Neural Basis of Cognitive Disorders

Description: This quiz will test your knowledge on the neural basis of cognitive disorders.
Number of Questions: 15
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Tags: cognitive disorders neuropsychology neuroscience
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Which of the following is not a type of cognitive disorder?

  1. Alzheimer's disease

  2. Parkinson's disease

  3. Schizophrenia

  4. Attention deficit hyperactivity disorder (ADHD)


Correct Option:
Explanation:

ADHD is a neurodevelopmental disorder, not a cognitive disorder.

What is the most common type of cognitive disorder?

  1. Alzheimer's disease

  2. Parkinson's disease

  3. Schizophrenia

  4. Huntington's disease


Correct Option: A
Explanation:

Alzheimer's disease is the most common type of cognitive disorder, accounting for 60-80% of cases.

What is the primary cause of Alzheimer's disease?

  1. Amyloid plaques

  2. Tau tangles

  3. Neuroinflammation

  4. Oxidative stress


Correct Option:
Explanation:

Alzheimer's disease is characterized by the accumulation of amyloid plaques and tau tangles in the brain.

Which brain region is most affected in Parkinson's disease?

  1. Substantia nigra

  2. Basal ganglia

  3. Cerebellum

  4. Frontal cortex


Correct Option: A
Explanation:

Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra.

What is the primary symptom of schizophrenia?

  1. Hallucinations

  2. Delusions

  3. Disorganized speech

  4. Negative symptoms


Correct Option: A
Explanation:

Hallucinations are the most common symptom of schizophrenia.

Which neurotransmitter is implicated in the pathophysiology of schizophrenia?

  1. Dopamine

  2. Serotonin

  3. Glutamate

  4. GABA


Correct Option: A
Explanation:

Dopamine is implicated in the pathophysiology of schizophrenia, with hyperactivity of the mesolimbic dopamine pathway thought to contribute to positive symptoms.

What is the primary cause of Huntington's disease?

  1. CAG trinucleotide repeat expansion in the HTT gene

  2. Mutation in the PRNP gene

  3. Deletion in the FMR1 gene

  4. Duplication in the MECP2 gene


Correct Option: A
Explanation:

Huntington's disease is caused by a CAG trinucleotide repeat expansion in the HTT gene.

Which brain region is most affected in Huntington's disease?

  1. Striatum

  2. Cerebellum

  3. Frontal cortex

  4. Hippocampus


Correct Option: A
Explanation:

Huntington's disease is characterized by the degeneration of neurons in the striatum.

What is the primary symptom of frontotemporal dementia?

  1. Memory loss

  2. Language impairment

  3. Behavioral changes

  4. Motor dysfunction


Correct Option: C
Explanation:

Behavioral changes, such as disinhibition and apathy, are the primary symptoms of frontotemporal dementia.

Which brain region is most affected in frontotemporal dementia?

  1. Frontal cortex

  2. Temporal cortex

  3. Parietal cortex

  4. Occipital cortex


Correct Option: A
Explanation:

Frontotemporal dementia is characterized by the degeneration of neurons in the frontal cortex.

What is the primary cause of Creutzfeldt-Jakob disease?

  1. Prion protein misfolding

  2. Amyloid plaque accumulation

  3. Tau tangle formation

  4. Neuroinflammation


Correct Option: A
Explanation:

Creutzfeldt-Jakob disease is caused by the misfolding of the prion protein.

Which brain region is most affected in Creutzfeldt-Jakob disease?

  1. Cerebral cortex

  2. Basal ganglia

  3. Cerebellum

  4. Brainstem


Correct Option: A
Explanation:

Creutzfeldt-Jakob disease is characterized by the degeneration of neurons in the cerebral cortex.

What is the primary symptom of multiple sclerosis?

  1. Muscle weakness

  2. Sensory disturbances

  3. Fatigue

  4. Cognitive impairment


Correct Option: A
Explanation:

Muscle weakness is the primary symptom of multiple sclerosis.

Which brain region is most affected in multiple sclerosis?

  1. White matter

  2. Gray matter

  3. Cerebellum

  4. Brainstem


Correct Option: A
Explanation:

Multiple sclerosis is characterized by the demyelination of neurons in the white matter.

What is the primary cause of amyotrophic lateral sclerosis (ALS)?

  1. Motor neuron degeneration

  2. Muscle atrophy

  3. Neuroinflammation

  4. Oxidative stress


Correct Option: A
Explanation:

ALS is caused by the degeneration of motor neurons in the brain and spinal cord.

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