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Human Diseases (LPU)

Description: bacterial control three Tuberculosis Tetanus Syphilis Veneral disease
Number of Questions: 20
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Tags: bacterial control three Tuberculosis Tetanus Syphilis Veneral disease Infectious Diseases AIDS and Cancer: Causes and Control
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Oncogenic virus are capable of causing cancer. An example of known oncogenic virus is

  1. Herpes zoster

  2. HIV-2

  3. Epstein-Barr virus

  4. Vesicular stomatitis virus

  5. Proteus mirabilis


Correct Option: C
Explanation:

Epstein-Barr virus is associated with Burkitt's lymphoma and with naso-pharyngeal carcinoma.

Cholera bacillus is a bacterial species that produces a soluble exotoxin and causes cholera in humans. Who among the following scientists is credited with the first production of live, but non-virulent forms of chicken cholera bacillus?

  1. Pasteur

  2. Salk

  3. Jenner

  4. Montague

  5. Sabin


Correct Option: A
Explanation:

A culture of chicken cholera bacillus accidentally left on bench during warm summer months lost much of its ability to cause disease, but could protect birds from the effects of fresh virulent bacillus. Pasteur also obtained similar results for anthrax and rabies.

Primary immunodeficiency producing susceptibility to infection by viruses and molds is due to which of the following deficiencies?

  1. B-cell deficiency

  2. T-cell deficiency

  3. Phagocyte deficiency

  4. Complement deficiency

  5. Eosinophil deficiency


Correct Option: B
Explanation:

Production of cytokines and of cytotoxic T-cells is important in the protective response.

Which of the following diseases has been completely eradicated worldwide?

  1. Measles

  2. Smallpox

  3. Tuberculosis

  4. Cowpox

  5. Psittacosis


Correct Option: B
Explanation:

The eradication of smallpox was due to an enormous World Health Organization (WHO) sponsored effort combining extensive vaccination and selective epidemiologic control methods.

Dead Wuchereria bancrofti can cause which of the following diseases in human beings?

  1. Elephantiasis

  2. Erythema nodosum leprosum

  3. Serum sickness

  4. Pigeon fancier's disease

  5. Farmer's lung


Correct Option: A
Explanation:

Dead filarial worm parasites in lymphatic vessels initiate an inflammatory reaction thought to be responsible for obstruction of the flow of lymph.

BCG is used for protection against which of the following diseases?

  1. Rabies

  2. Tuberculosis

  3. Hepatitis B

  4. Influenza

  5. Pertussis


Correct Option: B
Explanation:

Bacille Calmette Guérin (BCG) was developed by Calmette and Guérin by chance in 1908 at the Institute Pasteur in Lille. They added bile to the culture medium in an attempt to achieve dispersed growth of Mycobacterium tuberculosis, but it became attenuated and successfully protected vaccinated children against tuberculosis. 

Which of the following is a distinguished feature of a Salmonella-based vaccine manifesting antigens from other infectious agents?

  1. Immunity is limited to the gut.

  2. Only secretory IgA is elicited.

  3. It does not invade the mucosal lining of the gut.

  4. It provokes both oral and systemic immunity.

  5. The organism does not need to be attenuated.


Correct Option: D
Explanation:

Salmonella infects cells of the mononuclear phagocyte system throughout the body and thereby, stimulates the production of cell-mediated immunity in addition to both secretory and systemic antibody production.

Which of the following is/are a proven route of transmission of HIV?

  1. Swimming pools

  2. Mosquitoes

  3. Shared bathroom facilities

  4. Semen

  5. Bed bugs


Correct Option: D
Explanation:

This is the correct answer as HIV can be transmitted sexually.

Among the following, select the one way through which HIV cannot be transmitted.

  1. Across the placenta

  2. Sharing needles

  3. Breast feeding

  4. Sexual intercourse

  5. Sharing toothbrushes


Correct Option: E
Explanation:

This has been proven not to transmit HIV, but is not recommended on general health grounds.

Western blots are primarily used to detect which of the following molecules?

  1. Proteins

  2. Carbohydrates

  3. Lipids

  4. RNA

  5. DNA


Correct Option: A
Explanation:

Following separation by techniques such as SDS-PAGE or isoelectric focussing, proteins can be blotted by transverse electrophoresis onto polyvinylidene difluoride (PVDF) or nitrocellulose membranes and then, identified by staining with appropriately labelled antibodies.

Which of the following does not protect body surface from bacteria?

  1. Skin

  2. Mucus

  3. Gastric acid

  4. Salivary amylase

  5. Gut microflora


Correct Option: D
Explanation:

This enzyme splits starch and is of importance for digestion, but not for protection.

Which of the following clinical features is NOT usually associated with HIV infection?

  1. A glandular fever-like illness

  2. Persistent generalised lymphadenopathy

  3. Gonococcal septicaemia

  4. Slim disease

  5. Presenile dementia


Correct Option: C
Explanation:

Unusual in HIV (except at a late stage when any infection is possible); more often associated with complement deficiencies.

Intracellular parasites including roundworm and tapeworm within macrophages are killed more readily in the presence of which of the following?

  1. Antibodies

  2. Kinins

  3. Properdin

  4. Gamma-interferon

  5. Anaphylatoxin


Correct Option: D
Explanation:

Gamma-interferon activates microbicidal mechanisms within the macrophage, thereby leading to the death of intracellular parasites.

Baculovirus vectors can be produced in cell lines derived from which of the following?

  1. Chicken bursa

  2. Chinese hamster ovary

  3. Tobacco

  4. Green monkey kidney

  5. Moth


Correct Option: E
Explanation:

Baculovirus vectors in moth cell lines produce large amounts of glycosylated recombinant protein. The baculovirus is a natural infectious agent of insect cells.

Protection against microorganisms inside cells is generally provided by

  1. T-cells

  2. antibodies

  3. platelets

  4. red blood cells

  5. antigens


Correct Option: A
Explanation:

T-lymphocytes are specialised for recognising peptides derived from intracellular infectious agents which are exhibited on the surface of an infected cell together with MHC class I and II molecules.

Which of the following is most pertinent to healthy individuals with selective IgA deficiency?

  1.  All individuals can be considered to be normal without risk of infections.

  2. They are more likely to develop heart disease than those with normal IgA levels.

  3. They will always have a high risk of HIV infection.

  4. They have a high risk of a recurrent serious bacterial infection.

  5. They have a higher risk of developing an organ specific autoimmune disease or allergies than the general population.


Correct Option: E
Explanation:

These individuals have a higher risk of developing an organ specific autoimmune disease or allergies than the general population.

Specific immunity to M. tuberculosis in human beings is provided by

  1. B-cells

  2. T-cells

  3. macrophages

  4. neutrophils

  5. IgG


Correct Option: B
Explanation:

T-cells are important for immunity to M. tuberculosis through the provision of Th1 cytokines.

The spleen is an important organ for keeping bodily fluids balanced. It is largely involved with response to antigens, which are located in

  1. tissues

  2. blood

  3. gut

  4. lungs

  5. urogenital tract


Correct Option: B
Explanation:

The spleen can be thought of as a filter sampling the blood for red cells and foreign antigens.

Which of the following bacteria is able to escape from phagocytic vacuoles in the cells?

  1. Haemophilus influenzae

  2. Bacillus anthracis

  3. Vibrio cholerae

  4. Neisseria

  5. Listeria monocytogenes


Correct Option: E
Explanation:

Listeria monocytogenes is able to escape from phagocytic vacuoles and survive in the cytoplasm of phagocytic cells.

IgE levels are high in infections with

  1. Trichinella spiralis

  2. Trypanosoma cruzi

  3. Trypanosoma rhodesiense

  4. Plasmodium falciparum

  5. Leishmania tropica


Correct Option: A
Explanation:

Parasites like Trichinella frequently increase the IgE levels, usually polyclonally. This tends to inhibit the protective effect of IgE by diluting out the specific IgE on the mast cell. Inflammation induced by mast cell degranulation leads to influx of IgG, which causes damage to the parasite.

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