William Morton is widely recognized as the father of modern anesthesia for his public demonstration of the use of ether as an anesthetic in 1846.

Ether was the first substance used as an anesthetic in surgery, demonstrated by William Morton in 1846.

The first successful use of anesthesia in dentistry was in 1844 by Horace Wells, who used nitrous oxide to extract a tooth painlessly.

Chloroform was widely used as an anesthetic during the American Civil War due to its rapid onset and shorter recovery time compared to ether.

August Bier introduced the concept of regional anesthesia in 1898, using cocaine to block nerve conduction in a specific region of the body.

Cocaine was the first anesthetic used for spinal anesthesia, introduced by August Bier in 1898.

The first successful use of general anesthesia with endotracheal intubation was in 1900 by Friedrich Trendelenburg.

Ether was the most commonly used anesthetic during World War I due to its familiarity and availability.

Ivan Magill developed the first cuffed endotracheal tube in 1928, which significantly improved airway management and reduced the risk of aspiration.

Curare was introduced as a muscle relaxant during anesthesia in the 1940s, allowing for better surgical conditions and reducing the need for deep anesthesia.

The first successful use of halothane as an anesthetic was in 1956, and it quickly became a popular choice due to its rapid onset, low toxicity, and minimal side effects.

Ketamine was widely used as an anesthetic during the Vietnam War due to its rapid onset, short duration of action, and ability to provide analgesia without causing respiratory depression.

Archie Brain developed the laryngeal mask airway (LMA) in 1981, providing an alternative to endotracheal intubation for airway management.

Propofol was introduced as a total intravenous anesthesia (TIVA) agent in the 1980s, offering rapid onset, short recovery time, and minimal side effects.