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Proteins and Their Functions (GATE - XL)

Description: Proteins and Their Functions, GATE - XL, Proteins
Number of Questions: 15
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Tags: Proteins and Their Functions GATE - XL Proteins
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Which of the following proteins plays an important role in the precise interactions between photoreceptor neuronal synapse and the bipolar dendrons?

  1. Pikachurin

  2. Arp2/3

  3. FtsZ

  4. Keratin

  5. Elastin


Correct Option: A
Explanation:

This option is correct. Pikachurin plays an important role in the precise interactions between photoreceptor neuronal synapse and the bipolar dendrons.

In humans, which of these proteins is secreted by the cells of floor plate?

  1. Fibronectin

  2. Integrin

  3. F-spondin

  4. Selectin

  5. Protein Z


Correct Option: C
Explanation:

This option is correct. In humans, F-spondin is secreted by the cells of floor plate.

Which of the following proteins connect(s) the cytoskeleton of a myocyte to the surrounding extracellular matrix through the cytoplasmic membrane?

  1. Dystrophin

  2. Tubulin

  3. Fibronectin

  4. Ribonucleoprotein

  5. Chaperones


Correct Option: A
Explanation:

Dystrophin is a rod-shaped cytoplasmic protein that connects the cytoskeleton of a myocyte to the surrounding extracellular matrix through the cytoplasmic membrane.

Which of the following pairs of 'protein - its function' is incorrectly matched?

  1. Antiporter - involved in secondary active transport of two or more different molecules or ions across a phospholipid membrane

  2. Uniporter - integral membrane protein that is involved in facilitated diffusion

  3. Cotransporters - downward movement of one solute from high to low concentration to move another molecule upward from low to high concentration

  4. Symporter - transports differing types of molecules across the cell membrane

  5. Antiport - two species of ion or other solutes are pumped in opposite directions across a membrane


Correct Option: C
Explanation:

This option is correct. Symport is a downward movement of one solute species from high to low concentration to move another molecule upward from low concentration to high concentration. Cotransporters couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient.

Which of the following statements is/are incorrect about G protein-coupled receptors?

A. They are found in all eukaryotes and prokaryotes. B. They are involved in many diseases and target approximately 40% of all modern medicinal drugs. C. When a ligand binds to a GPCR, it causes a conformational change in the GPCR.

  1. Only A

  2. Only B

  3. Only C

  4. Only A and B

  5. Only B and C


Correct Option: A
Explanation:

This option is correct. G protein-coupled receptors are found only in eukaryotes.

Which of the following statements is/are false about DNA binding proteins?

  1. In humans, replication protein A is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair.
  2. DNA-binding proteins have specific affinity for only double stranded DNA.
  3. Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA.
  1. Only 1

  2. Only 2

  3. Only 3

  4. Only 1 and 2

  5. Only 2 and 3


Correct Option: B
Explanation:

This option is correct. DNA-binding proteins have a specific affinity for either single stranded or double stranded DNA.

Match the following.

 
Column – I Column – II
A. CFTR 1. Membrane protein
B. CRP 2. Glycoprotein
C. Protein S 3. Light-sensitive receptor protein
D. Rhodopsin 4. Pentameric protein
  1. A - 1, B - 2, C - 3, D - 4

  2. A - 1, B - 4, C - 2, D - 3

  3. A - 2, B - 4, C - 3, D - 1

  4. A - 2, B - 3, C - 4, D - 1

  5. A - 4, B - 1, C - 2, D - 3


Correct Option: B
Explanation:

This option is correct. CFTR (Cystic fibrosis transmembrane conductance regulator) is a membrane protein. CRP (C-reactive protein) is a pentameric protein. Protein S is a glycoprotein. Rhodopsin is a light-sensitive receptor protein.

Which of the following multi-functional globular proteins is/are found in all eukaroyotic cells, except nematode sperm?

  1. Actin

  2. Tubulin

  3. Complement proteins

  4. Collagen

  5. C1-inhibitor


Correct Option: A
Explanation:

This option is correct. Actin is a multi-functional globular protein found in all eukaroyotic cells, except nematode sperm.

Match the following.

 
List – I List – II
P. Histone 1. Globular protein
Q. Protamine 2. Y-shaped protein
R. Immunoglobulin 3. Nuclear protein
S. Ferritin 4. Alkaline protein
  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 1, Q - 3, R - 2, S - 4

  3. P - 2, Q - 4, R - 3, S - 1

  4. P - 2, Q - 3, R - 4, S - 1

  5. P - 4, Q - 3, R - 2, S - 1


Correct Option: E
Explanation:

This option is correct. Histone, protamine, immunoglobulin and ferritin are alkaline protein, nuclear protein, Y-shaped protein and globular protein, respectively.

Which of the following proteins protects from strokes and neural regeneration?

  1. Ependymin

  2. Integrin

  3. Cadherin

  4. Selectin

  5. NCAM


Correct Option: A
Explanation:

This option is correct. Ependymin protects from strokes and neural regeneration.

Which of the following statements is/are true about spheroproteins?

P. Spheroproteins form adducts in water, unlike fibrous or membrane proteins. Q. The spherical structure is induced by the protein's tertiary structure. R. Globular proteins have a mechanism for protein folding, which is nucleation condensation model.

  1. Only P

  2. Only Q

  3. Only R

  4. Only P and Q

  5. Only P and R


Correct Option: B
Explanation:

This option is correct because spherical structure is induced by the protein's tertiary structure.

Which of the following plays an important role in maintaining the shape of erythrocytes and regulating their membrane material properties?

  1. Scramblase

  2. CFTR

  3. Hemeprotein

  4. Ependymin

  5. Glycophorin C


Correct Option: E
Explanation:

This option is correct. Glycophorin C plays an important role in maintaining erythrocyte shape and regulating membrane material properties.

Which of the following statements is/are incorrect about acute-phase proteins?

A. The liver responds by producing a large number of acute-phase proteins. B. Positive acute-phase proteins serve similar physiological functions for the immune system. C. Negative acute-phase proteins decrease inflammation.

  1. Only A

  2. Only B

  3. Only C

  4. Only A and B

  5. Only B and C


Correct Option: B
Explanation:

This option is correct. Positive acute-phase proteins serve different physiological functions for the immune system.

Which of the following proteins circulating in the blood inhibits factors Xa and XIa of the clotting cascade?

  1. Factor XIII

  2. Protein Z-related protease inhibitor

  3. Factor VIII

  4. Protein S

  5. Protein C


Correct Option: B
Explanation:

This option is correct. Protein Z-related protease inhibits factors Xa and XIa of the clotting cascade.

Match the column – I (Proteins) with column – II (Immune system function).

 
Column – I Column – II
A. Alpha 2-macroglobulin 1. Inhibitor of fibrinolysis by inhibiting plasmin
B. Hepcidin 2. Induction of enzymes that degrade extracellular matrix
C. Serum amyloid A 3. Opsonin on microbes
D. C-reactive protein 4. Stimulates the internalisation of ferroportin
  1. A - 1, B - 2, C - 3, D - 4

  2. A - 1, B - 4, C - 2, D - 3

  3. A - 2, B - 4, C - 3, D - 1

  4. A - 2, B - 3, C - 4, D - 1

  5. A - 4, B - 1, C - 2, D - 3


Correct Option: B
Explanation:

This option is correct. Alpha 2-macroglobulin - Inhibitor of fibrinolysis by inhibiting plasmin Hepcidin - Stimulates the internalisation of ferroportin Serum amyloid A - Induction of enzymes that degrade extracellular matrix C-reactive protein - Opsonin on microbes  

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