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Immunology (GATE)

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Which among the following protein complexes enhances Follicle-stimulating hormone, biosynthesis and secretion, and participates in the regulation of the menstrual cycle?

  1. Hyalin

  2. Inhibin

  3. Bindin

  4. Avidin

  5. Activin


Correct Option: E
Explanation:

Activin is a protein complex which enhances Follicle-stimulating hormone biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair and endocrine function.

Which among the following parts of an antibody is recognised as an antigenic determinant?

  1. Mimotope

  2. Allergen

  3. Immunogen

  4. Paratope

  5. Hapten


Correct Option: D
Explanation:

An epitope, also known as antigenic determinant, is the part of an antigen that is recognised by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that recognises the epitope is called a paratope.

_____________ is a confining the enzyme molecules to a distinct phase from the one in which the substrates and the products are present.

  1. Electropermeabilisation

  2. Zymography

  3. Enzyme assays

  4. Enzyme immobilisation

  5. Enzymology


Correct Option: D
Explanation:

Enzyme immobilisation may be defined as confining the enzyme molecules to a distinct phase from the one in which the substrates and the products are present.

Which one of the following is not correctly matched?

  1. Agglutination : Cross linkage of antigens by antibodies

  2. Hybridoma : Revealing intra-specific variation and diversity between species

  3. Plant tissue culture technique : Selection of somaclones that are resistant to herbicides

  4. RNA interference : Biological process in which RNA molecules inhibit gene expression

  5. Photolithography : Transferring geometric shapes on a mask to the surface of a silicon wafer


Correct Option: B
Explanation:

This option is correct because Hybridoma technology is a technology of forming hybrid cell lines by fusing an antibody-producing B cell with a myeloma (B cell cancer) cell that is selected for its ability to grow in tissue culture and for an absence of antibody chain synthesis and revealing intra-specific variation and diversity between species is a Random Amplified Polymorphic DNA (RAPD).

Classification Determinant-8 (CD8) is a transmembrane glycoprotein present in:

  1. Cytotoxic T lymphocyte
  2. Th cells
  3. Regulatory T cell
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: C
Explanation:

Classification Determinant-8 is a transmembrane glycoprotein present in Regulatory T cell.

Which one of the following RNA molecules is involved in the regulation of gene expression?

  1. miRNA

  2. gRNA

  3. scaRNA

  4. snoRNA

  5. rRNA


Correct Option: A
Explanation:

A microRNA (miRNA) is a small non-coding RNA molecule found in plants, animals and some viruses, which functions in transcriptional and post-transcriptional regulation of gene expression.

Which among the following is/are peripheral lymphoid organs?

  1. Peyer's patches
  2. Mucosa-associated lymphoid tissue
  3. Bone marrow
  4. Adenoids
  5. Thymus
  1. 1 and 2

  2. 1, 2 and 4

  3. 2 and 3

  4. 3, 4 and 5

  5. 4 and 5


Correct Option: B
Explanation:

This option is correct because Peyer's patches, mucosa-associated lymphoid tissue and adenoids are peripheral lymphoid organs.

Which of the following terms refers to PCD?

  1. Anoikis
  2. Entosis
  3. Necrosis
  4. Apoptosis
  1. 1 and 2

  2. 1 and 4

  3. 2 and 3

  4. 2 and 4

  5. 3 and 4


Correct Option: B
Explanation:

This option is correct because apoptosis is the process of programmed cell death that may occur in multicellular organisms where biochemical events lead to characteristic changes in morphology of cell and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation and chromosomal DNA fragmentation. Anoikis is a form of programmed cell death which is induced by anchorage-dependent cells detaching from the surrounding extracellular matrix.

Which of the following is/are sex-linked recessive disease(s)?

I. Hemophilia II. Drepanocytosis III. Phenylketonuria

  1. Only I

  2. Only II

  3. Only III

  4. I and II

  5. II and III


Correct Option: A
Explanation:

Hemophilia is a sex-linked recessive disease, which shows its transmission from an unaffected carrier female to some of the male progeny.

Which of the following is a carbohydrate binding protein?

  1. Claudin

  2. Lectin

  3. Ghrelin

  4. Integrin

  5. Leptin


Correct Option: B
Explanation:

Lectins are carbohydrate-binding protein macromolecules that are highly specific for sugar moieties.

Statins produced by which of the following microbes are commercialised as blood-cholesterol lowering agents?

  1. Saccharomyces cerevisiae

  2. Trichoderma polysporum

  3. Clostridium acetobutylicum

  4. Monascus purpureus

  5. Aspergillus niger


Correct Option: D
Explanation:

Statins produced by the yeast Monascus purpureus have been commercialised as blood-cholesterol lowering agents. It acts by competitively inhibiting the enzyme responsible for synthesis of cholesterol.

Assertion: In capping, methyl guanosine triphosphate is added to the 5'-end of hnRNA. Reason: In tailing, adenylate residues are added at 3'-end in a template independent manner.

In the following question, there are two statements, Assertion (A) and Reason (R), consider both the statements independently and mark your answers as given under:

1. A and R both are correct, and R is correct explanation of A.
2. A and R both are correct, and R is not correct explanation of A.
3. A is correct and R is incorrect.
4. A is incorrect and R is correct.
5. A and R both are incorrect.

  1. A and R both are correct and R is the correct explanation of A.

  2. A and R both are correct and R is not the correct explanation of A.

  3. A is correct and R is incorrect.

  4. A is incorrect and R is correct.

  5. A and R both are incorrect.


Correct Option: B
Explanation:

This option is correct because in capping, methyl guanosine triphosphate is added to the 5'-end of hnRNA. In tailing, adenylate residues are added at 3'-end in a template independent manner. It is the fully processed hnRNA, now called mRNA, that is transported out of the nucleus for translation.

The processes in which A. niger is used with solid substrate as Ipomoea batatas to produce citric acid is/are

  1. Koji process
  2. Submerged process
  3. Liquid surface culture process
  1. Only 1

  2. Only 2

  3. Only 3

  4. 1 and 2

  5. 2 and 3


Correct Option: A
Explanation:

In koji process, for the fermentation to produce citric acid, Aspergillus niger is used with solid substrate as Ipomoea batatas.

Match the column - I with column – II.

Column – I
Column – II
A. Polymerase chain reaction 1. Monoclonal antibody production
B. Tumour inducing plasmid 2. Breaking bond between insulin and galactosidase
C. Bromine cyanide 3. Introducing foreign genes into plants
D. Hybridoma technology 4. Gene amplification

  1. A - 1, B - 2, C - 3, D - 4

  2. A - 2, B - 1, C - 4, D - 3

  3. A - 3, B - 2, C - 1, D - 4

  4. A - 4, B - 3, C - 2, D - 1

  5. A - 1, B - 3, C - 4, D - 2


Correct Option: D
Explanation:

This option is correct because all are correctly matched. Polymerase chain reaction - Gene amplification Tumour inducing plasmid - Introducing foreign genes into plants Bromine cyanide - Breaking bond between insulin and galactosidase Hybridoma technology - Monoclonal antibody production

Match the column - I with column – II and select the correct option.

Column – I
Column – II
A. Glyoxylic acid reaction 1. Detection of aromatic amino acids
B. Edman degradation 2. Identification of 4-hydroxyphenylalanine
C. Millon's reagent 3. Determination of the amino acid sequence of a protein
D. Xanthoproteic reaction 4. Identification of tryptan
  1. A – 1, B – 2, C – 3, D – 4

  2. A – 1, B – 2, C – 4, D – 3

  3. A – 2, B – 3, C – 4, D – 1

  4. A – 4, B – 3, C – 2, D – 1

  5. A – 4, B – 3, C – 2, D – 1


Correct Option: D
Explanation:

Glyoxylic acid reaction is for identification of tryptan. Edman degradation can be used to determine the amino acid sequence of a protein. Millon's reagent is for identification of 4-hydroxyphenylalanine. Aromatic amino acids can be detected by Xanthoproteic reaction.

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