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Human Physiology (UPCAT)

Description: circulatory system renal system
Number of Questions: 25
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Tags: circulatory system renal system Human Physiology
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Which of the following is the most important risk factor in the aetiology of intraventricular haemorrhage in preterm infants?

  1. Coagulation disorder

  2. Intermittent positive-pressure ventilation

  3. Pneumothorax

  4. Extreme prematurity

  5. Hypoxic–ischaemic encephalopathy


Correct Option: D
Explanation:

Prematurity is the most important risk factor, with IVH being very rare in term infants.

Regarding the human kidneys, which among the following statements is false?

  1. The renal cortex lies outside the medulla.

  2. The right kidney lies lower than the left kidney.

  3. The renal veins drain directly into the inferior vena cava.

  4. The link between the kidney and the bladder is the urethra.

  5. The renal cortex contains all the glomeruli.


Correct Option: D
Explanation:

The link between the kidneys and the bladder is the ureter. The urethra drains urine out of the bladder.

A couple got blessed with a baby boy. But unfortunately, the baby fell victim of physiological jaundice. Which of the following is the major contributor to the development of physiological jaundice?

  1. Breastfeeding

  2. Decreased hepatic bilirubin excretion

  3. Immature hepatic enzymes

  4. Enterohepatic circulation

  5. Increased bilirubin production


Correct Option: E
Explanation:

The major cause of physiological jaundice is increased bilirubin production due to increased haemoglobin levels at birth and a shortened red cell lifespan.

A particular type of cells responsible for the entry of lymphocytes into lymph nodes are known as

  1. M-cells

  2. Selectins

  3. PALS

  4. HEV endothelial cells

  5. Mesangial cells


Correct Option: B
Explanation:

Selectins are a family of molecules, not cells. l-selectin is involved in the entry of lymphocytes into lymph nodes and is the lymphocyte homing receptor, which recognises the high endothelial venule (HEV) addressin molecule.

Antibody opsonisation is the process by which a pathogen is identified for ingestion and eliminated by a phagocyte. Opsonisation of bacteria occurs through coating bacteria with which of the following receptors?

  1. C3b

  2. C8

  3. Membrane attack complex

  4. F(ab')2 IgG

  5. IgM


Correct Option: A
Explanation:

There are receptors for C3b on the surface of phagocytic cells.

Considering the glomerular filtration, which among the following statements is true?

  1. The main site of glomerular filtration is the loop of Henle.

  2. Bowman's capsule surrounds the perinephric fat.

  3. The filtration barrier contains three layers of cells.

  4. Constriction of the afferent arterioles increases filtration.

  5. Small molecules are more easily filtered than large molecules.


Correct Option: E
Explanation:

Glomerular filtration of molecules depends on their size and their charge. Small molecules are filtered more because they pass through the filtration barrier more easily than large molecules.

Mycoplasma pneumoniae infection can lead to which of the following diseases?

  1. Hashimoto's thyroiditis

  2. Agranulocytosis

  3. Cold hemagglutinin disease

  4. Thrombocytopenic purpura

  5. Neonatal alloimmune thrombocytopenia


Correct Option: C
Explanation:

Patients with cold hemagglutinin disease have monoclonal anti-blood group I, leading to an autoimmune hemolytic anemia. It consists of warm-, cold- or mixed-reactive antibody types that are directed against antigens on the red blood cell surface. Mycoplasma pneumoniae infection can cause cold hemagglutinin disease.

Maple bark stripper's disease mainly affects the lumber workers employed in stripping the bark from maple logs. It is a hypersensitivity mainly affecting the

  1. skin

  2. kidneys

  3. nervous system

  4. lungs

  5. blood


Correct Option: D
Explanation:

Maple bark stripper's disease is a type III extrinsic allergic alveolitis due to continual inhalation of Cryptostroma spores, which induce high antibody levels.

Which of the following does NOT predispose to superficial Candida albicans infection?

  1. Pregnancy

  2. Lymphoma

  3. Diabetes mellitus

  4. Vegetarian diet

  5. Broad-spectrum antibiotics


Correct Option: D
Explanation:

There is no evidence that this leads to excess Candida infections or to poor nutrition.

Which of the following cells are thought NOT to be of monocyte-macrophage lineage?

  1. Neutrophils

  2. Follicular dendritic cells of lymph nodes

  3. Kupffer cells in liver

  4. Histiocytes in tissues

  5. Monocytes in blood


Correct Option: A
Explanation:

These are of the myeloid lineage.

In the thymic medulla, the majority of gamma delta T-cells are

  1. CD4+CD8+

  2. CD4+CD8–

  3. CD4–CD8+

  4. CD4–CD8–

  5. surface Ig+


Correct Option: D
Explanation:

By far, the vast majority of gamma delta T-cells are 'double negative' CD4–CD8–.

Immunoglobulin E (IgE) is a prominent antibody being found in minute amounts in the body and plays a crucial role in allergic diseases. Which of the following types of cells produce IgE?

  1. Mast cells

  2. Eosinophils

  3. Basophils

  4. T lymphocytes

  5. Plasma cells


Correct Option: E
Explanation:

Plasma cells produce immunoglobulins of all isotypes, including IgE.

IgG antibodies are very important in fighting bacterial and viral infections. Which among the following statements regarding IgG antibodies is incorrect?

  1. They appear early in the primary immune response.

  2. They neutralise bacterial toxins.

  3. They can fix complement.

  4. They cross the human placenta.

  5. They protect body surfaces that are exposed to foreign substances.


Correct Option: A
Explanation:

IgM is the class which appears early following the first encounter with a specific antigen.

Which of the following cell types are phagocytic?

  1. Hepatocytes

  2. Lymphocytes

  3. Monocytes

  4. Erythrocytes

  5. Plasma cells


Correct Option: C
Explanation:

They are circulating immature macrophages or dendritic cells.

The lining wall of the alimentary canal appears different in different parts of the gut, reflecting different roles, but always has the same basic layers. Which among the following layers prevents food from traveling backward?

  1. The muscularis externa

  2. The gastric mucosa

  3. The submucosa

  4. The serosa

  5. The oral mucosa


Correct Option: A
Explanation:

The muscularis externa consists of an inner circular layer and a longitudinal outer muscular layer.

Neutrophil chemotaxis is mediated by which among the following molecules?

  1. C5b

  2. IL-8

  3. C3a

  4. CCL2

  5. E-selectin


Correct Option: B
Explanation:

IL-8 produced by endothelial cells later in the inflammatory response is a powerful chemotactic agent for neutrophils.

Absorption of the maximum of the nutrients takes place in the jejunum, with the following notable exceptions. Among these, which is absorbed by facilitated diffusion in small intestine?

  1. Vitamin B12

  2. Iron

  3. Lipids

  4. Sodium bicarbonate

  5. Fructose


Correct Option: E
Explanation:

Fructose is the natural simplest sugar found in fruits and vegetables.

Which of the following agents is NOT immunosuppressive?

  1. Levamisole

  2. Corticosteroids

  3. Thalidomide

  4. Aspirin

  5. Total lymphoid irradiation


Correct Option: D
Explanation:

This is an anti-inflammatory drug. 

Most cases of acute laukaemia in children are of which of the following types?

  1. T-cell ALL

  2. Mature B-cell ALL

  3. Hairy cell laukaemia

  4. Pre-B-cell ALL

  5. Histiocytic laukaemia


Correct Option: D
Explanation:

64% of ALL are the pre-B-cell type.

The human immunodeficiency virus interacts with which of the following cell-surface molecules to gain entry into cells of the immune system of the body?

  1. CD19

  2. CD4

  3. CD40 ligand

  4. CD8

  5. CD25


Correct Option: B
Explanation:

This is a major portal of entry, though not the only one. 

Which of the following mast cell products is not accomplished and therefore, has to be newly formed?

  1. Histamine

  2. Prostaglandin D2

  3. Heparin

  4. Neutral protease

  5. Eosinophil chemotactic factor (ECF)


Correct Option: B
Explanation:

Prostaglandins and thromboxanes are newly synthesised by mast cells using the cyclo-oxygenase pathway. The leukotrienes B4, C4 and D4 (slow reacting substance of anaphylaxis, SRS-A) are also newly synthesised by the mast cell in this instance using the lipoxygenase pathway.

In human beings, P-selectin is the transmembrane glycoprotein of -140 kDa. It usually pairs with

  1. LFA-3

  2. LFA-1

  3. ICAM-1

  4. Sialyl Lewisx

  5. Beta2 integrin molecules


Correct Option: D
Explanation:

P-selectin is a lectin that binds the Sialyl Lewisx carbohydrate determinants on the mucin-like PSGL-1 (P-selectin glycoprotein ligand-1).

Which among the following type of body cells are NOT phagocytic in nature?

  1. Neutrophil polymorphonuclear leucocytes

  2. B lymphocytes

  3. Microglial cells

  4. Macrophages

  5. Kupffer cells


Correct Option: B
Explanation:

B lymphocytes secrete antibodies and cytokines and are responsible for antigen-specific humoral responses. 

In human beings, Hassall's corpuscles are generally found in

  1. peripheral blood

  2. bone marrow

  3. spleen

  4. thymus

  5. Peyer's patches


Correct Option: D
Explanation:

Whorled aggregates of epithelial cells form these highly characteristic structures found in the thymus. They serve as a disposal system for dying thymocytes.

In which part of the alimentary canal are some of the water and electrolytes removed from the food?

  1. In the large intestine

  2. In the small intestine

  3. In the stomach

  4. In the oesophagus

  5. In the mouth


Correct Option: A
Explanation:

After passing via the small intestine, food reaches into the large intestine, where some of the water and electrolytes, mainly sodium, are removed from the food. 

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