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Amino Acids (GATE)

Description: GAte
Number of Questions: 15
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Tags: GAte Essential Amino Acids and Fatty Acids
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Which of the following amino acids acts as precursor to hormones epinephrine, norepinephrine and dopamine?

  1. L-2-Amino-3-(4-hydroxyphenyl)propanoic acid

  2. 2-Amino-3-hydroxybutanoic acid

  3. (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

  4. Pyrrolidine-2-carboxylic acid

  5. 2-Amino-3-phenylpropanoic acid


Correct Option: A
Explanation:

In dopaminergic cells in the brain, tyrosine (L-2-Amino-3-(4-hydroxyphenyl)propanoic acid) is converted to l-dopa by the enzyme tyrosine hydroxylase (TH). TH is the rate-limiting enzyme involved in the synthesis of the neurotransmitter dopamine. Dopamine can be converted into norepinephrine and epinephrine.

Which of the following acts as metabolic precursor to amino acid aspartate?

  1. Pyruvate

  2. Oxaloacetate

  3. Ribose 5-phosphate

  4. α-Ketoglutarate

  5. 3-Phosphoglycerate


Correct Option: B
Explanation:

Correct answer. Oxaloacetate acts as metabolic precursor to aspartate.

Which of the following amino acids are both glucogenic and ketogenic?

  1. Glycine
  2. Phenylalanine
  3. Threonine
  4. Proline
  5. Tryptophan
  1. 1, 2 and 4

  2. 1, 4 and 5

  3. 2, 3 and 4

  4. 2, 3 and 5

  5. 3, 4 and 5


Correct Option: D
Explanation:

Correct answer. Phenylalanine, threonine and tryptophan are glucogenic as well as ketogenic amino acids.

Desufhydrase deaminates

  1. cystine
  2. serine
  3. threonine
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: A
Explanation:

Correct answer. Desufhydrase deaminates sulphur containing amino acids, e.g. cysteine.

Which of the following are non-essential amino acids?

  1. 2-Amino-4-methylpentanoic acid
  2. Pyrrolidine-2-carboxylic acid
  3. 2-Aminopropanoic acid
  4. 2-Amino-3-phenylpropanoic acid
  5. 2-amino-3-methylbutanoic acid
  6. L-2-Amino-3-(4-hydroxyphenyl)propanoic acid
  1. 1, 2 and 5

  2. 1, 3 and 6

  3. 2, 4 and 5

  4. 2, 3 and 6

  5. 3, 4 and 5


Correct Option: D
Explanation:

Correct answer

Which of the following statements are not correct regarding transamination?

P. Transamination means transfer of amide nitrogen from a donor molecule to a acceptor molecule. Q. Liver is the main site for transamination. R. Transamination reactions are irreversible. S. Transamination reactions are catalysed by aminotransferases.

  1. P and Q

  2. P and R

  3. P and S

  4. Q and R

  5. Q and S


Correct Option: B
Explanation:

Correct answer

Which of the following is/are anaerobic dehydrogenase(s)?

  1. L-amino acid oxidase
  2. D-amino acid oxidase
  3. Glutamate dehydrogenase
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: C
Explanation:

Correct answer. Glutamate dehydrogenase is an anaerobic dehydrogenase.

Which of the following enzymes needs pyrindoxal phosphate as coenzyme?

P. D-amino acid oxidase Q. Dehydratase R. Desulfhydrase S. Glutamate dehydrogenase

  1. P and Q

  2. P and R

  3. P and S

  4. Q and R

  5. Q and S


Correct Option: D
Explanation:

Both dehydratase and desulfhydrase need pyrindoxal phosphate as coenzyme.

Which of the following amino acids can act as metabolic precursor for synthesis of HO2CCH(NH2)CH2SH and NH2CH2COOH?

  1. Aspartate

  2. Glutamate

  3. Phenylalanine

  4. Serine

  5. Threonine


Correct Option: D
Explanation:

Correct answer. Glycerate 3-phosphate acts as a precursor for serine.

Which of the following is a pair of exclusively ketogenic amino acids?

  1. Leucine and isoleucine

  2. Leucine and Lysine

  3. Lysine and tyrosine

  4. Isoleucine and lysine

  5. Leucine and tyrosine


Correct Option: B
Explanation:

Correct answer

Which of the following amino acids in proteins undergo(es) phosphorylation?

  1. 2-Amino-3-hydroxypropanoic acid
  2. 2-Amino-3-hydroxybutanoic acid
  3. Pyrrolidine-2-carboxylic acid
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: D
Explanation:

Correct answer. Both amino acids undergo phosphorylation.

Match the following:

 
Column – I
Column – II
A. Alanine 1. α-ketoglutarate
B. Glutamine 2. Pyruvate
C. Histidine 3. 3-phosphoglycerate
D. Serine 4. Ribose 5-phosphate
  1. A - 4, B - 3, C - 2, D - 1

  2. A - 2, B - 1, C - 3, D - 4

  3. A - 2, B - 1, C - 4, D - 3

  4. A - 3, B - 2, C - 4, D - 1

  5. A - 1, B - 2, C - 3, D - 4


Correct Option: C
Explanation:

Correct matching is A - 2, B - 1, C - 4, D - 3.

Match the following:

 
Column – I Column – II
A. Glutamine 1. K
B. Lysine 2. Q
C. Tryptophan 3. W
D. Tyrosine 4. Y
  1. A - 3, B - 4, C - 2, D - 1

  2. A - 2, B - 1, C - 3, D - 4

  3. A - 2, B - 3, C - 1, D - 4

  4. A - 3, B - 2, C - 1, D - 4

  5. A - 3, B - 1, C - 4, D - 2


Correct Option: B
Explanation:

Correct answer

Match the following:

 
Column – I Column – II
P. Xanthoproteic reaction 1. Identification of tryptophan
Q. Edman’s reaction 2. Determination of the amino acid sequence of a protein
R. Millon’s test 3. Identification of tyrosine
S. Hopkins-Cole test 4. Detection of aromatic amino acids
  1. P – 1, Q – 2, R – 3, S – 4

  2. P – 1, Q – 2, R – 4, S – 3

  3. P – 2, Q – 1, R – 4, S – 3

  4. P – 4, Q – 2, R – 3, S – 1

  5. P – 4, Q – 3, R – 2, S – 1


Correct Option: D
Explanation:

Correct answer

Which of the following sets represents essential amino acids?

  1. Tryptophan, Histidine, Aspartic acid, Proline, Leucine

  2. Valine, Leucine, Tryptophan, Lysine, Histidine

  3. Alanine, Proline, Aspartic acid, Glycine, Cysteine

  4. Valine, Leucine, Aspartic acid, Glycine, Cysteine

  5. Alanine, Valine, Lysine, Glycine, Tryptophan


Correct Option: B
Explanation:

Correct answer 

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