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Human Physiology (NEST)

Description: This test will help the students to revise their topics thoroughly.
Number of Questions: 16
Created by:
Tags: Circulatory system and Respiratory system Human Heart Structure of Reproductive System Embryogenesis Lymphatic System
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Which of the following structures is present in the right ventricle of mammals?

  1. Orifice of pulmonary trunk

  2. Orifice of the coronary sinus

  3. Orifice of the inferior vena cava

  4. Orifice of the superior vena cava

  5. Orifice of the tensor veli palatini


Correct Option: A
Explanation:

Orifice of pulmonary trunk is also known as the opening of pulmonary trunk in mammals. It is the opening between the pulmonary trunk and the right ventricle of the mammalian heart.

Which among the following parts of male urethra lies at the apex of the trigonum vesicae?

  1. Internal urethral orifice

  2. External urethral orifice

  3. Spongy urethra

  4. Prostatic portion of urethra

  5. Membranous part


Correct Option: A
Explanation:

The internal urethral orifice is defined as the opening of the urinary bladder into the urethra. It lies at the apex of the trigonum vesicae.

Which of the following statements does not characterise embryogenesis in human beings?

  1. The 46 chromosomes undergo changes prior to mitotic division.

  2. The zygote accomodates the combined genetic material carried by both the male and female gametes.

  3. The germinal stage takes around 10 days.

  4. Human embryology is the branch of biology, which deals with the study of the development of embryo during the first twelve weeks after fertilisation.

  5. At the onset of the ninth week, the developing embryo is known as a fetus.


Correct Option: D
Explanation:

Human embryology is the branch of biology, which deals with the study of the development of embryo during the first eight weeks after fertilisation. The normal period of gestation (pregnancy) is nine months or 38 weeks.

The membrane attack complex can be defined as a cluster of complement components that creates a pore in the plasma membrane of a cell, leading to the lysis of a cell. It mainly consists of

  1. OH

  2. Colicins

  3. C3b3b,Bb

  4. C5b,6,7,8,9

  5. Properdin


Correct Option: D
Explanation:

These terminal components form a complex which inserts into the membrane to form a transmembrane ion channel which leads to lysis of the cell.

Meissner's corpuscles are the type of mechanoreceptors present in different parts of the body. Which of the following parts of penis contains these receptors?

  1. Cumulus

  2. Acrosome

  3. Corona

  4. Head

  5. Foreskin


Correct Option: E
Explanation:

Meissner's corpuscles are the touch receptors located near the surface of the skin in human beings.The foreskin contains sensory receptors called Meissner corpuscles. These nerves provide pleasure as well as fine sensory perception.

Complement component 3 is a vital protein of the immune system of human beings. A complement component, which is strongly chemotactic for neutrophils is

  1. C9

  2. C5a

  3. C3

  4. C3b

  5. C5b


Correct Option: B
Explanation:

C5a is a powerful chemotactic agent and also an anaphylatoxin.

In biology, the acute phase proteins are the proteins whose levels fluctuate in response to tissue injury. Which of the following is not a prominent acute phase protein found in the human body?

  1. Serum amyloid P component

  2. Chondroitin sulfate

  3. C-reactive protein

  4. Mannose binding lectin

  5. Fibrinogen


Correct Option: B
Explanation:

This is a cell matrix component.

Acute inflammation is the immune response of tissues due to bodily injury. Acute inflammation can be initiated by

  1. mast cell activation

  2. influx of neutrophils

  3. an increase in vascular permeability

  4. C3

  5. lysozyme


Correct Option: A
Explanation:

Activation of mast cells releases chemotactic factors for neutrophils and also vasoactive mediators such as histamine.

In human beings, the primary lymphatic organs are the organs where lymphocytes are formed and mature. Which of the following is a primary lymphoid organ found in the body?

  1. Lymph nodes

  2. Spleen

  3. Peyer's patch

  4. Tonsil

  5. Thymus


Correct Option: E
Explanation:

T-cells are derived from bone marrow stem cells and differentiate into immunocompetent cells in the thymus.

In a human lymphatic system, the VLA molecules generally exist as

  1. homotrimers

  2. homodimers

  3. single chain molecules

  4. heterodimers with a common beta chain

  5. heterodimers with a common alpha chain


Correct Option: D
Explanation:

The alpha chain is specific for each VLA molecule (for example, VLA-1 is an alpha1beta1 molecule whilst VLA-6 is an alpha6beta1 molecule).

In a human blood, lymphocytes are small white blood cells that play a large role in defending the body against diseases. The specialised cell type involved in the entry of lymphocytes into lymph nodes are known as

  1. M cells

  2. mesangial cells

  3. PALS

  4. HEV endothelial cells

  5. selectins


Correct Option: D
Explanation:

The high-walled endothelium of the post-capillary venules (HEV) in lymph nodes express vascular addressins, which are recognised by homing receptors on lymphocytes passing through the afferent lymphatics and which mediate entry of the lymphocytes into the lymph nodes.

Which of the following is the earliest site of hematopoiesis in the developing embryo?

  1. Bone marrow

  2. Liver

  3. Yolk sac

  4. Thymus

  5. Spleen


Correct Option: C
Explanation:

Hematopoiesis originates in the early yolk sac, but as embryogenesis proceeds, this function is taken over by the fetal liver and spleen, and then later by the bone marrow, where it continues throughout life.

Which of the following diseases in the newborn is not a exposition of maternal IgG antibody crossing the placenta during third trimester?

  1. Myaesthenia gravis

  2. Butterfly rash

  3. HIV infection

  4. Thyrotoxicosis

  5. Haemolytic disease of the newborn (rhesus)


Correct Option: C
Explanation:

HIV infection is due to the transmission of the HIV virus, not the antibody. However, the presence of maternal anti-HIV IgG can lead to diagnostic difficulty. It is thus necessary to confirm HIV infection in the newborn by the presence of viral DNA or RNA using a polymerase chain reaction (PCR) method.

Which of the following structures belongs to the right atrium in a mammalian heart?

  1. Levator veli palatini

  2. Tendinous cords

  3. Orifice of the coronary sinus

  4. Trabeculae carneae

  5. Aortic orifice


Correct Option: C
Explanation:

The coronary sinus is a major coronary vein. It returns the majority of the left ventricular blood flow to the right atrium. The coronary sinus orifice of the right atrium is the aperture via which approximately 90% venous drainage of the heart is returned to the circulation by the coronary sinus.

In human beings, which of the following pregnancies carries the highest risk of adverse outcome?

  1. Singleton pregnancy

  2. Dichorionic diamniotic (DCDA) twins

  3. Monochorionic diamniotic (MCDA) twins

  4. Monochorionic monoamniotic (MCMA) twins

  5. Disappearing twin


Correct Option: D
Explanation:

Pregnancies that share the placenta and amnion are at the highest risk of adverse outcome because of risk of twin-to-twin transfusion syndrome and cord entanglement.

The first wave of fetal gamma delta T-cell receptor cells in mouse immigrates

  1. female reproductive tract

  2. skin

  3. peripheral blood

  4. thymus

  5. gut


Correct Option: B
Explanation:

Nearly all gamma delta T-cells in the skin express V gamma 5.

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