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Immune System (Medical Entrance)

Description: Proteins
Number of Questions: 15
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Tags: Proteins Immune System of Human Body Auto Immune Diseases Vaccination and Immunisation
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Level of IgG increases and decreases respectively in

  1. hyperimmunisation and Bence Jones proteinemia

  2. severe malnutrition and lymphoid aplasia

  3. IgA myeloma and chronic lymphoblastic leukemia

  4. agammaglobulinemia and rheumatoid arthritis


Correct Option: B
Explanation:

IgG level increases and decreases in severe malnutrition and lymphoid aplasia, respectively.

Hepatitis B vaccine is placed in which of the following groups?

  1. Subunit vaccine

  2. Inactivated vaccine

  3. Virus-like particle vaccine

  4. Attenuated vaccine


Correct Option: C
Explanation:

Hepatitis B vaccine is a virus-like particle based vaccine. Virus-like particle vaccines consist of viral proteins derived from the structural proteins of a virus. These proteins can self-assemble into the virus-like particles which are noninfectious as they lack viral nucleic acid.

Which of the following antibodies present in blood increases during actinomycosis?

  1. IgD

  2. IgM

  3. IgE

  4. IgA


Correct Option: B
Explanation:

Level of IgM increases during actinomycosis. Actinomycosis is an infectious bacterial disease caused by Actinomyces species.

Vaccination confers

  1. active artificial adaptive immunity

  2. passive artificial adaptive immunity

  3. active natural adaptive immunity

  4. passive natural adaptive immunity


Correct Option: A
Explanation:

Vaccination confers active artificial adaptive immunity. It is artificial because it develops through deliberate action of vaccination. It is active because immunity is induced in the host and lasts longer. It is adaptive because it is specific in action.

Which of the following types of psoriasis is characterised by raised, inflamed and reddend skin covered with silvery-white scales?

  1. Inverse psoriasis

  2. Guttate psoriasis

  3. Pustular psoriasis

  4. Plaque psoriasis


Correct Option: D
Explanation:

Plaque psoriasis causes raised, inflamed and reddend skin covered with silvery-white scales. These patches may itch and burn and may be seen on elbows, knees, scalp and lower back.

Which of the following statements is correct?

  1. Blood cells are not made in the bone marrow in autoimmune hemolytic anemia.

  2. Faulty RBC makes genes codes for red blood cells in hemolytic anemia.

  3. Premature destruction of RBC takes place in autoimmune hemolytic anemia.

  4. Fewer RBCs and less hemoglobin are made in the body in autoimmune hemolytic anemia.


Correct Option: C
Explanation:

Autoimmune hemolytic anemia (AHA) causes the premature destruction of red blood cells. It causes fatigue, pale skin, shortness of breath and dark urine. AHA is a type of acquired haemolytic anemia.

Which of the following reasons is idoneous to the purpose of artificial passive immunisation?

  1. Memory development

  2. Immediate protection

  3. Complement activation

  4. B-cell proliferation


Correct Option: B
Explanation:

Artificial passive immunisation is done for immediate protection.

Which of the following antibody levels is measured to diagnose parasitic infections?

  1. IgA antibody

  2. IgM antibody

  3. IgG antibody

  4. IgE antibody


Correct Option: D
Explanation:

IgE plays an important role in parasitic helminth diseases. Since serum IgE levels rise in parasitic diseases, measuring IgE levels is helpful in diagnosing parasitic infections.

Passive transfer of cell mediated immunity is used for the treatment of which of the following diseases?

  1. AIDS

  2. Oophoritis

  3. Cancer

  4. Tuberculosis


Correct Option: C
Explanation:

Passive transfer of cell mediated immunity is used to treat some kinds of cancer. Passive or adoptive transfer of cell-mediated immunity is conferred by the transfer of sensitised or activated T-cells from one individual into another.

Which of the following entities function(s) in hindering the passage of mother's WBC to reach the foetal side of placenta?

  1. Hofbauer cells

  2. Chorionic villi

  3. Endothelial cells

  4. Synctiotrophoblast


Correct Option: D
Explanation:

Synctiotrophoblasts are giant cells which hinder the passage of mother's WBC to reach foetal side of the placenta. If they were to reach the foetal side of the placenta, many foreign proteins will be recognised and it will trigger an immune reaction.

Immunoglobulins are divided into five different classes on which of the following bases?

  1. Amino acid sequence in the constant region of light chain

  2. Amino acid sequence in the variable region of heavy chain

  3. Amino acid sequence in the constant region of heavy chain

  4. Amino acid sequence in the variable region of light chain


Correct Option: C
Explanation:

Immunoglobulins can be divided into five different classes based on differences in the amino acid sequences in the constant region of the heavy chains. They are IgD, IgM, IgE, IgA and IgG.

Which of the following antibodies present in secretions has a T-piece associated with it?

  1. IgE antibody

  2. IgA antibody

  3. IgG antibody

  4. IgM antibody


Correct Option: B
Explanation:

When IgA is found in secretions, it has another protein associated with it. This protein is called the secretory piece or T-piece. It is the protein to which two monomeric units of IgA get conjugated.

IgD present on the surface of B-cells is anchored to the membrane with

  1. ligands

  2. amino acids

  3. vitamin-like structure

  4. prosthetic group


Correct Option: B
Explanation:

IgD present on the surface of B-cells has some extra amino acids at C-terminal end for anchoring it to the membrane.

Blocking of acetylcholine receptors at the postsynaptic neuromuscular junction by circulating antibodies causes

  1. myasthenia gravis

  2. polymyalgia rheumatica

  3. microscopic polyangiitis

  4. Behcet's syndrome


Correct Option: A
Explanation:

Myasthenia gravis or muscle weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction. It inhibits the excitatory effects of neurotransmitter acetylcholine on nicotinic receptors at neuromuscular junctions.

Which of the following conditions manifests itself in CIDP (Chronic inflammatory demyelinating polyradiculoneuropathy)?

  1. Swelling and destruction of myelin sheath over the nerves

  2. Destruction of myelin producing cells

  3. Stiffness and cramping of limbs

  4. Inflammation of the blood vessels in the brain and spinal cord


Correct Option: A
Explanation:

Swelling and destruction of myelin sheath over the nerves occurs in CIDP. Symptoms of this disease include weakness, paralysis and/or impaired movement in arms and legs.

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