Question 1

The biosynthesis of heme requires all of the following except

propionic acid
succinyl CoA
glycine
ferrous ion

Answer

Correct Option: A

Question 2

What is true about aminolevulinic acid synthase?

It requires NAD for its activity.
It is allosterically activated by heme.
Its synthesis is inhibited by steroids.
Its synthesis can be induced by drugs.

Answer

Correct Option: D

Question 3

What is true about Ferrochelatase?

It is an iron chelating agent.
It releases iron from heme in the degradation of Hb.
It binds iron to sulfide ions and cysteine.
Its activity is inhibited by heavy metals.

Answer

Correct Option: D

Question 4

Lead poisoning would be expected to result in an elevated level of

aminolevulinic acid
porphobilinogen
biliverdin
heme

Answer

Correct Option: A

Question 5

Which of the following substances gets mainly elevated in the blood of a person suffering from cholangiocarcinoma?

Direct bilirubin
Indirect bilirubin
Both direct and indirect bilirubin
Heme but not bilirubin

Answer

Correct Option: A

Question 6

Heme oxygenase

can oxidize methene bridge between three pyrrole rings of heme
requires molecular oxygen for its activity
produces bilirubin and carbon dioxide
can use protoporphyrin as substrate

Answer

Correct Option: A

Question 7

The substance deposited on skin and sclera in jaundice is

biliverdin
only unconjugated bilirubin
only direct bilirubin
both bilirubin and bilirubin diglucuronide

Answer

Correct Option: D

Question 8

Acute intermittent porphyria is accompanied by increased urinary

biliverdin
direct bilirubin
heme
porphobilinogen

Answer

Correct Option: D

Question 9

What is the true condition about Dubin Johnson syndrome?

UDP glucuronyl transferase is deficient
UDP glucuronyl transferase is absent
Uptake by liver is defective
Transport into the biliary system is defective

Answer

Correct Option: D

Question 10

Which of the following porphyria is associated with chemicals and drugs and occurs due to defect in the uroporphyrinogen decarboxylase?

Variegate porphyria
Porphyria cutanea tarda
Acute Intermittent porphyria
Erythropoietic protoporphyria

Answer

Correct Option: B

Question 11

Which of the following statements is true?

HbS is caused by a single base mutation on the beta-chain.
Fluorescent probes may assist in the diagnosis of haemoglobinopathies.
In thalassaemia, persistance of HbF is an adverse prognostic sign.
In Alpha thalassaemia, there is a deficiency of beta-chain production.

Answer

Correct Option: A

Question 12

High serum alkaline phosphatase in a person having jaundice indicates

hepatic carcinoma
gall stones
hemolytic anemia
pancreatitis

Answer

Correct Option: B

Question 13

All the following regarding the metabolism of bilirubin are correct except

urobilinogen is synthesized in the intestine
unconjugated bilirubin is lipophilic
bilirubin diglucuronide is synthesized in liver
bilirubin is excreted in normal urine

Answer

Correct Option: D

Question 14

Which of the enzymes are not present in mitochondria?

Ferrochelatase
Coproporphyrinogen oxidase
Protoporphyrinogen oxidase
ALA dehydratase

Answer

Correct Option: D

Question 15

What is suggested for a 52-year-old black woman, who is supplimented on iron and vitamin C for many years, when she was told that her RBC count has never completely normalized, O/E and other parameters are normal and Hb = 11.6 g/dL?

Continue iron therapy
Discontinue iron therapy
Hb electrophoresis
Blood transfusions

Answer

Correct Option: B

Question 16

Acute intermittent porphyria is due to defect in

uroporphyrinogen III cosynthase
porphobilinogen deaminase
protoporphyrinogen oxidase
coproporphyrinogen oxidase

Answer

Correct Option: B

Question 17

In erythroid cells, which of the following enzymes regulates heme synthesis?

ALA synthase
ALA dehydratase
Protoporphyrinogen oxidase
Ferrochelatase

Answer

Correct Option: D

Question 18

Microcytic hypochromic anemia is seen in all except

thalassemia
iron deficiency anemia
malaria
lead poisoning

Answer

Correct Option: C

Question 19

Patients with sickle cell anemia are prone to infections with

staphylococcus
streptococcus
gonococcus
pneumococcus

Answer

Correct Option: D

Question 20

Which of the following is not a feature of acute intermittent porphyria?

Abdominal pain
Neuropsychiatric
Photosensitivity
Urine darkens on standing

Answer

Correct Option: C

Question 21

The protective effect against malaria is related to

HbF
HbH
HbS
HbM

Answer

Correct Option: C

Question 22

Biphasic reaction in Vandenbergh test is seen in which of following conditions?

Viral hepatitis
Spherocytosis
Carcinoma of head of the pancreas
Stones in the bile ducts

Answer

Correct Option: A

Question 23

Hydrops foetalis is due to the defect in the synthesis of

Alfa-globin chain
Beta-globin chain
Delta-globin chain
Gamma-globin chain

Answer

Correct Option: A

Question 24

A young patient has total bilirubin- 26 mg/dl, direct bilirubin- 14 mg/dl, ALP- 158 mg/dL. Bile salts and pigments are present in urine, while urobilinogen is absent. The jaundice in this case is

Hepatic
Hemolytic
Obstructive
None of these

Answer

Correct Option: C

Question 25

Which of the following is true in a normal person?

AST/ALT > 1
AST/ALT > 2
AST/ALT< 1
ALT/AST < 1

Answer

Correct Option: C

Description: This test is useful to prepare Heme,Porphyria, Jaundice, Biosynthesis, Proteins, Vitamins, Antibiotics
Number of Questions: 25
Created by: Mohini Tyagi
Tags: Heme Porphyria Jaundice Biosynthesis Proteins Vitamins Antibiotics

Heme Metabolism

Find more quizzes from top tags