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Biotechnology in Therapeutics

Description: This quiz covers the fundamentals of Biotechnology in Therapeutics, including gene therapy, monoclonal antibodies, and stem cell therapy.
Number of Questions: 15
Created by:
Tags: biotechnology therapeutics gene therapy monoclonal antibodies stem cell therapy
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Which of the following is NOT a type of gene therapy?

  1. Gene augmentation

  2. Gene silencing

  3. Gene editing

  4. Gene replacement


Correct Option: A
Explanation:

Gene augmentation involves introducing a functional gene into a cell to compensate for a defective gene, while gene silencing, gene editing, and gene replacement all involve modifying or replacing a defective gene.

What is the primary mechanism of action of monoclonal antibodies in therapeutics?

  1. Binding to specific antigens and neutralizing their activity

  2. Stimulating the immune system to attack cancer cells

  3. Delivering cytotoxic agents directly to cancer cells

  4. Inhibiting the growth of blood vessels that supply tumors


Correct Option: A
Explanation:

Monoclonal antibodies are designed to bind to specific antigens, such as those found on the surface of cancer cells or viruses, and neutralize their activity by preventing them from interacting with their targets.

Which type of stem cell is capable of differentiating into all cell types in the body?

  1. Embryonic stem cells

  2. Adult stem cells

  3. Induced pluripotent stem cells

  4. Mesenchymal stem cells


Correct Option: A
Explanation:

Embryonic stem cells are pluripotent, meaning they have the potential to differentiate into all cell types in the body, including those found in the three germ layers: ectoderm, mesoderm, and endoderm.

What is the main advantage of using stem cells in regenerative medicine?

  1. Their ability to self-renew and proliferate indefinitely

  2. Their ability to differentiate into multiple cell types

  3. Their ability to migrate to damaged tissues and repair them

  4. Their ability to suppress the immune system and prevent rejection


Correct Option: B
Explanation:

The main advantage of using stem cells in regenerative medicine is their ability to differentiate into multiple cell types, which allows them to replace damaged or diseased cells and restore tissue function.

Which of the following is NOT a potential application of gene therapy?

  1. Treating genetic disorders

  2. Developing new vaccines

  3. Curing cancer

  4. Enhancing athletic performance


Correct Option: D
Explanation:

Gene therapy is primarily used for treating genetic disorders, developing new vaccines, and curing cancer. Enhancing athletic performance is not a legitimate application of gene therapy.

What is the main challenge associated with using monoclonal antibodies in cancer therapy?

  1. They can be expensive to produce

  2. They can cause severe side effects

  3. They can lead to the development of drug resistance

  4. They can be difficult to administer to patients


Correct Option: C
Explanation:

One of the main challenges associated with using monoclonal antibodies in cancer therapy is that cancer cells can develop resistance to the treatment over time, rendering the antibodies less effective.

Which of the following is NOT a potential application of stem cell therapy?

  1. Treating spinal cord injuries

  2. Regenerating damaged heart tissue

  3. Curing type 1 diabetes

  4. Enhancing memory and cognitive function


Correct Option: D
Explanation:

While stem cell therapy has shown promise in treating spinal cord injuries, regenerating damaged heart tissue, and curing type 1 diabetes, there is no evidence to support its use in enhancing memory and cognitive function.

Which type of gene therapy involves replacing a defective gene with a functional copy?

  1. Gene augmentation

  2. Gene silencing

  3. Gene editing

  4. Gene replacement


Correct Option: D
Explanation:

Gene replacement therapy involves replacing a defective gene with a functional copy, either by directly inserting the functional gene into the genome or by using a viral vector to deliver the gene to the target cells.

What is the primary mechanism of action of CAR T-cell therapy in cancer treatment?

  1. Binding to specific antigens on cancer cells and activating the immune system to attack them

  2. Delivering cytotoxic agents directly to cancer cells

  3. Inhibiting the growth of blood vessels that supply tumors

  4. Stimulating the production of antibodies against cancer cells


Correct Option: A
Explanation:

CAR T-cell therapy involves genetically modifying T cells to express chimeric antigen receptors (CARs), which enable the T cells to recognize and bind to specific antigens on cancer cells. This binding activates the T cells, causing them to attack and destroy the cancer cells.

Which type of stem cell is commonly used in bone marrow transplants?

  1. Embryonic stem cells

  2. Adult stem cells

  3. Induced pluripotent stem cells

  4. Mesenchymal stem cells


Correct Option: B
Explanation:

Adult stem cells, specifically hematopoietic stem cells, are commonly used in bone marrow transplants to replenish the patient's blood-forming cells.

What is the main advantage of using monoclonal antibodies over traditional chemotherapy in cancer treatment?

  1. They are more effective in killing cancer cells

  2. They have fewer side effects

  3. They can target specific cancer cells more precisely

  4. They are less expensive to produce


Correct Option: C
Explanation:

Monoclonal antibodies can be designed to target specific antigens on cancer cells, allowing them to selectively kill cancer cells while sparing healthy cells. This makes them more precise and less toxic than traditional chemotherapy drugs.

Which type of gene therapy involves using a viral vector to deliver a functional gene to target cells?

  1. Gene augmentation

  2. Gene silencing

  3. Gene editing

  4. Viral vector-mediated gene transfer


Correct Option: D
Explanation:

Viral vector-mediated gene transfer involves using a modified virus to deliver a functional gene to target cells. The virus is engineered to be non-replicative and to carry the therapeutic gene, which is then integrated into the host cell's genome.

What is the main challenge associated with using stem cells in regenerative medicine?

  1. They can be difficult to obtain

  2. They can be difficult to differentiate into the desired cell types

  3. They can be rejected by the patient's immune system

  4. They can be prone to forming tumors


Correct Option: C
Explanation:

One of the main challenges associated with using stem cells in regenerative medicine is the risk of immune rejection. Stem cells from a donor may be recognized as foreign by the patient's immune system, leading to rejection of the transplanted cells.

Which type of stem cell is commonly used in cord blood transplants?

  1. Embryonic stem cells

  2. Adult stem cells

  3. Induced pluripotent stem cells

  4. Hematopoietic stem cells


Correct Option: D
Explanation:

Hematopoietic stem cells, which are found in cord blood, are commonly used in cord blood transplants to replenish the patient's blood-forming cells.

What is the main advantage of using gene therapy over traditional drug therapy?

  1. It can target the underlying genetic cause of a disease

  2. It has fewer side effects

  3. It is more effective in treating chronic diseases

  4. It is less expensive to administer


Correct Option: A
Explanation:

Gene therapy has the potential to target the underlying genetic cause of a disease, offering the possibility of a permanent cure. Traditional drug therapy often only treats the symptoms of a disease, not the underlying cause.

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