0

Biochemistry

Description: Biochemistry Chemistry Bioinorganic chemistry Inorganic chemistry Life Sciences Biology Proteins Enzymes Metalloproteins GATE CSIR NET Life Sciences
Number of Questions: 20
Created by:
Tags: Biochemistry Chemistry Bioinorganic chemistry Inorganic chemistry Life Sciences Biology Proteins Enzymes Metalloproteins GATE CSIR NET
Attempted 0/20 Correct 0 Score 0

Which of the following is a copper transport protein?

  1. Hemoglobin

  2. Myoglobin

  3. Hemocyanin

  4. Ceruloplasmin

  5. Plastocyanin


Correct Option: D
Explanation:

Ceruloplasmin, a glycoprotein produced in the liver, carries or transports more than 95 percent of the copper in blood plasma.

Which of the following is a metal containing vitamin?

  1. Vitamin A

  2. Vitamin B5

  3. Vitamin B12

  4. Vitamin D

  5. Vitamin K


Correct Option: C
Explanation:

Vitamin B12 (cyanocobalamin) is the only vitamin that contains a metal (cobalt).

Which of the following is a selenium containing enzyme?

  1. Glutathione peroxidase

  2. Carbonic anhydrase

  3. Urease

  4. Dopamine beta-hydroxylase

  5. Tyrosinase


Correct Option: A
Explanation:

Selenium is an important constituent of the enzyme glutathione peroxidase, which is responsible for destroying lipid-damaging peroxides.

Iron is an extremely important transition metal in biology. It helps to perform many different biological functions such as

  1. transport of O2 to tissues
  2. release of O2 to muscle cells
  3. cofactor to some enzymes
  1. Only 1

  2. Only 2

  3. Only 3

  4. Only 1 and 2

  5. 1, 2 and 3


Correct Option: E
Explanation:

Hemoglobin is an iron containing oxygen transport metalloprotein, which transports O2 from the lungs to the tissues. Myoglobin, an iron containing protein in muscle, receives oxygen from the red blood cells and transports it to the mitochondria of muscle cells. Many enzymes vital to life contain iron, such as catalase, lipoxygenases, and IRE-BP.

Which of the following statements is/are correct about hemoglobin?

  1. Each hemoglobin molecule can combine with two O2 molecules.
  2. Each hemoglobin molecule contains two globin units with two heme units.
  3. Deoxy- and oxyhemoglobin have different colours.
  1. Only 1

  2. Only 2

  3. Only 3

  4. Only 1 and 2

  5. Only 2 and 3


Correct Option: C
Explanation:

Deoxy- and oxyhemoglobin have different colours. This is why the blood in our arteries (oxyhemoglobin) is brighter red than the blood in our veins (deoxyhemoglobin).

Which of the following drugs is used for cancer treatment?

  1. Amoxicillin

  2. Cefuroxime

  3. Budotitane

  4. Atenolol

  5. Bismuth subsalicylate


Correct Option: C
Explanation:

Budotitane is the drug used for cancer treatment. So, this option is correct.

Which of the following is used as anti-copper agent in Wilson’s disease?

  1. Tetrathiomolybdate

  2. Selenium sulphide

  3. Silver sulfadiazine

  4. Technetium

  5. Barium sulphate


Correct Option: A
Explanation:

 Tetrathiomolybdate is used as anti-copper agent in Wilson’s disease.

Which of the following is/are example(s) of copper containing enzyme(s)? P. Carbonic anhydrases Q. Urease| R. Catechol dioxygenase S. Galactose oxidase

  1. Only P

  2. Only Q and R

  3. Only R

  4. Only R and S

  5. Only S


Correct Option: E
Explanation:

Galactose oxidase is a monomeric enzyme that contains a single copper ion and catalyses the stereospecific oxidation of primary alcohols to their corresponding aldehydes.

Which of the following elements is present in budotitane?

  1. Ti

  2. Sn

  3. As

  4. Co

  5. Mo


Correct Option: B
Explanation:

Sn (Tin) is present in budotitane used to treat cancer. So, this option is correct.

Which of the following sets represent micronutrients only?

  1. Na, Ca, P, Cl, Fe

  2. Mn, Cu, Zn, Mo, Se

  3. Ca, Fe Mn, Zn, Mo

  4. P, Cl, Cu, Zn, Mo

  5. Mn, Ca, P, Zn, Fe


Correct Option: B
Explanation:

Micronutrients are nutrients required by humans and other organisms throughout life in small quantities to orchestrate a range of physiological functions. Examples: Mn, Co, Ni, Cu, Zn, V, Cr, Mo, Se, F, I, Al, Pb, Sn, Si

Which of the following matches of metalloenzyme and metal cofactors are incorrect? P. Tyrosinase : Copper Q. Urease : Copper R. Dopamine β-hydroxylase : Nickel S. Catechol dioxygenase : Iron

  1. Only P and Q

  2. Only P and S

  3. Only Q and R

  4. Only Q and S

  5. Only R and S


Correct Option: C
Explanation:

Urease is a nickel containing metalloenzyme of high molecular weight that catalyses the hydrolysis of urea into carbon dioxide and ammonia. Dopamine β-hydroxylase is a copper containing enzyme that synthesises norepinephrine from dopamine.

Match entries in Column I and Column II and select the correct answer.

 
Column - I
Column - II
P. Arginase 1. Zn
Q. Phosphotransferase 2. Mn
R. Cytochrome Oxidase 3. Mg
S. Alcohol dehydrogenase 4. Cu
  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 1, Q - 3, R - 4, S - 2

  3. P - 2, Q - 4, R - 3, S - 1

  4. P - 2, Q - 3, R - 4, S - 1

  5. P - 3, Q - 1, R - 4, S - 2


Correct Option: D
Explanation:

Metalloenzymes are proteins, which function as an enzyme and contain metals. For example: Arginase containing Mn2+, Phosphotransferase (Mg2+), Cytochrome Oxidase (Cu2+), Alcohol dehydrogenase (Zn2+), etc.

Which of the following is a tungsten containing metalloenzyme?

  1. Formaldehyde ferredoxin oxidoreductase
  2. Carboxypeptidase A
  3. Carbon monoxide dehydrogenase
  1. Only 1

  2. Only 2

  3. Only 3

  4. Only 1 and 2

  5. Only 2 and 3


Correct Option: A
Explanation:

Formaldehyde ferredoxin oxidoreductase is a tungsten containing metalloenzyme.

Which of the following are biological functions of Mg+2?

  1. Present in chlorophyll and helps in photosynthesis
  2. Activation of enzymes
  3. Information carrier
  4. Osmotic balance
  1. 1 and 2 only

  2. 1, 2 and 3 only

  3. 1, 2 and 4 only

  4. 2 and 4 only

  5. 2, 3 and 4 only


Correct Option: B
Explanation:

Mg is present in chlorophyll and helps in photosynthesis. It is helpful in activation of some enzymes. It also act as an information carrier.

Pernicious anemia is one of the obvious symptoms of __________ deficiency.

  1. molybdenum

  2. calcium

  3. nickel

  4. cobalt

  5. magnesium


Correct Option: D
Explanation:

Pernicious anemia is one of the obvious symptoms of a cobalt deficiency.

Match entries in Column I (elements) and Column II (used in the treatment of) and select the correct answer.

 
Column - I
Column - II
P. Li 1. Gastritis
Q. Pt 2. Rheumatoid arthritis
R. Au 3. Bipolar disorder
S. Bi 4. Cancer
  1. P - 4, Q - 2, R - 1, S - 3

  2. P - 3, Q - 4, R - 1, S - 2

  3. P - 2, Q - 3, R - 4, S - 1

  4. P - 1, Q - 4, R - 2, S - 3

  5. P - 1, Q - 3, R - 2, S - 4


Correct Option: B
Explanation:

Lithium salts are widely used to treat bipolar disorder (BPD). The square planar Pt(II) complex, cis-platin is used in chemotherapy of cancer. Various gold compounds have been used in the treatment of rheumatoid arthritis. All are Au(I) complexes containing thiolate ligands. Bismuth salts are used in treatment of gastritis.

Which of the following is/are copper containing proteins involved in electron transfer?

  1. Plastocyanin
  2. Ceruloplasmin
  3. Amicyanin
  1. Only 1

  2. Only 1 and 3

  3. Only 2

  4. Only 2 and 3

  5. 1, 2 and 3


Correct Option: B
Explanation:

Plastocyanin is a copper containing protein involved in electron transfer. Amicyanin is a type I copper protein that plays an integral role in electron transfer.

Which of the following are examples of iron-sulphur proteins?

  1. Rubredoxin
  2. Methane monooxygenase
  3. Rieske proteins
  4. Aconitase
  1. 1 and 2 only

  2. 1, 2 and 3 only

  3. 1, 3 and 4 only

  4. 2 and 3 only

  5. 2, 3 and 4 only


Correct Option: C
Explanation:

Rubredoxin is a small iron-sulphur protein found in various sulphur-metabolising bacteria. Rieske proteins are iron-sulphur protein components of cytochrome bc1 complexes and cytochrome b6f complexes, which were first discovered and isolated by John S. Rieske and co-workers in 1964. Aconitase is an iron-sulphur protein that catalyses the interconversion of citrate and isocitrate.

Match entries in Column I (elements) and Column II (their medical uses) and select the correct answer.

 
Column - I
Column - II
P. Selenium 1. Anti-dandruff
Q. Magnesium 2. Antacid
R. Antimony 3. Antileishmaniasis
S. Tin 4. Anti-caries
  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 1, Q - 3, R - 2, S - 4

  3. P - 2, Q - 1, R - 4, S - 3

  4. P - 2, Q - 3, R - 1, S - 4

  5. P - 4, Q - 3, R - 2, S - 1


Correct Option: C
Explanation:

Wrong matching. Correct matching is given in option 1.

Match the following.

Column - I Column - II
P. Mitochondria 1. Site for protein synthesis
Q. Ribosomes 2. Powerhouse of cell
R. Chloroplasts 3. Suicidal bags of cell
S. Lysosomes 4. Site for photosynthesis
  1. P - 1, Q - 2, R - 3, S - 4

  2. P - 2, Q - 3, R - 1, S - 4

  3. P - 2, Q - 1, R - 4, S - 3

  4. P - 3, Q - 2, R - 4, S - 1

  5. P - 3, Q - 1, R - 4, S - 2


Correct Option: C
Explanation:

 Correct answer is given below. Mitochondria : Powerhouse of cell Ribosomes : Site for protein synthesis Chloroplasts : Site for photosynthesis Lysosomes : Suicidal bags of cell

- Hide questions