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Antibodies (Level : Hard)

Description: Proteins
Number of Questions: 22
Created by:
Tags: Antibodies Immune System Immune System of Human Body
Attempted 0/22 Correct 0 Score 0

IgG protects the body from infections by several mechanisms, except

  1. agglutination

  2. opsonisation

  3. precipitation

  4. neutralisation


Correct Option: C
Explanation:

IgG does not cause precipitation.

Which is the most abundant antibody in human body?

  1. IgM

  2. IgG

  3. IgA

  4. IgE


Correct Option: B
Explanation:

IgG is the most abundant antibody in the human body. 

Which antibody is administered to neutralise the effect of snake and scorpion venom?

  1. IgD

  2. IgM

  3. IgA

  4. IgG


Correct Option: D
Explanation:

IgG is used to neutralise snake and scorpion venom.

Which is the first antibody to appear in response to antigens in humans?

  1. IgG

  2. IgM

  3. IgA

  4. IgD


Correct Option: B
Explanation:

IgM is the first antibody to appear in response to initial exposure to an antigen.

Which is the only antibody that can pass through placenta?

  1. IgA

  2. IgG

  3. IgM

  4. IgD


Correct Option: B
Explanation:

IgG can pass through placenta and confer passive resistance to the foetus.

Which activity is common to both IgM and IgA?

  1. Complement fixation activity

  2. Agglutination activity

  3. Neutralisation activity

  4. Opsonisation activity


Correct Option: B
Explanation:

IgM and IgA both have agglutination activity.

Which antibodies activate complement?

  1. IgE and IgA

  2. IgG and IgM

  3. IgG and IgA

  4. IgM and IgA


Correct Option: B
Explanation:

IgG and IgM activate complement.

The concentration of IgD is low in serum because

  1. IgD is highly unstable

  2. IgD is membrane bound

  3. IgD is produced in minuscule amounts

  4. IgD is an intracellular antibody


Correct Option: B
Explanation:

IgD is a membrane bound immunoglobulin, because of which there is lesser concentration of IgD in serum.

In mucosal system, IgA exists as

  1. monomer

  2. dimer

  3. trimer

  4. pentamer


Correct Option: B
Explanation:

In mucosal system, IgA exists as a dimer.

The half-life of IgE immunoglobulin increases to 2 weeks if IgE molecules bind to

  1. basophills

  2. plasma cells

  3. mast cells

  4. T-cells


Correct Option: C
Explanation:

The half life of IgE immunoglobulins increases to 2 weeks if IgE molecules bind to mast cells.

The IgM of teleost fish is a

  1. pentamer

  2. hexamer

  3. tetramer

  4. trimer


Correct Option: C
Explanation:

Teleost IgM is a tetrameric molecule.

Which antibody is effective against parasitic infections?

  1. IgD

  2. IgE

  3. IgM

  4. IgA


Correct Option: B
Explanation:

IgE antibody is effective against parasitic infections.

Which of the following conditions results in complete lack of antibodies?

  1. Multiple sclerosis

  2. x-Linked agammaglobulinemia

  3. Haemolytic anaemia

  4. x-Linked hypophosphatemia


Correct Option: B
Explanation:

x-Linked agammaglobulinemia is a rare X-linked genetic disorder which manifests as a complete lack of antibodies in bloodstream.

Which antibody is produced in spleen?

  1. IgG

  2. IgA

  3. IgM

  4. IgE


Correct Option: C
Explanation:

The spleen where plasmablasts responsible for antibody production reside is the major site of specific IgM production.

In which of the following disorders does IgE level increase?

  1. Congenital rubella

  2. Rheumatoid arthritis

  3. Celiac disease

  4. Pneumonia


Correct Option: B
Explanation:

IgE level increases in rheumatoid arthritis.

IgY antibody is found in

  1. mammals

  2. chondrichthyes

  3. teleost fish

  4. birds


Correct Option: D
Explanation:

All birds have IgY antibody.

Which type of proteins are antibodies?

  1. Albumins

  2. Heptaglobin

  3. Glycoproteins

  4. Fibrinogens


Correct Option: C
Explanation:

Antibodies are glycoproteins.

The Fc region of antibody which gives the ability to an antibody to communicate with the other components of the immune system contains

  1. conserved phosphorylation site

  2. conserved glycosylation site

  3. conserved adenylation site

  4. conserved C-mannosylation site


Correct Option: B
Explanation:

The Fc region of antibody which gives the ability to an antibody to communicate with the other components of the immune system contains conserved glycosylation site.

What is the part of an antibody which recognises an antigen called?

  1. Epitope

  2. Paratope

  3. Mimotope

  4. Idiotype


Correct Option: B
Explanation:

The part of antibody which recognises an antigen is called paratope. It is a small portion of variable region of antibody that contains both heavy and light chains

Match the columns:

 
Immunoglobulin Molecular weight (in KD)
1.IgG a. 200
2. IgM b. 165
3. IgA c. 900
4. IgE d. 150
  1.  
    1. IgG c. 900 KD
    2. IgM d. 150 KD
    3. IgA a. 200 KD
    4. IgE b. 165 KD
  2.  
    1. IgG a. 200 KD
    2. IgM d. 150 KD
    3. IgA c. 900 KD
    4. IgE b. 165 KD
  3.  
    1. IgG b. 165 KD
    2. IgM c. 900 KD
    3. IgA a. 200 KD
    4. IgE d. 150 KD
  4.  
    1. IgG d.150 KD
    2. IgM c. 900 KD
    3. IgA b. 165 KD
    4. IgE a. 200 KD

Correct Option: D
Explanation:

This is the correct match.

Which isotype is expressed on the surface of immature B-cells?

  1. IgA+

  2. IgG+

  3. IgM+

  4. IgE+


Correct Option: B
Explanation:

IgG+ isotype is expressed on the surface of immature B-cells.

Match the columns ||| |---|---| |Immunoglobulin |Half-life (days)| |1. IgG|a. 5| |2. IgM|b. 5.5| |3. IgA|c. 2| |4. IgE|d. 23|

  1. 1. IgG c. 2 days
    2. IgM b.5.5 days
    3. IgA d. 23 days
    4. IgE a. 5 days
  2. 1. IgG a. 5 days
    2. IgM d. 23 days
    3. IgA c. 2 days
    4. IgE b. 5.5 days
  3. 1. IgG d. 23 days
    2. IgM a.5 days
    3. IgA b. 5.5 days
    4. IgE c. 2 days
  4. 1. IgG b. 5.5 days
    2. IgM a. 5 days
    3. IgA d. 23 days
    4.IgE c. 5.5 days

Correct Option: C
Explanation:

This is the correct match.

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