The Lakota, also known as the Teton Sioux, were a powerful and influential tribe that dominated the northern Great Plains, including parts of the Missouri River Valley.

The Lewis and Clark Expedition was commissioned by President Thomas Jefferson to explore the vast Louisiana Purchase, acquired from France in 1803, and to establish trade relations with Native American tribes.

Chimney Rock, a prominent rock formation in Nebraska, was named by William Clark after his friend and fellow explorer, John Colter, who had previously visited the area.

The steamboat Yellowstone, captained by William Clark, successfully navigated the Missouri River as far as Fort Union in present-day Montana, demonstrating the potential for steam-powered transportation on the river.

The Homestead Act of 1862 encouraged settlement in the western United States, including the Missouri River Valley, by granting public land to individuals who agreed to cultivate it.

Jesse James and his gang of outlaws carried out a series of robberies and train heists in the Missouri River Valley, becoming notorious figures in American history.

St. Louis, Missouri, was a bustling hub for trade, transportation, and exploration, serving as a starting point for many expeditions into the American West.

The Missouri River Flood of 1993 was a major natural disaster that affected several states along the Missouri River, resulting in significant flooding and infrastructure damage.

The Mandan tribe, known for their earth lodge villages and rich cultural practices, played a vital role in preserving their heritage and traditions in the Missouri River Valley.

The Fort Peck Dam, located on the Missouri River in Montana, was built as part of the Pick-Sloan Missouri Basin Program to control flooding and generate hydroelectric power.

Theodore Roosevelt National Park, located in North Dakota, is known for its scenic badlands, diverse wildlife, and historical significance associated with President Theodore Roosevelt.

Black Elk, a Lakota spiritual leader and medicine man, promoted peace and unity among Native American tribes in the Missouri River Valley and beyond.

The Missouri River joins the Mississippi River near St. Louis, forming the longest river system in North America.

Fort Lisa, located in present-day Nebraska, was established by Manuel Lisa, a fur trader, to protect fur traders and maintain peace among Native American tribes in the Missouri River Valley.

The Pawnee tribe, known for their impressive earth lodge villages and agricultural skills, were prominent inhabitants of the Missouri River Valley.