Venice was a major center of trade and commerce during the Middle Ages due to its strategic location on the Adriatic Sea and its control of trade routes to the East.

The Silk Road was a network of trade routes that connected Europe with Asia during the Middle Ages. It was named after the silk that was traded along the route.

Xi'an, formerly known as Chang'an, was the eastern terminus of the Silk Road during the Middle Ages.

The Spice Route was a trade route that connected Europe with the Middle East during the Middle Ages. It was named after the spices that were traded along the route.

Cairo was the eastern terminus of the Spice Route during the Middle Ages.

The Gold Road was a trade route that connected Europe with Africa during the Middle Ages. It was named after the gold that was traded along the route.

Timbuktu was the western terminus of the Gold Road during the Middle Ages.

The Amber Road was a trade route that connected Europe with Russia during the Middle Ages. It was named after the amber that was traded along the route.

Novgorod was the eastern terminus of the Amber Road during the Middle Ages.

The Purple Road was a trade route that connected Europe with the Byzantine Empire during the Middle Ages. It was named after the purple dye that was traded along the route.

Constantinople was the eastern terminus of the Purple Road during the Middle Ages.

The Pilgrim's Road was a trade route that connected Europe with the Holy Land during the Middle Ages. It was named after the pilgrims who traveled along the route.

Jerusalem was the eastern terminus of the Pilgrim's Road during the Middle Ages.

The Spice Route was a trade route that connected Europe with India during the Middle Ages. It was named after the spices that were traded along the route.

Calicut was the eastern terminus of the Spice Route during the Middle Ages.