The first Spanish expedition to the Nueces River Valley was led by Cabeza de Vaca in 1528.

Alonso de Leon was the first European to settle in the Nueces River Valley in 1689.

Mission San Francisco de la Espada was the first Spanish mission in the Nueces River Valley, founded in 1731.

The main purpose of the Spanish missions in the Nueces River Valley was to convert the Native Americans to Christianity.

Goliad was the first Anglo-American settlement in the Nueces River Valley, founded in 1829.

James Power was the first Anglo-American to settle in the Nueces River Valley in 1824.

The Battle of Refugio took place in the Nueces River Valley during the Texas Revolution in 1836.

Jose Urrea was the Mexican general who led the Mexican army at the Battle of Refugio.

James Fannin was the Texan commander at the Battle of Refugio.

The Texans were forced to retreat after the Mexican army launched a surprise attack.

Goliad County was created in the Nueces River Valley in 1837.

Victoria was founded in the Nueces River Valley in 1840.

The Southern Pacific Railroad was built through the Nueces River Valley in the 1870s.

Agriculture was the main industry in the Nueces River Valley in the late 19th and early 20th centuries.

Corpus Christi is the largest city in the Nueces River Valley today.