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Cell Cycle and Cell Division

Description: Cell Cycle and Cell Division
Number of Questions: 34
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Tags: Cell Cycle and Cell Division Cell: Structure and Function
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Chromosomes at anaphase are of various shapes depending upon position of centromere. It is J shaped when centromere is

  1. metacentric

  2. telocentric

  3. acrocentric

  4. submetacentric


Correct Option: C
Explanation:

If the p (short) arm is so short that it is hard to observe, but still present, then the chromosome is acrocentric. The human genome includes six acrocentric chromosomes: 13, 14, 15, 21, 22 and Y chromosomes.

An egg cell has 5 pg of DNA in its nucleus. How much amount of DNA will be in this animal at the end of G2 phase mitosis?

  1. 2.5 pg

  2. 5 g

  3. 5 pg

  4. 20 pg


Correct Option: D
Explanation:

The period after DNA synthesis has occurred but prior to the start of prophase, the cell synthesizes proteins and continues to increase in size. In a gamete, DNA is n. But in other cells, it is 2n. DNA gets double after G2 phase, so it will become 4n. So, 4 x 5 pg = 20 pg. 

In wheat plant, what is the minimum number of meiotic divisions required to obtain 100 grains (fruits)?

  1. 20

  2. 100

  3. 125

  4. 200


Correct Option: C
Explanation:

Meiotic divisions are responsible for gamete formation. For wheat or any other flowering plant, it is necessary to have a pollen (4 after one meiotic division) and an egg cell (usually one after one meiotic division) to produce a single seed. To produce a single wheat grain, there should be 100 meiotic divisions to produce hundred egg cells and 25 divisions to produce 100 pollen grains.

Starting with a bacterium that divides once in half hour, how many bacteria are formed after 24 hours of growth?

  1. 212

  2. 224

  3. 248

  4. 247


Correct Option: C
Explanation:

Bacteria show mitosis and a bacteria that divides once in every half hour will result in 248 bacteria.

In Neurospora, one mitosis occurs after meiosis, and therefore, the sequence of ascospores will be

  1. 2 : 2 : 2 : 2

  2. 2 : 4 : 2

  3. both are correct

  4. both are wrong


Correct Option: C
Explanation:

In the eight-spored N. crassa, the linearly ordered ascospore pairs reflect the underlying genetic events during meiosis, and provide the clearest visual demonstration that crossing over occurs at the four-strand stage during meiotic prophase. When a gene marker is close to the centromere (no crossing over between the gene and centromere), the two alleles are likely to segregate from one another at the first division of meiosis and result in a 4:4 ascospore pattern for the segregating alleles. In contrast, when a gene marker is far from the centromere (cross over likely) the two alleles often segregate at the second division of meiosis show a 2:2:2:2 or 2:4:2 ascosporepattern for the segregating alleles.

If a bacterial cell divides every minute, it takes 59 minutes to fill one half of the cup. How much time would it take to fill the full cup?

  1. 30 minutes

  2. 59 minutes

  3. 60 minutes

  4. 1 minute


Correct Option: C
Explanation:

In 60 minutes the full cup will be filled. It is a known fact that when a bacteria divides by binary fission, it doubles itself in number. So, after the cup is half full, 1 more binary fission is required to fill the whole cup, as each bacteria in the half-filled cup is going to undergo binary fission and double itself.

In animal cells, cytokinesis occurs by cleavage method. To divide a cell into two, the cell membrane grows

  1. centripetally

  2. centrifugally

  3. aseptically

  4. gravitationally


Correct Option: A
Explanation:

Cytokinesis, during which the cell cytoplasm divides to form two daughter cells, begins during telophase of mitosis. It occurs differently in plant and animal cells. In animal cells, cytokinesis is accomplished by cleavage, the division or splitting of the cell cytoplasm. Cleavage begins with the formation of a cleavage furrow in the region of the metaphase plate.

Nuclear membrane disappears at late prophase and reappears at the end of telophase. From where do these nuclear membranes arise?

  1. From cytoplasm of the cell

  2. From nucleus of the cell

  3. From ER and old nuclear membrane pieces

  4. From NOR


Correct Option: C
Explanation:

During mitosis, the nuclear envelope merges with the endoplasmic reticulum (ER), and nuclear pore complexes are disassembled. In a current model for reassembly after mitosis, the nuclear envelope forms by a reshaping of ER tubules.

Crossing over during meiosis occurs at 4 – strand stage called Pachytene stage. This was proved by which of the following observations?

  1. Chiasmata occurs at 4 strand stage.

  2. All 4 gametes show recombinations.

  3. Mostly 2 gametes out of 4 formed meiosis are recombinants.

  4. All are correct


Correct Option: C
Explanation:

Chromosomal crossover (or crossing over) is the exchange of genetic material between homologous chromosomes that results in recombinant chromosomes. It is one of the final phases of genetic recombination, which occurs during prophase I of meiosis(pachytene) in a process called synapsis. Synapsis begins before the synaptonemal complex develops, and is not completed until near the end of prophase I. Crossover usually occurs when matching regions on matching chromosomes break and then reconnect to the other chromosome.

Which sequence of events during cell division is the most accurate?

  1. DNA replication, karyokinesis, cytokinesis

  2. Karyokinesis, cytokinesis, DNA duplication

  3. Cytokinesis, karyokinesis, DNA duplication

  4. None of the above


Correct Option: A
Explanation:

Cell division involves the distribution of identical genetic material, DNA, to two daughters cells. The sequence of events during cell division is: DNA replication, Karyokinesis, Cytokinesis.

Metaphase I is characterized by orientation of bivalents where

  1. limbs of chromosomes lie at equator and centromeres towards poles

  2. limbs lie towards poles and centromeres at equator

  3. limbs and poles both lie towards poles

  4. limbs and poles both lie at equator


Correct Option: A
Explanation:

In mitosis: The centrioles are at opposite poles of the cell. The pairs of homologous chromosomes (the bivalents), now as tightly coiled and condensed as they will be in meiosis, become arranged on a plane equidistant from the poles called the metaphase plate. Spindle fibers from one pole of the cell attach to one chromosome of each pair (seen as sister chromatids), and spindle fibers from the opposite pole attach to the homologous chromosome (again, seen as sister chromatids).

Which of the following is a wrong statement about mitosis?

  1. Prophase is of the longest duration.

  2. During anaphase, centromere moves first.

  3. In interphase, no metabolic activity occurs.

  4. Chromosomes are spirally coiled.


Correct Option: C
Explanation:

Interphase occurs when the cell is not undergoing mitosis. It engages in metabolic activity. DNA duplicates during the synthesis phase of interphase to prepare for mitosis. 

When a diploid cell undergoes normal meiotic division, what will probably happen?

  1. Dominant genes will segregate into daughter cells.

  2. Homologous chromosomes of a pair separate.

  3. All daughter cells will have different homologous chromosome pairs.

  4. All linkage groups will be disrupted.


Correct Option: B
Explanation:

The process in cell division in sexually reproducing organisms that reduces the number of chromosomes from diploid to haploid (half the original number). Meiosis involves two consecutive divisions of the nucleus and leads to the production of reproductive cells (gametes) in animals and to the formation of spores in plants, fungi, and most algae (the haploid spores grow into organisms that produce gametes by mitosis).

Which among the following is true for phragmoplast?

  1. Proplastid is cytoplasm of dividing cell.

  2. Cell plates are formed by vesicles of ER and dictyosomes during cytokinesis.

  3. Cell plate is formed by ER, dictyosomes, secretory vesicles and spindle fibres.

  4. None of the above


Correct Option: C
Explanation:

The phragmoplast is a plant cell specific structure that forms during late cytokinesis. It serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall separating the two daughter cells. The phragmoplast is a complex assembly of microtubules (MTs), microfilaments (MFs), and endoplasmic reticulum (ER) elements, that assemble in two opposing sets perpendicular to the plane of the future cell plate during anaphase and telophase. It is initially barrel-shaped and forms from the mitotic spindle between the two daughter nuclei, while nuclear envelopes reassemble around them.

In meiosis I, a bivalent is an association of

  1. four chromatids and four centromeres

  2. four chromatids and two centromeres

  3. two chromatids and two centromeres

  4. two chromatids and one centromeres


Correct Option: B
Explanation:

Meiosis is the process by which replicated chromosomes undergo two nuclear divisions to produce four haploid cells, also called meiocytes (sperms and eggs). Diploid (2n) organisms rely on meiosis to produce meiocytes, which have half the ploidy of the parents, for sexual reproduction. Halving the ploidy in meiocytes is essential for restoring the genetic content of the zygote to that of the parents. Meiosis uses similar mechanisms as those employed during mitosis to accomplish the separation and redistribution of chromosomes. However, several features, namely pairing and genetic recombination between homologous chromosomes, are unique to meiosis.

Thread like structures that start to appear from each centromere by the end of prophase are

  1. kinetochore microtubules

  2. polar microtubules

  3. aster microtubules

  4. spindle microtubules


Correct Option: A
Explanation:

The kinetochore is the protein structure on chromatids, where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore forms in eukaryotes, assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis.

A cell with 2n = 16 undergoes meiosis. Each of the four daughter nuclei formed at the end of the division will have

  1. 4 chromosomes – double stranded

  2. 8 chromosomes – single stranded

  3. 8 chromosomes – double stranded

  4. 4 chromosomes – single stranded


Correct Option: B
Explanation:

A cell with 2n = 16 undergoes meiosis. Each of the four daughter nuclei formed at the end of the division will have single stranded 8 chromosomes.

At diakinesis, a meiocyte has ten pairs of chromosomes. The number of chromosomes expected in each nucleus, is therefore,

  1. ten at the end of I division and five at the end of II division

  2. ten at the end of I division ant ten at the end of second division

  3. five at the end of I division and five at the end of second division

  4. twenty at the end of I division and ten at the end of second division


Correct Option: B
Explanation:

At diakinesis, a meiocyte has ten pairs of chromosomes. The number of chromosomes expected in each nucleus is, therefore ten at the end of I division ant ten at the end of second division. 

The sequence of substages of prophase I is

  1. Leptotene – Zygotene – Pachytene – Diplotene – Diakinesis

  2. Leptotene – Zygotene – Pachytene – Diakinesis – Diplotene

  3. Leptotene – Zygotene – Pachytene – Diakinesis

  4. Leptotene – Pachytene – Diplotene – Zygotene – Diakinesis


Correct Option: A
Explanation:

Prophase I has so many processes happening that it is usually separated into five stages. They are listed, in order, below with their explanations. Leptonema During this stage, the chromosomes begin to condense and become visible. Zygonema The chromosomes continue to become denser. The homologous pairs have also found each other and begin to initially align with one another, referred to as 'rough pairing'. Pachynema Coiling and shortening continues as the chromosomes become more condense. A synapsis forms between the pairs, forming a tetrad. Diplonema The sister chromatids begin to separate slightly, revealing points of the chiasma. This is where genetic exchange occurs between two non-sister chromatids, a process known as crossing over. Diakinesis The chromosomes continue to pull apart, but non-sister chromatids are still loosely associated via the chiasma. The chiasma begin to move toward the ends of the tetrad as separation continues. This process is known as terminalization. Also during diakinesis, the nuclear envelope breaks down and the spindle fibers begin to interact with the tetrad.

During fertilization, two cells fuse but the blastomeres formed from the division of the zygote contain the same number of chromosomes as the body cells because

  1. meiosis occurs during cleavage

  2. sperm-chromosomes are completely lost

  3. meiosis occurs during gametogenesis

  4. arrhenotoky occurs during gametogenesis


Correct Option: C
Explanation:

During fertilization, two cells fuse but the blastomeres formed from the division of the zygote contain the same number of chromosomes as the body cells because meiosis occurs during gametogenesis.

What is a disk of protein that serves as an attachment site for the microtubules of mitotic apparatus called?

  1. Kinetochore

  2. Centromere

  3. Chromomere

  4. Chromatid


Correct Option: A
Explanation:

The kinetochore is the protein structure on chromatids, where the spindle fibers attach during cell division to pull sister chromatids apart. The kinetochore forms in eukaryotes, assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis.

Which among the following is true for congression?

  1. Pairing of homologous chromosomes.

  2. Separation of paired chromosomes.

  3. Bringing the chromosomes on equator of spindle apparatus.

  4. Movement of sister chromatids towards the poles.


Correct Option: C
Explanation:

In prometaphase, once the nuclear envelope has broken down, the spindle microtubules and the chromosomes are no longer separated by a (double) membrane boundary. The microtubules begin to interact with the chromosomes, and the chromosomes undergo what is known as congressional movement, where they ultimately end up with their centromeres all situated in middle of the spindle, at a site known as the metaphase plate. Each kinetochore of the replicated chromosome is pointed towards one side of the spindle; later, in anaphase, each kinetochore moves to one of the two spindle pole regions as the daughter chromosome. The congression of chromosomes and the alignment of centromeres on the metaphase plate represent essential prerequisites for the orderly separation of the replicated genome into two equal parts. The mechanisms underlying congression are under intense scrutiny.

Choose the incorrect one.

  1. Pachytene – Crossing over

  2. Chiasmata – Diplotene

  3. Replication – S-phase

  4. Phragmoplast – Cell membrane


Correct Option: D
Explanation:

The phragmoplast is a plant cell specific structure that forms during late cytokinesis. It serves as a scaffold for cell plate assembly and subsequent formation of a new cell wall, separating the two daughter cells.

When a dividing cell is treated with hydrogen peroxide, the spindle fibres precipitate due to formation of disulphide bridges. This reaction indicates that the spindle fibres and the microtubules are which of the following structures?

  1. Glycosyl structures

  2. Proteinaceous structures

  3. Non-polar organic structures

  4. None of the above


Correct Option: B
Explanation:

When a dividing cell is treated with hydrogen peroxide, the spindle fibres precipitate due to formation of disulphide bridges. This reaction indicates that the spindle fibres and the microtubules are proteinaceous structures.

If a somatic cell undergoes two successive nuclear divisions without cytokinesis, the resultant will have

  1. 2 diploid nuclei

  2. 4 diploid nuclei

  3. 4 haploid nuclei

  4. 2 haploid nuclei


Correct Option: B

During meiosis, cross over occurs between which of the following?

  1. Non-sister chromatids of homologous chromosomes

  2. Sister chromatids of homologous chromosomes

  3. Sister chromatids of non-homologous chromosomes

  4. Non-sister chromatids or non-homologous chromosomes.


Correct Option: A

Which of the following statements is not true about interphase?

  1. DNA doubles itself.

  2. Depletion of stored energy is there.

  3. Chromosomes strung out in the form of chromatin threads.

  4. Cells build up a sufficiently large store of energy.


Correct Option: B
Explanation:

Interphase is the phase of the cell cycle in which the cell spends the majority of its time and performs the majority of its purposes including preparation for cell division. In preparation for cell division, it increases its size and makes a copy of its DNA, which is made during the S-phase. Interphase is also considered to be the 'living' phase of the cell, in which the cell obtains nutrients, grows, reads its DNA, and conducts other "normal" cell functions. The majority of eukaryotic cells spend most of their time in interphase. Interphase does not describe a cell that is merely resting but is rather an active preparation for cell division.

In a meiotic cell division, two homologus chromosomes finish the division in the same daughter nucleus. Which among the following can be associated with this statement?

  1. Mutation

  2. Polyploidy

  3. Non-disjunction of chromosomes

  4. Endoduplicaton


Correct Option: C
Explanation:

Non-disjunction is the failure of chromosome pairs to separate properly during meiosis stage 1 or stage 2, specifically in the anaphase. This could arise from a failure of homologous chromosomes to separate in meiosis I or the failure of sister chromatids to separate during meiosis II or mitosis. The result of this error is a cell with an imbalance of chromosomes. Such a cell is said to be aneuploidy.

What happens in a somatic cell cycle?

  1. G2 phase follows motitic phase.

  2. DNA replication takes place in S-phase.

  3. A short interphase is followed by a long motitic phase.

  4. In G1 phase, DNA constent is double the amount of DNA present in the original cell.


Correct Option: B
Explanation:

In a somatic cell cycle, DNA replication takes place in S-phase. G2 phase follows interphase. Mitotic phase is a relatively short period of the cell cycle and in interphase, DNA content is doubled. 

Which of the following precedes reformation of the nuclear envelope during M-phase of the cell cycle?

  1. Transcription from chromosomes and reassembly of the nuclear lamina

  2. Decondensation from chromosomes and reassembly of the nuclear lamina

  3. Formation of the contractile ring and transcription from chromosomes

  4. Formation of the contractile ring and formation of the phragmoplast


Correct Option: B

Cyclin protein is required for cell cycle. Which other molecule is essential for completion of cell cycle?

  1. CCk

  2. CKc

  3. CdK

  4. CKd


Correct Option: C

Name the stage of cell cycle at which the following events occurs.

  1. Chromosomes are moved to spindle equator.
  2. Centromere splits and chromatids separate.
  3. Pairing between homologous chromosomes takes place.
  4. Crossing over between homologous chromosomes takes place.
    1. Anaphase, 2. Metaphase, 3. Zygotene, 4. Pachytene
    1. Anaphase, 2. Pachytene, 3. Zygotene, 4. Metaphase
    1. Metaphase, 2. Anaphase, 3. Zygotene, 4. Pachytene
    1. Anaphase, 2. Metaphase, 3. Pachytene, 4. Zygotene

Correct Option: A
Explanation:
  1. Anaphase  -Chromosomes are moved to spindle equator.
    1. Metaphase -Centromere splits and chromatids separate.
    2. Zygotene -Pairing between homologous chromosomes takes place.
    3. Pachytene -Crossing over between homologous chromosomes takes place.

Brachymeiosis is a characteristic of ascomycetous fungi. It involves

  1. two reductional and one equational division

  2. two reductional and two equational division

  3. one reductional and two equational division

  4. one reductional and one equational division


Correct Option: A

Mitotic cell cycle is divided into 4 phases G1, S, G2 and M. Considering a mitotic cycle time of 18 hours, the distribution of period of time for each of these phases will be

  1. G1-1 S-3 G2-5 M-9

  2. G1-9 S-1 G2-3 M-5

  3. G1-9 S-5 G2-3 M-1

  4. G1-3 S-5 G2-9 M-1


Correct Option: C
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