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Essential and Non-Essential Amino Acids (GATE )

Description: MBA Management
Number of Questions: 15
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Tags: GAte Essential Amino Acids and Fatty Acids
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Which of the following amino acids are both glucogenic and ketogenic?

  1. Glycine
  2. Phenylalanine
  3. Threonine
  4. Proline
  5. Tryptophan
  1. 1, 2 and 4

  2. 1, 4 and 5

  3. 2, 3 and 4

  4. 2, 3 and 5

  5. 3, 4 and 5


Correct Option: D
Explanation:

Phenylalanine, threonine and tryptophan all are glucogenic as well as ketogenic amino acids.

Which of the following statements are true regarding transamination?

P. Transamination means transfer of amide nitrogen from a donor molecule to an acceptor molecule. Q. Liver is the main site for transamination. R. Transamination reactions are irreversible. S. Transamination reactions are catalysed by aminotransferases.

  1. P and Q

  2. P and R

  3. P and S

  4. Q and R

  5. Q and S


Correct Option: E
Explanation:

This option is correct because liver is the main site for transamination and transamination reactions are catalysed by aminotransferases (transaminases).

For the identification of which of the following entities is Sanger’s reagent?

  1. N-terminal of a peptide chain

  2. C-terminal of a peptide chain

  3. Side chain of amino acid

  4. Molecular weight of the peptide chain

  5. Number of amino acids in the peptide chain


Correct Option: A
Explanation:

This option is correct because Sanger’s reagent is use for determining the N-terminal amino acid in peptide chains, in particular insulin.

Which among the following are glucogenic intermediates?

  1. Pyruvate
  2. α-ketoglutarate
  3. Succinyl-CoA
  4. Fumarate
  5. Oxaloacetate
  6. Acetyl-CoA
  7. Acetoacetate
  1. 1, 2, 3 and 4

  2. 1, 3, 5 and 7

  3. 2, 3 4 and 5

  4. 3, 4, 5 and 6

  5. 4, 5, 6 and 7


Correct Option: C
Explanation:

α-ketoglutarate, Succinyl-CoA, Fumarate and Oxaloacetate all are glucogenic intermediates (form glucose).

Which of the following is/are example(s) of anaerobic dehydrogenases?

  1. LAAO
  2. DAAO
  3. GLDH
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: C
Explanation:

Glutamate dehydrogenase (GLDH) is an anaerobic dehydrogenase.

Desulfhydrase deaminates

  1. cystine
  2. serine
  3. threonine
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: A
Explanation:

Desulfhydrase deaminates sulphur-containing amino acids, e.g. cysteine and cystine.

Which of the following amino acids can act as metabolic precursor for synthesis of methionine and lysine?

  1. Aspartate

  2. Glutamate

  3. Phenylalanine

  4. Serine

  5. Threonine


Correct Option: A
Explanation:

Aspartate acts as metabolic precursor to asparagine, methionine, threonine and lysine.

Which of the following enzymes need pyrindoxal phosphate as coenzyme?

P. D-amino acid oxidase Q. Dehydratase R. Desulfhydrase S. Glutamate dehydrogenase

  1. P and Q

  2. P and R

  3. P and S

  4. Q and R

  5. Q and S


Correct Option: D
Explanation:

Both dehydratase and desulfhydrase need pyrindoxal phosphate as coenzyme.

Which of the following amino acids acts as precursor to hormones epinephrine, norepinephrine and dopamine?

  1. Tyrosine

  2. Threonine

  3. Tryptophan

  4. Proline

  5. None of these


Correct Option: A
Explanation:

In dopaminergic cells in the brain, tyrosine is converted to L-DOPA by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can then be converted into norepinephrine and epinephrine.

Which of the following is a pair of non-protein amino acids?

  1. Ornithine and Citrulline

  2. Glycine and Tyrosine

  3. Valine and Arginine

  4. Ornithine and Tyrosine

  5. Arginine and Citrulline


Correct Option: A
Explanation:

Ornithine and Citrulline are non-protein amino acids.

Which of the following is a pair of exclusively ketogenic amino acids?

  1. Leucine and Isoleucine

  2. Leucine and Lysine

  3. Lysine and Tyrosine

  4. Isoleucine and Lysine

  5. Leucine and Tyrosine


Correct Option: B
Explanation:

A significant amount of metabolic energy can come from amino acid metabolism, particularly under conditions of starvation. Amino acids that are metabolized to produce acetyl-CoA and acetoacetate are called ketogenic amino acids. In humans, two amino acids are exclusively ketogenic: Leucine and Lysine.

Which of the following tests is used in identification of tyrosine?

  1. Xanthoproteic reaction

  2. Millon’s test

  3. Hopkins-Cole test

  4. Edman’s reaction

  5. Hippuric acid test


Correct Option: B
Explanation:

Millon’s test is for identification of tyrosine.

Which of the following amino acids undergo(es) phosphorylation?

  1. Serine
  2. Threonine
  3. Proline
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: D
Explanation:

Both serine and threonine have -OH groups; so they can undergo phosphorylation.

Match the following amino acids with their metabolic precursors and select the correct option.

 
Amino acid Metabolic precursor
A. Alanine 1. α-ketoglutarate
B. Glutamine 2. Pyruvate
C. Histidine 3. 3-phosphoglycerate
D. Serine 4. Ribose 5-phosphate
  1. A - 4, B - 3, C - 2, D - 1

  2. A - 2, B - 1, C - 3, D - 4

  3. A - 2, B - 1, C - 4, D - 3

  4. A - 3, B - 2, C - 4, D - 1

  5. A - 1, B - 2, C - 3, D - 4


Correct Option: C
Explanation:

Alanine is most commonly produced by reductive amination of pyruvate. α-ketoglutarate (also known as oxoglutarate) is a precursor to glutamine. Ribose 5-phosphate is a key precursor to histidine. Glycerate 3-phosphate is a precursor to serine.

Match the following:

 
Column – I Column – II
P. Xanthoproteic reaction 1. Identification of 2-Amino-3-(1H-indol-3-yl)propanoic acid
Q. Edman’s reaction 2. Determination of the amino acid sequence of a protein
R. Millon’s test 3. Identification of L-2-Amino-3-(4-hydroxyphenyl)propanoic acid
S. Hopkins-Cole test 4. Detection of aromatic amino acids
  1. P – 1, Q – 3, R – 2, S – 4

  2. P – 1, Q – 2, R – 4, S – 3

  3. P – 2, Q – 1, R – 4, S – 3

  4. P – 4, Q – 2, R – 3, S – 1

  5. P – 4, Q – 3, R – 2, S – 1


Correct Option: D
Explanation:

Aromatic amino acids can be detected by Xanthoproteic reaction. Edman’s reaction can be used to determine the amino acid sequence of a protein. Millon’s test is for identification of L-2-Amino-3-(4-hydroxyphenyl)propanoic acid. Hopkins-Cole test is for identification of 2-Amino-3-(1H-indol-3-yl)propanoic acid.

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