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Human Diseases (GATE)

Description: Proteins
Number of Questions: 15
Created by:
Tags: typhoid gastroenteritis haemophilus syphilis gonorrhea Bacteria
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Which of the following diagnostic tests involves the usage of cardiolipin as an antigen?

  1. TPH test

  2. FTA test

  3. VDRL (venereal disease research laboratory) test

  4. Widal test


Correct Option: C
Explanation:

VDRL test involves the usage of cardiolipin as an antigen. It is a non-specific test diagnosis of syphilis.

The tertiary stage of which of the following diseases is manifested by symptoms like paresis, tabes dorsalis or gummas?

  1. Legionnaires' disease

  2. Leptospirosis

  3. Gonorrhea

  4. Syphilis


Correct Option: D
Explanation:

Symptoms like paresis (general paralysis of insane), tabes dorsalis (damage of spinal cord and peripheral nerves) or gummas (disfiguring granulomatous lesions) are seen in the tertiary state of syphilis.

Neisseria meningitidis is the causative agent of meningococcal infections. It is transmitted by

  1. fomites

  2. water

  3. air

  4. direct contact


Correct Option: C
Explanation:

Neisseria is transmitted by airborne means. It gets transmitted from patients with active infections and from convalescent healthy carriers.

The symptoms of which of the following diseases are pain during urination and a yellowish discharge from urethra?

  1. Syphilis

  2. Gonorrhea

  3. Trichomoniasis

  4. Genital herpes


Correct Option: B
Explanation:

The symptoms of gonorrhea in males are pain during urination and a yellow discharge from the urethra. The infection in males can extend to prostate and epididymis.

Which of the following statements is true regarding enteropathogenic E. coli?

  1. It produces a heat labile toxin.

  2. It invades epithelial cells of the large intestine.

  3. It colonises jejunum and upper ileum of the small intestine.

  4. It is an opportunistic infectant, otherwise it resides on human body as normal flora.


Correct Option: C
Explanation:

Enteropathogenic E. coli colonises jejunum and upper ileum of the small intestine. It causes a moderate to severe gastroenteritis in humans and animals.

Which of the following species of Salmonella is responsible for gastroenteritis?

  1. S. paratyphi A

  2. S. typhimurium

  3. S. choleraesuis

  4. S. enteritidis


Correct Option: D
Explanation:

S. enteritidis causes gastroenteritis.

Which of the following roles are played by the shiga toxin produced by Shigella?

a. Causes fluid accumulation in intestine b. Kills various cells by inactivating the 60S subunit of eukaryotic ribosmes c. Damages walls of the blood vessels d. Causes diarrhoea

  1. a and d

  2. a and c

  3. a, b and d

  4. a, b and c


Correct Option: D
Explanation:

Shiga toxin causes fluid accumulation in the intestine, kills various cells by inactivating the 60S subunit of eukaryotic ribosomes and damages the walls of blood vessels.

Haemophilus influenzae causes which of the following diseases in older children?

  1. Influenza

  2. Epiglottitis

  3. Encephalopathy

  4. Dysentery


Correct Option: B
Explanation:

Haemophilus influenzae causes epiglottitis in older children. In this disease, epiglottis is inflamed. It gets swollen to the extent that blockage of the trachea occurs and breathing is obstructed.

Yersinia pseudotuberculosis causes

  1. plague

  2. tuberculosis

  3. gastroenteritis

  4. abdominal ulcers


Correct Option: C
Explanation:

Yersinia pseudotuberculosis causes gastroenteritis.

Which of the following agents causes typhus fever?

  1. Rickettsia prowazekii

  2. Chlamydia trachomatis

  3. Salmonella typhi

  4. Fusobacterium sps


Correct Option: A
Explanation:

Rickettsia prowazekii causes typhus fever. Its symptoms are chills, fever, headache, generalised aches, pains and exhaustion.

Which of the following organisms produces a potent exotoxin (in addition to an endotoxin) to manifest its infection?

  1. Pseudomonas aeruginosa

  2. Brucella suis

  3. Bordetella pertussis

  4. Neisseria meningitidis


Correct Option: A
Explanation:

Pseudomonas aeruginosa produces a potent exotoxin (in addition to an endotoxin) to manifest its infection. The lethal exotoxin produced is called toxin A. It has a mechanism of action identical to that of diphtheria toxin.

Which of the following types of disease is Legionnaires' disease?

  1. Encephalopathy

  2. Bronchopneumonia

  3. Septicemia

  4. Gastroenteritis


Correct Option: B
Explanation:

Legionnaires' disease is a severe bronchopneumonia. It is characterised by fever, chills and non-productive dry cough. The symptoms sometimes include chest pain, abdominal pain, vomiting, diarrhoea and mental confusion.

Which of the following strains occurs in pigs and is transmitted to humans during the processing of meat of the infected swine?

  1. Brucella melitensis

  2. Brucella abortus

  3. Brucella suis

  4. Brucella pinnipedialis


Correct Option: C
Explanation:

Brucella suis occurs in swine and is transmitted to humans during the processing of meat of the infected swine.

Campylobacter jejuni is a microaerophilic, vibrioid, Gram-negative bacterium and is often associated with

  1. abdominal ulcers

  2. gastroenteritis

  3. abdominal cramps

  4. neurological infection


Correct Option: B
Explanation:

Campylobacter jejuni is most often associated with gastroenteritis. This species produces exudative and hemorrhagic inflammation of the intestinal walls and leads to several cases of diarrhoea.

Which of the following virulence factors of Bordetella pertussis causes damage to epithelium of the respiratory tract?

  1. Adenylate cyclase toxin (CyaA)

  2. Pertussigen

  3. Heat labile toxin (HLT)

  4. Filamentous hemagglutinin (FHA)


Correct Option: C
Explanation:

Heat labile toxin (HLT) causes damage to epithelium of the respiratory tract.

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