The primary responsibility of a guardian in the context of research is to protect the rights and interests of the individual under guardianship. This includes ensuring that the individual is not exploited, that their rights are respected, and that they are not subjected to any harm or undue risk.

Informed consent is required in research involving individuals under guardianship when the individual is capable of providing consent. This means that the individual must be able to understand the nature and purpose of the research, the potential risks and benefits, and the alternatives to participation. If the individual is incapable of providing consent, a guardian may provide consent on their behalf.

All of the above ethical considerations should be taken into account when conducting research involving individuals under guardianship. It is important to minimize the potential for exploitation and coercion, protect the privacy and confidentiality of the individual, obtain informed consent, and ensure that the research is conducted in a manner that is respectful of the individual's dignity and autonomy.

All of the above legal requirements must be met when conducting research involving individuals under guardianship. It is important to obtain informed consent from the individual under guardianship or their guardian, ensure that the research is conducted in a manner that is consistent with applicable laws and regulations, and protect the privacy and confidentiality of the individual.

All of the above challenges may be faced by researchers when conducting research involving individuals under guardianship. It is important to be aware of these challenges and to take steps to address them.