Washington, D.C. is known as the "Holy City" of the United States and is home to the Basilica of the National Shrine of the Immaculate Conception, the largest Catholic church in North America.

The Basilica of Our Lady of Guadalupe is a famous pilgrimage site in Mexico City, where the Virgin of Guadalupe is said to have appeared to Juan Diego in 1531. It is one of the most visited Catholic pilgrimage sites in the world.

Quebec City is known for its annual pilgrimage to the Shrine of Sainte-Anne-de-Beaupré, dedicated to Saint Anne, the mother of Mary. The shrine is a popular pilgrimage destination for Catholics from around the world.

The National Shrine of Saint Katharine Drexel is a pilgrimage site in Bensalem, Pennsylvania, where the body of Saint Katharine Drexel is enshrined. She was a Catholic nun and missionary who founded the Sisters of the Blessed Sacrament for Indians and Colored People.

Philadelphia is home to the Shrine of the Miraculous Medal, a pilgrimage site dedicated to the Virgin Mary. The shrine was built in 1878 and is a popular destination for pilgrims from around the world.

The Oratory of Saint Joseph is a pilgrimage site in Montreal, Canada, where the body of Saint André Bessette is enshrined. He was a Canadian religious brother of the Congregation of Holy Cross and is known for his healing miracles.

The Shrine of Saint Elizabeth Ann Seton is located in Emmitsburg, Maryland, where she founded the Sisters of Charity of St. Joseph. She was the first American-born saint and is known for her work with the poor and sick.

The body of Saint Juan Diego is enshrined in the Basilica of Our Lady of Guadalupe in Mexico City. He was a Mexican peasant who is said to have witnessed the apparition of the Virgin of Guadalupe in 1531.

The Shrine of the Little Flower is located in Royal Oak, Michigan, and is dedicated to Saint Thérèse of Lisieux. She was a French Carmelite nun and is known for her "little way" of spiritual perfection.

The body of Saint Marguerite d'Youville is enshrined in the Notre-Dame Basilica in Montreal, Canada. She was a French-Canadian religious sister and is known for her work with the poor and sick.

The Shrine of Saint Jude is located in Chicago, Illinois, and is dedicated to Saint Jude, the patron saint of lost causes. It is a popular pilgrimage destination for people seeking help with difficult situations.

The body of Saint Miguel Hidalgo y Costilla is enshrined in the Colegiata de Nuestra Señora de Guadalupe in Dolores Hidalgo, Guanajuato, Mexico. He was a Mexican priest and revolutionary leader who is known as the "Father of Mexican Independence.

The Shrine of Saint Anthony of Padua is located in Boston, Massachusetts, and is dedicated to Saint Anthony of Padua, a popular saint known for his help with financial difficulties. It is a popular pilgrimage destination for people seeking financial assistance.

The body of Saint François de Laval is enshrined in the Notre-Dame Basilica in Quebec City, Canada. He was the first Roman Catholic bishop of Quebec and is known as the "Father of the Canadian Church.

The Shrine of Saint Patrick is located in New York City and is dedicated to Saint Patrick, the patron saint of Ireland. It is a popular pilgrimage destination for people seeking help with finding a spouse.