Eastern European teams have often faced challenges in the UEFA Champions League, with a lack of financial resources and infrastructure hindering their competitiveness.

The NFC East division has experienced a prolonged drought in Super Bowl victories, with no team from the division winning the championship since the 1990s.

The Eastern Conference in the NBA has historically been perceived as weaker compared to the Western Conference, with fewer teams reaching the NBA Finals and winning championships.

The NL Central division in Major League Baseball has struggled to produce World Series contenders, with no team from the division winning the championship since the early 2000s.

The Eastern Conference in the NHL has historically been perceived as weaker compared to the Western Conference, with fewer teams reaching the Stanley Cup Finals and winning championships.

The Americas region in international cricket has historically struggled to compete with the top teams from Asia, Europe, and Oceania, often failing to qualify for major tournaments.

The Americas region in the Rugby World Cup has struggled to compete with the top teams from Europe and the Southern Hemisphere, often failing to reach the knockout stages of the tournament.

North America has historically struggled to produce competitive teams and drivers in the Formula One World Championship, with few drivers achieving significant success.

Asia has historically struggled to produce competitive cyclists in the Tour de France, with few riders achieving significant success or winning stages.

Asia has historically struggled to compete with the top athletes from Europe, Africa, and the Americas in the World Athletics Championships, often failing to win medals in major events.

Asia has historically struggled to compete with the top athletes from Europe, Africa, and Oceania in the Commonwealth Games, often failing to win medals across multiple sports.

The Caribbean region has historically struggled to compete with the top athletes from North America and South America in the Pan American Games, often failing to win medals in major sports.

Central Asia has historically struggled to compete with the top athletes from East Asia and Southeast Asia in the Asian Games, often failing to win medals across multiple sports.

Southern Africa has historically struggled to compete with the top athletes from North Africa and West Africa in the African Games, often failing to win medals in major sports.

Micronesia has historically struggled to compete with the top athletes from Melanesia and Polynesia in the Pacific Games, often failing to win medals across multiple sports.