpeticum

  2. Herpes gladiatorum

  3. Herpes whitlow

  4. Herpes keratitis

  5. Oral herpes


Correct Option: B
Explanation:

This is contracted by wrestlers. It apparently spreads by direct contact from skin lesions on one wrestler to his / her opponent, and usually appears in the head and neck region (which are frequently sites of contact in wrestling holds).

Kavita is a patient of plasmablastic lymphoma which is a rare and aggressive variant of diffuse large B cell lymphoma. Which among the following viruses causes hematologic malignancies in such patients?

  1. Human herpes virus 4

  2. HHV-8, Kaposi's sarcoma herpes virus

  3. Human herpes virus 5

  4. Human herpes virus 3

  5. Cytomegalovirus


Correct Option: B
Explanation:

HHV-8 infects lymphocytes and epithelial / endothelial cells and is the causative agent of Kaposi's sarcoma. It has also been associated with hematologic malignancies, including primary effusion lymphoma, multicentric Castleman's, MCD-related immunoblastic / plasmablastic lymphoma.

In which of the following viral diseases, the infants have distinctive abnormalities at birth due to the mother's infection with chickenpox in the first trimester of pregnancy?

  1. Genital herpes

  2. HSV proctitis

  3. HSV Encephalitis

  4. HSV Meningitis

  5. Congential Varicella syndrome


Correct Option: E
Explanation:

Congenital Varicella Syndrome is an extremely rare disorder in which affected infants have distinctive abnormalities at birth (congenital) due to the mother's infection with chickenpox (maternal varicella zoster) early during pregnancy (i.e., up to 20 weeks gestation).

In a virus, the RNA genome covering protein is:

  1. G Protein

  2. M protein

  3. L protein

  4. N protein

  5. Gag-onc fusion protein


Correct Option: D
Explanation:

This is the major structural protein and covers the RNA genome. It protects the genome from nucleases and holds it in a conformation that allows transcription.

The viruses having the ‘Star of David’ appearance are:

  1. calicivirus

  2. norwalk virus

  3. astrovirus

  4. torovirus

  5. cytomegalovirus


Correct Option: A
Explanation:

Human calicivirus are non-enveloped, single stand, positive sense RNA viruses. They appear round in shape with icosahedral symmetry and contain a single capsid protein. The viral surface has 32 cup-shaped depressions described as the ‘Star of David’ appearance.

After a complete medical checkup, doctor told Himani that her brother is suffering from a severe viral disease in which the oligodendrocytes, the myelinating cells of the central nervous system are damaged. Which among the following diseases is the doctor referring to?

  1. Kuru

  2. Scrapie

  3. Progressive rubella panencephalitis (PRP)

  4. Subacute sclerosing panencephalitis (SSPE)

  5. Progressive multifocal leukoencephalopathy (PML)


Correct Option: E
Explanation:

This is a rare, progressive, fatal, demyelinating disease of the CNS that kills oligodendrocytes. It results in memory loss, loss of co-ordination, mentation problems, vision problems, etc. The disease is caused by certain members of the polyomavirus family, usually JC virus.

Which among the following proteins is activated by double-stranded RNA and protects against viral infections?

  1. NSP5

  2. NSP4

  3. NSP1

  4. PKR

  5. NS1


Correct Option: D
Explanation:

Protein kinase R (PKR) is an enzyme which protects against viral infections. PKR is activated by double-stranded RNA (dsRNA), the synthesis of which is caused virally.

Which among the following is an oncoprotein of the Epstein–Barr virus (EBV)?

  1. HBsAg

  2. HBcAg

  3. HBx

  4. NSP2

  5. LMP1


Correct Option: E
Explanation:

LMP1 is the best-documented oncoprotein of the Epstein–Barr virus (EBV), latent gene products.

Which among the following is not a symptom of mumps?

  1. Parotitis

  2. Deafness

  3. Pericarditis

  4. Pancreatitis

  5. Meningitis


Correct Option: C
Explanation:

Pericarditis is an inflammation of the pericardium, which is the fibrous sac surrounding the heart. A characteristic chest pain is often present. This is not associtaed with mumps.

Chimpanzees and humans differ by just over one percent of DNA. Which among the following viruses have been involved in the process of speciation, making the chimpanzee and human lines diverge?

  1. Retrovirus

  2. Spumaviruses

  3. Pan troglodytes Endogenous Retrovirus-1

  4. Lentiviruses

  5. Feline leukemia virus


Correct Option: C
Explanation:

Pan troglodytes Endogenous Retrovirus-1 is a retrovirus that putatively infected chimpanzees about 4 million years ago, and may have been involved in the process of speciation, making the chimpanzee and human lines diverge.

APOBE is a family of evolutionary conserved proteins. Which among the following viral factors disrupts the antiviral activity of this human enzyme?

  1. Tat

  2. Rev

  3. Vpr

  4. Nef

  5. Vif


Correct Option: E
Explanation:

Vif stands for viral infectivity factor. It is a protein found in HIV and other retroviruses. Its role is to disrupt the antiviral activity of the human enzyme APOBEC by targeting it for ubiquitination and cellular degradation.

An oncovirus is a virus that can cause cancer. Which among the following is the first described oncovirus?

  1. Bovine immunodeficiency virus

  2. Visna virus

  3. Rous sarcoma virus

  4. Avian sarcoma leukosis virus

  5. Koala retrovirus


Correct Option: C
Explanation:

Rous sarcoma virus is a retrovirus and is the first oncovirus to have been described. It causes sarcoma in chickens.

Which among the following blocks the tyrosine kinase signaling in the host cell?

  1. Gp41

  2. NSP2

  3. E2

  4. LMP-2A

  5. Vpu


Correct Option: D
Explanation:

LMP-2A is a transmembrane protein that act to block tyrosine kinase signaling. It inhibits activation of the viral lytic cycle.

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