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Antibiotics and Other Chemotherapeutic Agents (GATE ...

Description: Proteins
Number of Questions: 15
Created by:
Tags: Proteins Antibiotics Chemotherapy/Antibiotics Antifungal and Antiviral Drugs Mode of Action and Resistance
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Transmission of resistance to antibiotics takes place by R-factor which is present in the plasmids. In enteric pathogens, the transmission takes place through E. coli. Which of the following is a weak recipient of the R-factor from an E. coli donor?

  1. Klebsiella

  2. Salmonella

  3. Proteus

  4. Shigella


Correct Option: C
Explanation:

Proteus is a weak recipient of R-factor.

Nalidixic acid is used in the treatment of which of the following conditions?

  1. Tuberculosis

  2. Urinary tract infections

  3. Dermatological infections

  4. Fungal infections


Correct Option: B
Explanation:

Nalidixic acid is a synthetic chemical useful for treatment of urinary tract infections caused by gram negative bacteria. Its antimicrobial activity is attributed to inhibition of DNA synthesis.

Which of the following antibiotics acts by blocking pyridoxine and nicotinamide catalyzed reactions?

  1. Rifampicin

  2. Nitrofurantoin

  3. Ethambutol

  4. Isoniazid


Correct Option: D
Explanation:

Isoniazid acts by blocking pyridoxine and nicotinamide catalyzed reactions. It is a structural analog of pyridoxine and nicotinamide and thus, can block pyridoxine and nicotinamide catalyzed reactions.

Interferons are chemotherapeutic agents for treating viral infections. Chemically, interferons are

  1. polypeptides

  2. glycoproteins

  3. phospholipids

  4. glycolipids


Correct Option: B
Explanation:

Interferons are small glycoprotein substances made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites and also tumor cells. They are produced by RDT (Recombinant DNA Technology).

Which type of antibiotic is anthramycin?

  1. Anti-fungal antibiotic

  2. Anti-mycobacterial antibiotic

  3. Anti-tumor antibiotic

  4. Broad spectrum antibiotic


Correct Option: C
Explanation:

Anthramycin is an anti-tumor antibiotic. It works by inhibiting the synthesis of RNA and DNA of carcinoma cells.

Exposing bacterial cells to high osmotic pressure halts the activity of which antibiotic?

  1. Polymyxin

  2. Erythromycin

  3. Penicillin

  4. Sulfonamide


Correct Option: C
Explanation:

Bacterial cells susceptible to penicillin can be protected from destruction if the medium in which they are exposed is of high osmotic pressure. The high osmotic pressure prevents the cells from bursting.

Erythromycin belonging to the macrolide group manifests its action by

  1. binding to 23S rRNA component of 50S subunit of the ribosome

  2. binding to 5S rRNA component of 50S subunit of the ribosome

  3. binding to 30S subunit of 70S ribosome

  4. binding to peptidyl transferase enzyme


Correct Option: A
Explanation:

Erythromycin manifests its action by binding to 23S rRNA component of 50S subunit of the ribosome, thereby blocking the tunnel where the polypeptide string is supposed to exist.

Fosfomycin is a cell wall inhibitor. Which of the following steps of peptidoglycan synthesis is inhibited by fosfomycin?

  1. Fru 6-P to GlcN 6-P

  2. UDP-GlcNAc to UDP-MurNAc

  3. UDP-MurNAc-tripeptide to UDP-MurNAc-pentapeptide

  4. UDP-MurNAc to UDP-MurNAc-tripeptide


Correct Option: B
Explanation:

Fosfomycin inhibits conversion of UDP-GlcNAc to UDP-MurNAc. This is the first committed step in peptidoglycan biosynthesis, so amenable to selective action.

Which of the following differs from all the protein synthesis inhibitors?

  1. Kanamycin

  2. Gentamycin

  3. Lincomycin

  4. Tobramycin


Correct Option: C
Explanation:

Lincomycin belongs to lincosamide group of antibiotics. Lincomycin is an antibiotic that fights bacteria.

Which group of antibiotics binds DNA gyrase to inhibit nucleic acid synthesis?

  1. Rifamycins

  2. Quinolones

  3. Nitrofurans

  4. Antifolates


Correct Option: B
Explanation:

Quinolones bind to DNA gyrase as a topoisomerase inhibitor, thereby inhibiting synthesis of DNA.

Which of the following is a protozoal DHFR (Dihydrofolate reductase) inhibiting chemotherapeutic agent?

  1. Trimethoprim

  2. Pyrimethamine

  3. Pemetrexed

  4. Methotrexate


Correct Option: B
Explanation:

Pyrimethamine is a protozoal DHFR (Dihydrofolate reductase) inhibitor and thus, it is used as an antiprotozoal agent.

Which two organisms can be distinguished by using the antibiotic bacitracin?

  1. S. pyogenes from other beta hemolytic bacteria

  2. S. pyogenes from S. pneumoniae

  3. S. aureus from S. epidermis

  4. S. pyogenes from S. aureus


Correct Option: A
Explanation:

Bacitracin is used to distinguish S. pyogenes from other β-hemolytic streptococci because S. pyogenes is sensitive to bacitracin and other beta hemolytic bacteria are resistant.

Which of the following are susceptible to monobactams?

  1. Aerobic gram positive bacteria

  2. Anaerobic gram negative bacteria

  3. Aerobic gram negative bacteria

  4. Anaerobic gram positive bacteria


Correct Option: C
Explanation:

Monobactams work only against aerobic gram negative bacteria, e.g. Neisseria, Pseudomonas etc.

Match the following:

Antibiotic Target
1. Tomaymycin a. Virus
2. Amatadine b. Bacteria
3. Griseofulvin c. Tumor
4. Gallidermin d. Fungus
  1. 1. Tomaymycin a. Virus
    2. Amatadine c. Tumor
    3. Griseofulvin b. Bacteria
    4. Gallidermin d. Fungus
  2. 1. Tomaymycin c. Tumor
    2. Amatadine a. Virus
    3. Griseofulvin d. Fungus
    4. Gallidermin b. Bacteria
  3. 1. Tomaymycin b. Bacteria
    2. Amatadine d. Fungus
    3. Griseofulvin a. Virus
    4. Gallidermin c. Tumor
  4. 1. Tomaymycin d. Fungus
    2. Amatadine b. Bacteria
    3. Griseofulvin c. Tumor
    4. Gallidermin a. Virus

Correct Option: B
Explanation:

This is the correct match. Tomaymycin is an anti-tumor, Amatadine is an anti-viral, Griseofulvin is an anti-fungal, Gallidermin is an anti-bacterial.

Match the antibiotics with the organisms that produce them:

Antibiotic Organism
1. Chlorotetracycline a. Streptomyces noursei
2. Streptomycin b. Streptomyces aureofaciens
3. Nystatin c. Streptomyces orientalis
4. Vancomycin d. Streptomyces griseus
  1. 1. Chlorotetracycline c. Streptomyces orientalis
    2. Streptomycin a. Streptomyces noursei
    3. Nystatin b. Streptomyces aureofaciens
    4. Vancomycin d. Streptomyces griseus
  2. 1. Chlorotetracycline a. Streptomyces noursei
    2. Streptomycin c. Streptomyces orientalis
    3. Nystatin d. Streptomyces griseus
    4. Vancomycin b. Streptomyces aureofaciens
  3. 1. Chlorotetracycline b. Streptomyces aureofaciens
    2. Streptomycin d. Streptomyces griseus
    3. Nystatin a. Streptomyces noursei
    4. Vancomycin c. Streptomyces orientalis
  4. 1. Chlorotetracycline a. Streptomyces noursei
    2. Streptomycin b. Streptomyces aureofaciens
    3. Nystatin c. Streptomyces orientalis
    4. Vancomycin d. Streptomyces griseus

Correct Option: C
Explanation:

This is the correct match. Chlorotetracycline is produced by S. aureofaciens, Streptomycin is produced by S. griseus, Nystatin is produced by S. noursei and Vancomycin is produced by S. orientalis.

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