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Human Respiratory System and Related Disorders (MP D...

Description: Exchange of Gases glycolysis
Number of Questions: 21
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Tags: Exchange of Gases glycolysis Breathing and Respiration
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Which of the following regulate(s) the mechanism of breathing through deepening the inhale?

  1. Peripheral chemoreceptors

  2. Central chemoreceptors

  3. Nasopulmonary and nasothoracic reflexes

  4. Spinal cord reflex

  5. Hering-Breuer reflex


Correct Option: C
Explanation:

The nasopulmonary and nasothoracic reflexes govern the mechanism of breathing through deepening the inhale. Triggered by the flow of air, the pressure of the air in the nose, and the quality of the air, impulses from the nasal mucosa are transmitted by the trigeminal nerve to the breathing centres in the brainstem and the generated response is transmitted to the bronchi, the intercostal muscles and the diaphragm.

A five year old child was diagnosed with bronchial eosinophilia. Which of the following statements about bronchial eosinophilia due to Aspergillus fumigatus is true?

  1. Patients usually have chronic asthma.

  2. Fungus is nearly always seen on the chest X-ray.

  3. Serum IgE levels are usually low or normal.

  4. Precipitating antibodies to Aspergillus fumigatus are rarely found.

  5. Eosinophils are never found in mucus plugs.


Correct Option: A
Explanation:

In contrast to pneumonic eosinophilias, which often progresses to pulmonary fibrosis, bronchial aspergillosis is present with asthma.

The lungs are among the hardest-working organs in the human body. Nerves, pulmonary vessels and bronchi in mammals enter the lungs at the

  1. base

  2. trachea

  3. mediastinum

  4. hilum

  5. apex


Correct Option: D
Explanation:

The hilum of the lung is a triangular part, which allows the other structures forming the root of the lung to enter and exit. It permits arteries, veins, nerves, bronchi and other structures to enter and exit.

Fibrosing alveolitis is characterised by inflammation, damage and progressive fibrosis of the lungs. Which of the following statements about idiopathic fibrosing alveolitis is correct?

  1. Patients are usually young.

  2. Antineutrophil cytoplasmic antibodies are positive in 90% of patients at presentation.

  3. 50% of patients die within 6 months of diagnosis.

  4. A chest X-ray can show a 'ground-glass' appearance.

  5. Lung transplantation is never effective in such patients.


Correct Option: D
Explanation:

This is a typical feature of idiopathic fibrosing alveolitis.

The abductor muscles compress the lungs during which of the following processes?

  1. Inspiration

  2. Expiration

  3. Convection

  4. Diffusion

  5. Perfusion


Correct Option: B
Explanation:

During the act of expiration, the diaphragm potentially relaxes and the elastic recoil of the lungs, chest wall and abductor muscles compresses the lungs.

In mammals, which of the following is regarded as the balance point between the inward elastic recoil of the lungs and the outward elastic recoil of the chest wall?

  1. Expiratory reserve volume

  2. Inspiratory capacity

  3. Vital capacity

  4. Total lung capacity

  5. Functional residual capacity


Correct Option: E
Explanation:

It is the volume of gas remaining in the lungs at the end of a normal tidal expiration. It is the balance point between the inward elastic recoil of the lungs and the outward elastic recoil of the chest wall.

In human beings, the pulmonary artery carries venous blood from the right ventricle of the heart to the lungs. It originates from the

  1. septomarginal trabecula

  2. conus arteriosus

  3. crista terminalis

  4. limbus of the fossa ovalis

  5. fossa ovalis


Correct Option: B
Explanation:

It is a conical extension of right ventricle in the heart of mammals from which pulmonary artery originates.

Select the correct statement regarding airways and lung alveoli.

  1. The mucus lining the upper airways is mainly produced by mucosal glands.

  2. The cartilage in the walls of trachea, bronchi and bronchioles prevents them from disrupting.

  3. The small diameter airways are the main sites of airways resistance.

  4. The upper airways play a crucial role in protecting the lungs from airborne particles.

  5. The alveoli are the only sites of gas exchange.


Correct Option: D
Explanation:

The airways epithelium play a crucial role in protecting pulmonary tissue from foreign substances by synthesising, mechanical, innate and acquired host defense systems. Airborne particles including pathogens, are absorbed by the layer of mucus lining the airways, where they are destroyed and removed through mucociliary and cough clearance.

In human beings, a negative feedback loop protects the lung from excessive hydrostatic edema via a cGMP-dependent regulation of TRPV4. Which among the following is an example of negative feedback system?

  1. Lac operon in e. coli

  2. Blood clotting

  3. Sweating

  4. Childbirth

  5. Lactation


Correct Option: C
Explanation:

When the body temperature begins to rise, a negative feedback response works to counteract and stop the rise in temperature. Thus, sweating is a suitable example of negative feedback.

In living organisms, gases like oxygen and carbon dioxide cross the plasma membrane mainly by

  1. passive diffusion through the lipid bilayer

  2. primary active transport

  3. specific gas transport proteins known as cotransporters

  4. secondary active transport

  5. proton pumps


Correct Option: A
Explanation:

Gases are non-polar and can cross the lipid bilayer with ease. They therefore, do not need specific mechanisms to cross the plasma membrane. The lipid bilayer is permeable to water molecules, oxygen and carbon dioxide. They diffuse freely in and out of the cell.

Which of the following statements regarding TCA is incorrect?

  1. The major eventual substrate of the cycle is ADP.

  2. The regulation of TCA cycle is largely determined by product inhibition and substrate availability.

  3. For each acetyl group that enters the citric acid cycle, three molecules of NADH are produced.

  4. The citrate goes through a series of chemical transformations, losing two carboxyl groups as HCO3-.

  5. In TCA, citrate is used for feedback inhibition.


Correct Option: D
Explanation:

The citrate goes through a series of chemical transformations, losing two carboxyl groups as CO2. The carbons donated by acetyl-CoA become a part of the oxaloacetate carbon backbone after the first turn of the citric acid cycle.

The respiratory quotient is a dimensionless number used to calculate the basal metabolic rate. Which of the following substances has the highest value of RQ?

  1. Oxalic acid

  2. Tartaric acid

  3. Malic acid

  4. Tripalmitin

  5. Oleic acid


Correct Option: E
Explanation:

Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is emitted by the decaying corpses of a number of insects, including bees and Pogonomyrmex ants. Its RQ value is 0.71.

Which of the following events is not involved in asthma?  

  1. Blocking activation of mast cells with a monoclonal antibody to IgE can give clinical benefit.

  2. Adrenaline is always used to reverse bronchoconstriction in mild asthmatics.

  3. Upregulation of VCAM-1 results in infiltration of eosinophils.

  4. Epithelial cell activation occurs.

  5. Activation of Th1cells occurs.


Correct Option: B
Explanation:

Adrenaline is only used in status asthmaticus and never in mild asthma.

Lung capacity is defined as the maximum air which can be held in the lungs at any given time. Which among the following has the minimum value?

  1. Alveolar air

  2. Residual air

  3. Inspiratory reserve volume

  4. Expiratory reserve volume

  5. Vital capacity


Correct Option: A
Explanation:

Alveolar air is the gas in the pulmonary alveoli, where O2-CO2 exchange with pulmonary capillary blood occurs. Some amount of air remains in the various parts of the respiratory tract. The air in the trachea and bronchi (where no diffusion occurs) is called dead space air (350 ml). The air remaining in the alveoli or air sacs is alveolar air (150 ml).

The skin prick allergy test is used to find the cause of certain allergies. Which of the following statements about skin prick testing is false?

  1. It is a useful diagnostic test for respiratory allergy.

  2. It is good for food allergy.

  3. It can cause an anaphylactic reaction.

  4. It is more reliable than specific IgE tests for hypersensitivity to an allergen.

  5. It can detect type I hypersensitivity reactions.


Correct Option: B
Explanation:

There is no reliable correlation between skin prick testing and food allergy.

Which of the following statements is correct about ventilation and gaseous exchange of mammals?

  1. Inspired air is dried in the nasal cavity.

  2. The anatomical dead space is independent of the tidal volume.

  3. In an upright lung, the alveolar ventilation is maximum at the base.

  4. The ventilation ratio for an organism in a sitting position decreases with distance above the base of the lung.

  5. The anatomical dead space is the volume of air taken in during a breath that does not enter the alveoli.


Correct Option: E
Explanation:

It is the correct statement as the dead space is the volume of air which is inhaled but does not take part in the gas exchange. It either remains in the conducting airways or reaches alveoli that are not perfused or poorly perfused.

The intrinsic laryngeal muscles are responsible for maintaining sound production in humans. The movement of which of the following muscles causes abducted vocal folds?

  1. Posterior cricoarytenoid

  2. Lateral cricoarytenoid

  3. Transverse arytenoid

  4. Oblique arytenoid

  5. Cricothyroid


Correct Option: A
Explanation:

Posterior cricoarytenoid is the ligament that passes downward from the posterior border of the arytenoid cartilage to the lamina of the cricoid cartilage. Posterior cricoarytenoid muscles abduct and externally rotate the arytenoid cartilages resulting in abducted vocal folds.

The Adam's apple is a forward protrusion of the largest cartilage of the larynx. Which of the following cartilages form(s) the Adam's apple?

  1. Cricoid cartilage

  2. Corniculate cartilages

  3. Thyroid cartilage

  4. Cuneiform cartilages

  5. Arytenoid cartilages


Correct Option: C
Explanation:

The thyroid cartilage is the largest of the laryngeal cartilages. It is formed by a right and a left lamina that are separated posteriorly. This forms the Adam's apple. It is usually larger in males than in females. The thyrohyoid membrane is a ligament associated with the thyroid cartilage that connects the thyroid cartilage with the hyoid bone.

After a complete medical checkup, the doctor told Mrs. Savita that her daughter is suffering from a genetic disease of the respiratory system in which the mucus does not clear easily from the airways. The doctor is referring to which of the following diseases?

  1. Pleural effusion

  2. Pleurisy

  3. Bronchiectasis

  4. Lymphangioleiomyomatosis (LAM)

  5. Cystic fibrosis


Correct Option: E
Explanation:

It is a genetic condition in which mucus does not clear easily from the airways. The excess mucus causes repeated episodes of bronchitis and pneumonia throughout the life.

Which of the following structures is responsible for warming and moistening the inhaled air in human beings?

  1. The laryngopharynx

  2. The oropharynx

  3. The larynx

  4. The nasopharynx

  5. The nasal cavity


Correct Option: E
Explanation:

The nasal cavity is a hollow space within the nose and skull that is lined with hairs and mucus membrane. It provides enough surface area for the inhaled air to be warmed and moistened, within fractions of a second, before reaching the lungs.

Which of the following respiratory sounds is/are caused by a narrowed or obstructed airway?

  1. Stridor

  2. Pleural rub

  3. Crackles

  4. Rhonchi

  5. Wheezing


Correct Option: A
Explanation:

Stridor is an abnormal high-pitched breathing sound that is produced from turbulent air flow in the larynx or lower in the bronchial tree. Stridor is a physical sign which is caused by a narrowed or obstructed airway.

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