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CSIR Life Sciences

Description: CSIR UGC NET Lifesciences Life Sciences
Number of Questions: 15
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Tags: CSIR UGC NET Lifesciences Life Sciences
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Portion of antibody which binds with antigen is

  1. epitope

  2. paratope

  3. hapten

  4. active site

  5. none of the above

Show answer
Correct Option: B
Explanation:

Paratope is the portion of antibody, which binds with antigen.

Which of the following is an immunogen?

  1. Penicillin

  2. Progesterone

  3. Aspirin

  4. Insulin

  5. None of the above

Show answer
Correct Option: D
Explanation:

Molecular weight of insulin is more than 1000 daltons. So, it is immunogenic.

Autoimmune response against thyroglobulin and thyroid peroxidase is seen in

  1. Grave's disease

  2. Hashimoto's thyroiditis

  3. Myasthania gravis

  4. Both 1 and 2

  5. Both 2 and 3

Show answer
Correct Option: B
Explanation:

Hashimotos thyroiditis is due to TSH stimulation-blocking antibody, which blocks activation of TSH hormone and subsequently bring damage and atrophy of thyroid gland.

Huntington disease is caused by

  1. increased number of trinucleotide gene repeats (CAG)

  2. mutation in gene for the protein cystic fibrosis trans-membrane conductance regulator or CFTR

  3. deficiency of the protein α1-anti-trypsin or A1-AT

  4. formation of insoluble amyloid protein

  5. none of the above

Show answer
Correct Option: A
Explanation:

Huntington disease is caused by increased number of trinucleotide gene repeats (CAG) leading to increased number of glutamine residues incorporated incorresponding protein.

Mad cow disease is due to

  1. virions

  2. prions

  3. bacteria

  4. fungus

  5. none of the above

Show answer
Correct Option: B
Explanation:

Mad cow disease is caused by a misfolded protein called prions.

Warmest period during cenozoic era was

  1. eocene epoch

  2. pleistocene epoch

  3. pliocene epoch

  4. oligocene epoch

  5. paleocene epoch

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Correct Option: A
Explanation:

Eocene epoch was the warmest period during cenozoic era.

Birefrigerence is used in which microscopy technique?

  1. Polarised light microscopy

  2. Confocal scanning light microscopy

  3. Flourescence microscopy

  4. Phase contrast microscopy

  5. None of the above

Show answer
Correct Option: A
Explanation:

Birefrigerence is an optical activity. An object manifest birefrigerence by appearing bright when placed between two polarising filters oriented with their respective plane of transmission perpendicular to one another.

Which of the following processes is a substrate level phosphorylation?

  1. Transfer of phosphoryl group from substrate to ADP

  2. Transfer of phosphoryl group from ATP to substrate

  3. Addition of phosphoryl group to nucleoside to form nucleotide

  4. Only 1 and 2

  5. All of the above

Show answer
Correct Option: A
Explanation:

Transfer of phosphoryl group from substrate to ADP (Adenosine di nucleotide) result the formation of ATP (Adenosine trinucleotide) is called substrate level phosphorylation.

In citric acid cycle, when succinate is converted to fumarate, the hydrogen atom is received by

  1. ADP

  2. GDP

  3. NAD

  4. FAD

  5. O2

Show answer
Correct Option: D
Explanation:

FAD receives hydrogen from succcinate.

The membrane bound enzyme involved in citric acid cycle is

  1. aconitase

  2. fumarase

  3. succinate dehydrogenase complex

  4. malate dehydrogenase

  5. alpha-ketoglutarate dehydrogenase

Show answer
Correct Option: C
Explanation:

Succinate dehydrogenase complex is the only membrane bound enzyme involved in citric acid cycle.

In which step is GTP produced in citric acid cycle?

  1. Convertion of alpha-keto glutarate to succinyl CoA

  2. Convertion of isocitrate to oxalosuccinate

  3. Conversion of succinyl CoA to succinate

  4. Conversion of succinate to fumarate

  5. Conversion of malate to oxaloacetate

Show answer
Correct Option: C
Explanation:

In this step, GTP is formed.

A sample contains a mixture of proteins having approximately similar molecular masses. A particular protein of the sample tagged with histidine can be separated by which of the following techniques?

  1. Gel filtration chromatography

  2. Nickel affinity chromatography

  3. Ion exchange chromatography

  4. Affinity chromatography using Glutathion S-transferase

  5. All of the above

Show answer
Correct Option: B
Explanation:

Affinity chromatography using Nickel can be used to separate protein tagged by histidine.

The important enzyme involved in regulation of glycolysis is

  1. phosphoglucoisomerase

  2. enolase

  3. pyruvate kinase.

  4. phosphoglycerate kinase

  5. phosphofructose kinase

Show answer
Correct Option: E
Explanation:

This enzyme converts fructose 6-phosphate to fructose 1,6-bisphosphate. This is an important enzyme involved in regulation of glycolysis.

Which of the following enzymes does not use Magnesium (Mg2+) cofactor?

  1. Phosphoglycerate kinase

  2. Glyceraldehyde phosphate dehydrogenase

  3. Phosphoglucoisomerase

  4. Phosphofructokinase

  5. Hexokinase

Show answer
Correct Option: B
Explanation:

This enzyme converts glyceraldehyde 3-phosphate to 1, 3-bisphosphoglycerate. Mg2+ is not required for this enzyme.

An example of aldol condensation is

  1. convertion of phosphoglycerate to phosphoenolpyruvate

  2. convertion of phosphoenolpyruvate to pyruvate

  3. convertion of acetyl CoA to citrate

  4. convertion of isocitrate to alpha ketoglutarate

  5. none of the above

Show answer
Correct Option: C
Explanation:

Condensation of acetyl CoA with oxaloacetate leads to the formation of citrate, which invoves the change in convertion of keto group of oxaloacetate to aldol form. This is known as aldol condensation.

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